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Effects of point spread function-based image reconstruction on neuroreceptor binding in positron emission tomography study with [11C]FLB 457

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Abstract

The ordered subset expectation maximization with a point spread function (OSEM-PSF) was developed to improve the spatial resolution of reconstructed positron emission tomography (PET) images and has been reported to improve the contrast of hot spots in PET studies for oncology. However, in neuroreceptor imaging, the regional radioactivity concentration changes dynamically during the scan, and the effects of the PSF may differ among various radioligands or quantification methods. In this study, we investigated the effects of the PSF on quantification in PET studies with [11C]FLB 457 of dopamine D2 receptors, using both phantom and human data acquired by the Siemens Biograph 16 imaging platform. In the phantom studies, we evaluated the hot contrast recovery coefficient (HCRC) for variously sized hot spheres and the linearity between the measured and true radioactivities in OSEM-PSF images. Next, in the human studies with [11C]FLB 457, radioactivity concentrations and binding potentials for the cerebral cortex and thalamus were compared between images reconstructed with and without PSF. In the phantom studies, the OSEM-PSF images showed a better HCRC compared to images without PSF, and they showed a good linear correlation with true radioactivity. In the human studies, the radioactivity concentration increased especially in small regions with high accumulation of [11C]FLB 457 when the PSF was included. However, little difference in the binding potentials was observed for the target regions between both types of reconstructed images. In conclusion, PSF-based reconstruction reduced the spill-over phenomena in small hot regions; however, it caused no increase in the binding potentials in the [11C]FLB 457 studies.

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Acknowledgments

We thank the staff of the clinical research support section, the clinical neuroimaging team, and the radiopharmaceutical production team at the Molecular Imaging Center, National Institute of Radiological Sciences, for their assistance in conducting the PET studies. This study was supported by the National Institute of Radiological Sciences in Japan as an IAEA Collaborating Center.

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Authors and Affiliations

  1. Biophysics Program, Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan

    Thonnapong Thongpraparn, Yoko Ikoma, Taiga Yamaya & Hiroshi Ito

  2. Division of Nuclear Medicine, Department of Radiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, 2 Prannok Rd., Bangkok-noi, Bangkok, 10700, Thailand

    Thonnapong Thongpraparn

  3. Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan

    Takahiro Shiraishi

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  1. Thonnapong Thongpraparn
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  2. Yoko Ikoma
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  4. Taiga Yamaya
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  5. Hiroshi Ito
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Correspondence to Yoko Ikoma.

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Thongpraparn, T., Ikoma, Y., Shiraishi, T. et al. Effects of point spread function-based image reconstruction on neuroreceptor binding in positron emission tomography study with [11C]FLB 457. Radiol Phys Technol 9, 127–137 (2016). https://doi.org/10.1007/s12194-015-0343-0

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  • DOI: https://doi.org/10.1007/s12194-015-0343-0

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