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Risk factors associated with infection-related mortality of Bacillus cereus bacteremia in hematologic disorders

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Abstract

The mortality risk factors in B. cereus bacteremia in hematologic disorders are still unknown. In this study, patients with B. cereus bacteremia in hematologic disorders were selected in St. lukes international hospital and from electronic databases. A total of 176 patients [median age, 41 years (3–88 years); 99 (56%) males] were included. Of these patients, 141 (80%) had acute leukemia, and 93 (53%) died. Univariate analysis showed that neutropenia, CNS, gastrointestinal, and respiratory infections/symptoms were significantly associated with infection-related death. Meanwhile, glycopeptide use and management with source control were protective factors. Multivariate logistic regression analysis showed that infection-related death was significantly associated with CNS [odds ratio (OR): 3.49, 95% confidence interval (CI) 1.25–9.80], gastrointestinal (OR: 5.22, 95% CI 1.82–8.99), and respiratory infections/symptoms (OR: 8.98, 95% CI 1.62–49.9), as well as glycopeptide use (OR: 0.10, 95% CI 0.03–0.31) and source control (OR: 0.11, 95% CI 0.03–0.37). In conclusion, early glycopeptide administration and source control should be performed upon detection of infections suspicious for B. cereus.

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Funding

This study received no external funding.

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Authors and Affiliations

  1. Department of Infectious Diseases, St. Luke’s International Hospital, 9-1, Akashi-cho, Chuo-ku, Tokyo, Japan

    Tomohito Shimada, Kazuhiro Ishikawa & Nobuyoshi Mori

  2. Library, Department of Academic Resources, St. Luke’s International University, Tokyo, Japan

    Fujimi Kawai

  3. Center for Surveillance, Immunization, and Epidemiologic Research, National Institute of Infectious Diseases, Tokyo, Japan

    Daisuke Yoneoka

Authors
  1. Tomohito Shimada
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  2. Kazuhiro Ishikawa
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  3. Fujimi Kawai
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  4. Daisuke Yoneoka
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  5. Nobuyoshi Mori
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Contributions

TS collected the clinical data, reviewed the literature, and wrote the initial draft of the manuscript. DY provided his statistical expertise. KI and NM supervised and edited the manuscript. All authors agreed to the content of this manuscript and its submission this journal.

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Correspondence to Kazuhiro Ishikawa.

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Supplementary Information

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Additional file 1

: Search terms used to search three databases (PubMed, Embase, and Ichushi) for relevant cases. (DOCX 13 KB)

Additional file 2

: Table summarizing the clinical characteristics of cases of B. cereus bacteremia in hematologic disorders found in a literature review. (DOCX 103 KB)

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Shimada, T., Ishikawa, K., Kawai, F. et al. Risk factors associated with infection-related mortality of Bacillus cereus bacteremia in hematologic disorders. Int J Hematol 118, 726–730 (2023). https://doi.org/10.1007/s12185-023-03671-2

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  • DOI: https://doi.org/10.1007/s12185-023-03671-2

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