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Connection of Dried Blood Spot Proteomic Composition Dynamics and Heart Rate Variability in 3-day Female Dry Immersion

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Abstract

For the first time, the peculiarities of the blood proteomic composition depending on the predominance of the vegetative regulation type were analyzed under the conditions of dry immersion in women volunteers (age 30.17 ± 5.5 years, height 1.66 ± 0.1 m, weight 62.05 ± 8.4 kg, BMI 22.39 ± 2.2 kg/m2) with a natural menstrual cycle. The experiment “NAIAD-2020” was carried out at the Institute of Biomedical Problems (Moscow, Russia). It has been shown that under normal motor activity (in baseline studies), in individuals with various modulating types of autonomic influences, energy expenditure is provided mainly by carbohydrate metabolism, which has genetic features in the implementation of the pentose pathway. During dry immersion, with minimal motor activity, energy expenditure sharply decreases, leveling out vagus-mediated differences between the groups. On the second day of the recovery period, processes related to the functions of heat shock proteins and excosomes were noted.

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Data Availability

The datasets presented in this study can be found in online repositories. The names of the repository/repositories and accession number(s) can be found below: http://www.proteomexchange.org/, PXD027654.

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Acknowledgements

The authors of the manuscript are sincerely grateful to the team of Dry Immersion. Organizers – Department of Dr. E. Tomilovskaya, IBMP.

Funding

This work was carried out within the framework of the basic themes of the Russian Academy of Sciences 64.1 and 65.3 in 2021–22. The proteomic study was supported by the Megagrant of the Ministry of Science and Higher Education of the Russian Federation (Agreement with Skolkovo Institute of Science and Technology on December 11, 2019, no. 075–10-2019–083).

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Authors and Affiliations

  1. Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russian Federation

    L. H. Pastushkova, A. G. Goncharova, V. B. Rusanov, D. N. Kashirina, O. V. Popova, A. M. Nosovsky & I. M. Larina

  2. Skolkovo Institute of Science and Technology, Moscow, Russian Federation

    A. G. Brzhozovskiy, E. N. Nikolaev & A. S. Kononikhin

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  1. L. H. Pastushkova
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  2. A. G. Goncharova
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  3. V. B. Rusanov
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  4. D. N. Kashirina
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  5. A. G. Brzhozovskiy
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  6. O. V. Popova
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  7. A. M. Nosovsky
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  8. E. N. Nikolaev
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  9. A. S. Kononikhin
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  10. I. M. Larina
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Correspondence to O. V. Popova.

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Pastushkova, L.H., Goncharova, A.G., Rusanov, V.B. et al. Connection of Dried Blood Spot Proteomic Composition Dynamics and Heart Rate Variability in 3-day Female Dry Immersion. Microgravity Sci. Technol. 35, 19 (2023). https://doi.org/10.1007/s12217-023-10047-y

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