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Comparison between filgrastim biosimilar and filgrastim original for the management of neutropenia after salvage chemotherapy for malignant lymphoma

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Abstract

In this study, the efficacy and safety of filgrastim biosimilar (F-BS) were retrospectively compared to those of filgrastim original in the treatment of malignant lymphoma with CHASE (± R) or DeVIC(± R) in 78 patients. The median number of filgrastim doses was 11 in the F-BS group and 8 in the filgrastim group after CHASE (± R) (p = 0.8), and 10 in the F-BS group and 10 in the filgrastim group after DeVIC (± R) (p = 0.45). The median days until neutrophil recovery to ≥ 1000/μL was 10 days with F-BS versus 10 days with filgrastim after CHASE ± R (p = 0.59), and 9 days with F-BS versus 10 days with filgrastim after DeVIC ± R (p = 0.828). Febrile neutropenia (FN) was observed in 5 patients (41.7%) in the F-BS group and 9 (52.9%) in the filgrastim group after CHASE ± R therapy (p = 0.616), and in 11 patients (36.7%) in the F-BS group and 9 (47.4%) in the filgrastim group after DeVIC ± R (p = 0.462). The present results suggest that the efficacy and safety of F-BS are comparable to those of filgrastim original, with no significant differences in clinical factors. Use of F-BS also reduced medical costs per course of CHASE ± R therapy by 170.22 US dollars.

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Acknowledgements

The authors would like to thank all of the physicians, nurses, pharmacists, and support personnel for their care of patients in this study.

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Authors and Affiliations

  1. Department of Pharmacology, Toranomon Hospital, Tokyo, Japan

    Rena Shimano, Izumi Nasu, Yuichiro Kashiwamura, Masahiro Hayashi & Tadaaki Ito

  2. Department of Hematology, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo, 105-8470, Japan

    Hisashi Yamamoto, Go Yamamoto, Naoyuki Uchida & Shuichi Taniguchi

  3. Okinaka Memorial Institute for Medical Research, Tokyo, Japan

    Hisashi Yamamoto, Go Yamamoto, Naoyuki Uchida, Shuichi Taniguchi & Tadaaki Ito

Authors
  1. Rena Shimano
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  2. Hisashi Yamamoto
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  3. Izumi Nasu
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  4. Yuichiro Kashiwamura
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  5. Go Yamamoto
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  6. Naoyuki Uchida
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  7. Shuichi Taniguchi
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  8. Masahiro Hayashi
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  9. Tadaaki Ito
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Contributions

RS and HY analyzed the extracted data, contributed to writing the paper, and were involved in the treatment; ST and DI reviewed the study design and contributed to writing the paper; IN, YK, HF, GY, NU, and MH were involved in the treatment and contributed to writing the paper.

Corresponding author

Correspondence to Hisashi Yamamoto.

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The authors declare no conflict of financial interests.

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Shimano, R., Yamamoto, H., Nasu, I. et al. Comparison between filgrastim biosimilar and filgrastim original for the management of neutropenia after salvage chemotherapy for malignant lymphoma. Int J Hematol 116, 856–862 (2022). https://doi.org/10.1007/s12185-022-03438-1

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  • DOI: https://doi.org/10.1007/s12185-022-03438-1

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