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Comprehensive Contribution of Filament Thickness and Crosslinker Failure to the Rheological Property of F-actin Cytoskeleton

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Abstract

Rheological property of F-actin cytoskeleton is significant to the restructuring of cytoskeleton under a variety of cell activities. This study numerically validates the rheological property of F-actin cytoskeleton is not only a result of kinetic energy dissipation of F-actin, but also greatly depends on the configuration remodeling of networks structure. Both filament geometry and crosslinker properties can affect the remodeling of F-actin cytoskeleton. The crosslinker unbinding is found to dissipate energy and induce prominent stress relaxation in the F-actin adjacent to cross-linkages. Coupled with F-actin elasticity, the energy dissipation and stress relaxation are more significant in bundled F-actin networks than in single F-actin networks.

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Acknowledgment

The authors thank Dr. Oliver Lieleg and Prof. Xi-Qiao Feng for stimulating suggestions. This work is supported by ARC Future Fellowship Grant (FT100100172).

Conflict of interest

The authors, Tong Li, Ling Liu, Dean Hu, Adekunle Oloyede, Yin Xiao, Prasad Yarlagadda and YuanTong Gu, have no financial and personal relationships that could inappropriately influence or bias this work.

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No human/animal studies were carried out by the authors for this article.

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Authors and Affiliations

  1. School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, 4109, Australia

    Tong Li, Adekunle Oloyede, Prasad Yarlagadda & YuanTong Gu

  2. Department of Mechanical and Aerospace Engineering, Utah State University, Logan, UT, 84322, USA

    Ling Liu

  3. State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body, Hunan University, Changsha, 410082, China

    Dean Hu

  4. Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, 4109, Australia

    Yin Xiao

Authors
  1. Tong Li
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  2. Ling Liu
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  6. Prasad Yarlagadda
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Correspondence to YuanTong Gu.

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Associate Editor Chwee Teck Lim oversaw the review of this article.

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Li, T., Liu, L., Hu, D. et al. Comprehensive Contribution of Filament Thickness and Crosslinker Failure to the Rheological Property of F-actin Cytoskeleton. Cel. Mol. Bioeng. 8, 278–284 (2015). https://doi.org/10.1007/s12195-015-0382-y

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