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Microwave-assisted green synthesis of silver nanoparticles using Annona squamosa peels extract: characterization, antioxidant, and amylase inhibition activities

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Abstract

In the current investigation, for the first time, silver nanoparticles (AgNPs) were synthesized using Annona squamosa peel extract as reducing and stabilizing agents via microwave irradiation assisted method. The nanoparticles had been characterized using UV–Vis, FTIR, XRD, and TEM techniques. The biosynthesized nanoparticles exhibited a broad peak at about 430 nm due to the surface plasmon resonance of the AgNPs. From the TEM images, the AgNPs are almost spherical, with an average size ranging from 18 to 35 nm. FT–IR analysis and phytochemical screening indicated that phenolic compounds and proteins of A. squamosa might have an essential role in AgNPs synthesis and stabilization. The antioxidant activity observed was almost comparable to the standard antioxidant agent (ascorbic acid). In vitro antidiabetic studies demonstrated the significant capability of AgNPs to inhibit the α-amylase in a dose-dependent manner. Thus, this green approach of AgNPs synthesis via microwave irradiated heating could be a quick, cost-effective, and environmentally friendly method, with the synthesized AgNPs proving to be a possible anti-diabetic therapeutic candidate.

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Authors and Affiliations

  1. Department of Biochemistry, Faculty of Agriculture, Fayoum University, Fayoum, Egypt

    Abdel-Moniem S. Hassan, AboBaker S. Mahmoud & Mostafa A. Eissa

  2. Deanship of Scientific Research, Umm Al-Qura University, Makkah, Saudi Arabia

    Mohamed Fawzy Ramadan

  3. Agricultural Biochemistry Department, Faculty of Agriculture, Zagazig University, Zagazig 44519, Egypt

    Mohamed Fawzy Ramadan

Authors
  1. Abdel-Moniem S. Hassan
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  2. AboBaker S. Mahmoud
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  3. Mohamed Fawzy Ramadan
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  4. Mostafa A. Eissa
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Correspondence to Mohamed Fawzy Ramadan.

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Hassan, AM.S., Mahmoud, A.S., Ramadan, M.F. et al. Microwave-assisted green synthesis of silver nanoparticles using Annona squamosa peels extract: characterization, antioxidant, and amylase inhibition activities. Rend. Fis. Acc. Lincei 33, 83–91 (2022). https://doi.org/10.1007/s12210-022-01049-w

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