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Severe short-term adverse events in related bone marrow or peripheral blood stem cell donors

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Abstract

The incidence of severe adverse events (SAEs) and associated risk factors in hematopoietic cell transplantation donors needs to be clarified for related donors (relatives of the transplant recipient), whose criteria for donation are more lenient than for unrelated donors. Data from related donors registered in the Japanese national data registry database between 2005 and 2021 were evaluated to determine the association of short-term SAE incidence with donor characteristics at registration.

Fourteen of 4339 bone marrow (BM) donors (0.32%) and 54 of 10,684 peripheral blood stem cell (PBSC) donors (0.51%) experienced confirmed SAEs during the short donation period. No deaths were observed. Past medical history was a common risk factor for SAEs in both BM and PBSC donors. Age of 60 years or older and female sex were identified as risk factors for SAEs in PBSC donors. Female sex was also a risk factor for poor mobilization, which resulted in discontinuation of PBSC collection.

Although donors should be selected carefully, a certain level of safety is ensured for related donors in Japan. Donor safety should be further increased by improving the selection method for related donors and extending the follow-up period.

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Acknowledgements

The authors are grateful for the work of all the physicians and data managers who contributed valuable related donor data to the Related Hematopoietic Stem Cell Donor Registry Center.  

Funding

None to disclose.

Author information

Authors and Affiliations

  1. Division of Blood Transfusion, Shinshu University Hospital, 3-1-1, Asahi, Matsumoto, 390-8621, Japan

    Ryu Yanagisawa

  2. Department of Hematology, Nippon Medical School, Tokyo, Japan

    Tsuneaki Hirakawa

  3. Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan

    Noriko Doki

  4. Department of Hematology, Hyogo Medical University Hospital, Nishinomiya, Japan

    Kazuhiro Ikegame

  5. Department of Hematology and Oncology, Okayama University Hospital, Okayama, Japan

    Ken-ichi Matsuoka

  6. Department of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan

    Takahiro Fukuda

  7. Hematology, Osaka Metropolitan University, Osaka, Japan

    Hirohisa Nakamae & Masayuki Hino

  8. Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan

    Shuichi Ota

  9. Department of Hematology, Kobe City Medical Center General Hospital, Kobe, Japan

    Nobuhiro Hiramoto

  10. Department of Hematology, Osaka International Cancer Institute, Osaka, Japan

    Jun Ishikawa

  11. Department of Hematology, Hokkaido University Hospital, Sapporo, Japan

    Takahide Ara

  12. Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan

    Masatsugu Tanaka

  13. Department of Pediatrics, Kyushu University Hospital, Fukuoka, Japan

    Yuhki Koga

  14. Department of Hematology, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan

    Toshiro Kawakita

  15. Department of Hematology, University of Tsukuba Hospital, Tsukuba, Japan

    Yumiko Maruyama

  16. Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan

    Yoshinobu Kanda

  17. Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan

    Yoshiko Atsuta

  18. Department of Registry Science for Transplant and Cellular Therapy, Aichi Medical University School of Medicine, Nagakute, Japan

    Yoshiko Atsuta

  19. Department of Pediatrics, Tokai University School of Medicine, Isehara, Japan

    Hiromasa Yabe

  20. Department of Hematology, Japanese Red Cross Medical Center, Tokyo, Japan

    Nobuhiro Tsukada

Authors
  1. Ryu Yanagisawa
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  2. Tsuneaki Hirakawa
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  3. Noriko Doki
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  4. Kazuhiro Ikegame
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  5. Ken-ichi Matsuoka
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  6. Takahiro Fukuda
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  7. Hirohisa Nakamae
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  8. Shuichi Ota
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  9. Nobuhiro Hiramoto
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  10. Jun Ishikawa
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  11. Takahide Ara
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  12. Masatsugu Tanaka
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  13. Yuhki Koga
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  14. Toshiro Kawakita
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  15. Yumiko Maruyama
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  16. Yoshinobu Kanda
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  17. Masayuki Hino
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  18. Yoshiko Atsuta
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  19. Hiromasa Yabe
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  20. Nobuhiro Tsukada
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Contributions

RY designed the study, analyzed data, and wrote the manuscript. TH, HY, and NT designed the study, advised on methods, and wrote the manuscript. ND, KI, KM, TF, HN, SO, NH, JI, TA, MT, YK, TK, YM, and YK collected data and revised the manuscript. MH, and HY collected data, revised the manuscript, and were responsible for data management at JDCHCT. YA managed the unified registry database and revised the manuscript. All authors approved the final version of the manuscript.

Corresponding author

Correspondence to Ryu Yanagisawa.

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Conflict of interest

M.H. received research grants and lecture fees from Kyowa Kirin Co. Ltd. and Chugai Pharma Co. Ltd. The other authors declare that they have no conflicts of interest to disclose.

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Yanagisawa, R., Hirakawa, T., Doki, N. et al. Severe short-term adverse events in related bone marrow or peripheral blood stem cell donors. Int J Hematol 117, 421–427 (2023). https://doi.org/10.1007/s12185-022-03489-4

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  • DOI: https://doi.org/10.1007/s12185-022-03489-4

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