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Guidelines for the treatment of chronic myeloid leukemia from the NCCN and ELN: differences and similarities

  • Progress in Hematology
  • Chronic myeloid leukemia: the cutting-edge evidence and things we should know
  • Published:
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Abstract

Patients diagnosed with chronic myeloid leukemia (CML) in chronic phase can now have a life expectancy comparable to that of the general population thanks to the use of tyrosine kinase inhibitor (TKI) therapies. Although most patients with CML require lifelong TKI therapy, it is possible for some patients to achieve treatment-free remission. These spectacular results have been made possible by the development of superior treatment modalities as well as clinicians' efforts in strictly adhering to clinical guidelines such as the National Comprehensive Cancer Network (NCCN) and European Leukemia Network (ELN). CML treatment recommendations reported in these guidelines are the result of years of selecting and incorporating the most reliable evidence. In this review, we provide a synopsis of the differences and similarities that exist between the NCCN and ELN guidelines.

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Authors and Affiliations

  1. Department of Hematology, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey

    Zehra Narlı Özdemir

  2. Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa, Istanbul, Turkey

    Necati Alp Kılıçaslan

  3. Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Musa Yılmaz

  4. Division of Hematology, Department of Internal Medicine, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa, Fatih, Istanbul, Turkey

    Ahmet Emre Eşkazan

Authors
  1. Zehra Narlı Özdemir
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  2. Necati Alp Kılıçaslan
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  3. Musa Yılmaz
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  4. Ahmet Emre Eşkazan
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Correspondence to Ahmet Emre Eşkazan.

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AEE has received advisory board and speaker bureau honoraria from Novartis, Bristol-Myers Squibb, and Pfizer. MY has received research funds from Daiichi Sankyo and Pfizer. All other authors have no conflict of interest to declare.

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Narlı Özdemir, Z., Kılıçaslan, N.A., Yılmaz, M. et al. Guidelines for the treatment of chronic myeloid leukemia from the NCCN and ELN: differences and similarities. Int J Hematol 117, 3–15 (2023). https://doi.org/10.1007/s12185-022-03446-1

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  • DOI: https://doi.org/10.1007/s12185-022-03446-1

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