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Evaluation of an extended viscoelastic model to predict hemolysis in cannulas and blood pumps

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Abstract

While the power-law model has been used widely to predict hemolysis numerically, it has a few inherent limitations that may result in inaccurate prediction. As an alternative, the viscoelastic model is a strain-based model derived using the mechanical properties of the red blood cell and erythrocyte. The model assumes two different time scales that lead to modified exponential trends versus the exposure time. As a zero-dimensional model, the viscoelastic model is not applicable to a complex multi-dimensional problem. In the present study, it is extended to a form based on partial differential equations for multi-dimensional hemodynamic flows such as cannulas and blood pumps. The extended method is revised further to comply with a physical constraint. When evaluated using experimental data and relative hemolysis indices, the extended viscoelastic model does not show a clear advantage over the power-law model for cannula problems with relatively short residence times. In contrast, the viscoelastic model shows improved agreement with experimental data consistently for flows inside blood pumps with relatively long residence times. Considering that the viscoelastic model was targeted originally at improving prediction at a long residence time, the present results are consistent with a previous study. As a result, it is implied that the extended viscoelastic model is useful for specific applications such as blood pumps compared to the previous methods.

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Authors and Affiliations

  1. Department of Mechanical Engineering, Sogang University, Seoul, Korea

    Seunghun Lee, Youngmoon Cho, Seongwon Kang, Nahmkeon Hur & Wonjung Kim

Authors
  1. Seunghun Lee
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  2. Youngmoon Cho
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  3. Seongwon Kang
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  4. Nahmkeon Hur
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  5. Wonjung Kim
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Corresponding author

Correspondence to Seongwon Kang.

Additional information

Recommended by Associate Editor Hyoung-gwon Choi

Seung Hun Lee received the B.S. and M.S. degrees in Mechanical Engineering from Sogang University, Korea in 2016 and 2018. His research interests include problems of mass transfer in medical devices.

Youngmoon Cho received the B.S. degree in Mechanical Engineering from Sogang University, Korea in 2015.

Seongwon Kang received the B.S. and M.S. degrees in Mechanical Engineering from Seoul National University, Korea in 1997 and 1999, and Ph.D. degree in Mechanical Engineering from Stanford University, USA in 2008.

Nahmkeon Hur received the B.S. and M.S. degrees in Mechanical Engineering from Seoul National University, Korea in 1979 and 1981, and Ph.D. degree in Mechanical Engineering from Stevens Institute of Technology, USA in 1988.

Wonjung Kim received the B.S. and M.S. degrees in Mechanical Engineering from Seoul National University, Korea in 2006 and 2009, and Ph.D. degree in Mechanical Engineering from Massachusetts Institute of Technology, USA in 2013.

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Lee, S., Cho, Y., Kang, S. et al. Evaluation of an extended viscoelastic model to predict hemolysis in cannulas and blood pumps. J Mech Sci Technol 33, 2181–2188 (2019). https://doi.org/10.1007/s12206-019-0420-0

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  • DOI: https://doi.org/10.1007/s12206-019-0420-0

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