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Extracellular vesicle-mediated remodeling of the bone marrow microenvironment in myeloid malignancies

  • Progress in Hematology
  • Stem cell regulation and dynamics in myeloid malignancies
  • Published:
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Abstract

Hematopoiesis is maintained and regulated by a bone marrow-specific microenvironment called a niche. In hematological malignancies, tumor cells induce niche remodeling, and the reconstructed niche is closely linked to disease pathogenesis. Recent studies have suggested that extracellular vesicles (EVs) secreted from tumor cells play a principal role in niche remodeling in hematological malignancies. Although EVs are emerging as potential therapeutic targets, the underlying mechanism of action remains unclear, and selective inhibition remains a challenge. This review summarizes remodeling of the bone marrow microenvironment in hematological malignancies and its contribution to pathogenesis, as well as roles of tumor-derived EVs, and provides a perspective on future research in this field.

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Acknowledgements

This work was supported by AMED (22gm6210022h0003), JSPS KAKENHI (20H00537 (DI), 20K21622 (DI), 20J01911(YH), 21K16258(YH)), a grant from SENSHIN Medical Research Foundation (DI), TERUMO LIFE SCIENCE FOUNDATION (DI), Daiwa Securities Health Foundation (DI), The MEXT Joint Research Center program, Yokohama City University (DI), and Nippon Shinyaku (YH).

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  1. Department of Hematology-Oncology, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation at Kobe, 6-3-7, Minatojimaminami-machi, Chuo-ku, Kobe, 650-0047, Japan

    Yasutaka Hayashi, Koutarou Nishimura, Atsushi Tanaka & Daichi Inoue

  2. Laboratory of Immunology, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan

    Atsushi Tanaka

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Hayashi, Y., Nishimura, K., Tanaka, A. et al. Extracellular vesicle-mediated remodeling of the bone marrow microenvironment in myeloid malignancies. Int J Hematol 117, 821–829 (2023). https://doi.org/10.1007/s12185-023-03587-x

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