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SF3B1 and IGHV gene mutation status predict poor prognosis in Japanese CLL patients

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Abstract

The incidence of chronic lymphocytic leukemia (CLL) is low in Japan. The clinical course ranges from very indolent to rapidly progressive. Recently, several reports have indicated that mutation of the splicing factor 3b, subunit 1 (SF3B1) gene in CLL is predictive of a poor prognosis. Here, we investigated the SF3B1 mutational status of Japanese CLL patients and clarified the association between SF3B1 mutational status and prognostic factors. One hundred and two patients that were referred to our institutions between 1999 and 2013 were enrolled. Mutation analysis of SF3B1 (n = 87) and of the immunoglobulin heavy chain gene (IGHV) (n = 102) was performed at diagnosis. FISH analysis of del(11)(q22) was performed for 17 patients. Seven patients have SF3B1 mutation (8.0 %: K700E, 5/7; G742D, 1/7 and Y623C, 1/7). The median survival times for patients with mutated and non-mutated SF3B1 were 53 and 130 months, respectively. Overall survival of the mutated SF3B1 group was significantly lower than that of the non-mutated group (p = 0.0187). No relationship was observed between IGHV mutational status and SF3B1 mutation. There was no patient with SF3B1 mutation in the IGHV1-69 population (0/2). In conclusion, mutation of SF3B1 at diagnosis in Japanese CLL patients is predictive of a poor prognosis.

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Acknowledgments

This study was supported in part by a Grant-in-Aid for Scientific Research (C), and by the National Cancer Research and Development Fund (26-A-4).

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Authors and Affiliations

  1. Department of Medicine and Clinical Sciences, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan

    Takeki Mitsui, Hirotaka Nakahashi, Hiroaki Shimizu, Takuma Ishizaki, Yoshiyuki Ogawa, Makiko Takizawa, Hiroshi Handa & Yoshihisa Nojima

  2. Oncology Center, Gunma University Hospital, Maebashi, Japan

    Hiromi Koiso & Norifumi Tsukamoto

  3. Fujioka General Hospital, Fujioka, Japan

    Akio Saitoh & Takahiro Jinbo

  4. Department of Blood Transfusion Service, Gunma University Hospital, Maebashi, Japan

    Akihiko Yokohama

  5. Department of Laboratory Sciences, Gunma University Graduate School of Health Science, Maebashi, Japan

    Takayuki Saitoh & Hirokazu Murakami

  6. Maebashi Red Cross Hospital, Maebashi, Japan

    Hidemi Ogura

  7. National Hospital Organization, Nishigunma National Hospital, Shibukawa, Japan

    Morio Sawamura

  8. Saiseikai Maebashi Hospital, Maebashi, Japan

    Tohru Sakura

  9. Usui Hospital, Annaka, Japan

    Masamitsu Karasawa

Authors
  1. Takeki Mitsui
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  2. Hiromi Koiso
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  3. Hirotaka Nakahashi
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  7. Yoshiyuki Ogawa
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  8. Makiko Takizawa
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  9. Akihiko Yokohama
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  10. Takayuki Saitoh
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  11. Takahiro Jinbo
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  12. Hidemi Ogura
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  13. Hiroshi Handa
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  14. Morio Sawamura
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  15. Tohru Sakura
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  16. Masamitsu Karasawa
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  17. Hirokazu Murakami
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  18. Yoshihisa Nojima
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  19. Norifumi Tsukamoto
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Correspondence to Takeki Mitsui.

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Mitsui, T., Koiso, H., Nakahashi, H. et al. SF3B1 and IGHV gene mutation status predict poor prognosis in Japanese CLL patients. Int J Hematol 103, 219–226 (2016). https://doi.org/10.1007/s12185-015-1912-z

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  • DOI: https://doi.org/10.1007/s12185-015-1912-z

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