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Patient-specific simulation for selective liver tumor treatment with noninvasive radiofrequency hyperthermia

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Abstract

In the present study, noninvasive selective heating of tumors, while sparing the normal cells, was investigated with a single electrode conductive hyperthermia technique using numerical simulations. A realistic patient-specific human anatomy, which was reconstructed and segmented from computed tomography images, was used to determine the thermal distribution in liver tumors during Radiofrequency (RF) heating. An RF electrode at 13.56 MHz was used as the heat source, and numerical simulations were performed with the aid of the multiphysics simulation platform Sim4Life. The experiments were conducted on a tissue-tumor agar phantom to validate the temperature increase pattern for different sizes of electrode and power modulation. A high temperature increase was achieved in the liver tumor from the patient-specific simulation, which elucidated that there was high-energy absorption of malignant tissues as compared to the normal surrounding tissues. The study also exhibits the effects of electrodes of different sizes and power modulations, which allows for an effective treatment planning, and the calculated thermal dose values depict no normal tissue damage, which gives more promising outcomes for clinical applications.

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Authors and Affiliations

  1. Department of Mechanical Engineering, Graduate School, Kookmin University, Seoul, 02707, Korea

    Bibin Prasad

  2. Union Medical Co., Uijeongbu-si, Gyeonggi-do, 480761, Korea

    You Ho Ha & Seung Ku Lee

  3. School of Mechanical Systems Engineering and Department of Integrative Biomedical Science and Engineering, Graduate School, Kookmin University, Seoul, 02707, Korea

    Jung Kyung Kim

Authors
  1. Bibin Prasad
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  2. You Ho Ha
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  3. Seung Ku Lee
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  4. Jung Kyung Kim
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Corresponding author

Correspondence to Jung Kyung Kim.

Additional information

Recommended by Associate Editor Sung Yang

Bibin Prasad received his B.E. degree in Mechanical Engineering from Anna University Chennai, India, in 2009. He then received his M.Tech. degree from TKM College of Engineering, University of Kerala, India in 2011. He is currently pursuing his Ph.D. degree in Mechanical Engineering at Kookmin University, Seoul, Republic of Korea. His areas of interest are heat transfer, computational fluid dynamics (CFD), thermal medicine, and cryogenic engineering.

Jung Kyung Kim received his B.Sc. degree in Mechanical Engineering in 1996 and then his M.Sc. and Ph.D. degrees both in Biomedical Engineering at Seoul National University in 1998 and 2003, respectively. From July 2004 to August 2006, he was a Postdoctoral Fellow in the Laboratory for Cell and Membrane Biophysics at the University of California, San Francisco, USA. After joining Kookmin University in Seoul, Republic of Korea on September 2006 as an Assistant Professor, he has been directing Biomedical Device Lab, and currently serves as an Associate Professor in School of Mechanical Systems Engineering.

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Prasad, B., Ha, Y.H., Lee, S.K. et al. Patient-specific simulation for selective liver tumor treatment with noninvasive radiofrequency hyperthermia. J Mech Sci Technol 30, 5837–5845 (2016). https://doi.org/10.1007/s12206-016-1154-x

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  • DOI: https://doi.org/10.1007/s12206-016-1154-x

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