Abstract
Objectives
We investigated a possible correlation between the maximum standardized uptake value (SUVmax), which is assessed by pretreatment 18F-fluorodeoxyglucose positron emission tomography with computed tomography, and the overall survival (OS) in patients with hypopharyngeal squamous cell carcinoma from two institutions on long-term follow-up, and examined whether SUVmax is correlated with several survival outcomes, including lung metastasis-free survival.
Methods
A total of 81 patients were enrolled. The survival rate was calculated by the Kaplan–Meier method. Both univariate and multivariate survival analyses were assessed by a Cox proportional hazards model.
Results
SUVmax ≥15.2 in institution A (p = 0.0306) or SUVmax ≥8 in institution B (p = 0.0132) was significantly predictor of a lower OS. We disaggregated the data by high SUVmax (SUVmax ≥15.2 from institution A and SUVmax ≥8 from institution B) and low SUVmax (SUVmax <15.2 from institution A and SUVmax <8 from institution B). Patients with a high SUVmax exhibited a significantly lower OS in both univariate (p = 0.001) and multivariate (p = 0.0046) analyses for adjusted for the clinical stage and treatment group. The patients with a high SUVmax exhibited significantly shorter disease-specific (p = 0.0068), distant metastasis-free (p = 0.0428), and lung metastasis-free (p = 0.0328) survivals.
Conclusions
High SUVmax was significantly correlated with a lower OS, disease-specific survival, distant metastasis-free survival, and lung metastasis-free survival in a multi-institutional retrospective study.
Similar content being viewed by others
References
Paidpally V, Chirindel A, Lam S, Agrawal N, Quon H, Subramaniam RM. FDG-PET/CT imaging biomarkers in head and neck squamous cell carcinoma. Imaging Med. 2012;4:633–47.
Suzuki H, Nishio M, Nakanishi H, Hanai N, Hirakawa H, Kodaira T, et al. Impact of total lesion glycolysis measured by 18F-FDG-PET/CT on overall survival and distant metastasis in hypopharyngeal cancer. Oncol Lett. 2016;12:1493–500.
Suzuki H, Kato K, Fujimoto Y, Itoh Y, Hiramatsu M, Maruo T, et al. 18F-FDG-PET/CT predicts survival in hypopharyngeal squamous cell carcinoma. Ann Nucl Med. 2013;27:297–302.
Suzuki H, Hasegawa Y, Terada A, Hyodo I, Nakashima T, Nishio M, et al. FDG-PET predicts survival and distant metastasis in oral squamous cell carcinoma. Oral Oncol. 2009;45:569–73.
Schwartz DL, Rajendran J, Yueh B, Coltera MD, Leblanc M, Eary J, et al. FDG-PET prediction of head and neck squamous cell cancer outcomes. Arch Otolaryngol Head Neck Surg. 2004;130:1361–7.
Torizuka T, Tanizaki Y, Kanno T, Futatsubashi M, Naitou K, Ueda Y, et al. Prognostic value of 18F-FDG-PET in patients with head and neck squamous cell cancer. AJR Am J Roentgenol. 2009;192:W156–60.
van Baardwijk A, Dooms C, van Suylen RJ, Verbeken E, Hochstenbag M, Dehing-Oberije C, et al. The maximum uptake of (18)F-deoxyglucose on positron emission tomography scan correlates with survival, hypoxia inducible factor-1alpha and Glut-1 in non-small cell lung cancer. Eur J Cancer. 2007;43:1392–8.
Suzuki H, Beppu S, Hanai N, Hirakawa H, Hasegawa Y. Lymph node density predicts lung metastasis in oral squamous cell carcinoma. Br J Oral Maxillofac Surg. 2016;54:213–8.
Inohara H, Enomoto K, Tomiyama Y, Higuchi I, Inoue T, Hatazawa J. Impact of FDG-PET on prediction of clinical outcome after concurrent chemoradiotherapy in hypopharyngeal carcinoma. Mol Imaging Biol. 2010;12:89–97.
Schwartz DL, Harris J, Yao M, Rosenthal DI, Opanowski A, Levering A, et al. Metabolic tumor volume as a prognostic imaging-based biomarker for head-and-neck cancer: pilot results from Radiation Therapy Oncology Group protocol 0522. Int J Radiat Oncol Biol Phys. 2015;91:721–9.
Xie P, Li M, Zhao H, Sun X, Fu Z, Yu J. 18F-FDG PET or PET–CT to evaluate prognosis for head and neck cancer: a meta-analysis. J Cancer Res Clin Oncol. 2011;131:1085–93.
Zhang B, Geng J, Nie F, Li X. Primary tumor standardized uptake value predicts survival in head and neck squamous cell carcinoma. Oncol Res Treat. 2015;38:45–8.
Takes RP, Strojan P, Silver CE, Bradley PJ, Haigentz M Jr, Wolf GT, et al. Current trends in initial management of hypopharyngeal caner: the declining use of open surgery. Head Neck. 2012;34:270–81.
Tai SK, Yang MH, Wang LW, Tsai TL, Chu PY, Wang YF, et al. Chemoradiotherapy laryngeal preservation for advanced hypopharyngeal cancer. Jpn J Clin Oncol. 2008;38:521–7.
Nakahara R, Kodaira T, Furutani K, Tachibana H, Tomita N, Inokuchi H, et al. Treatment outcomes of definitive chemoradiotherapy for patients with hypopharygneal cancer. J Radiat Res. 2012;53:906–15.
Acknowledgements
The authors would like to thank Drs. Daisuke Nishikawa, Yujiro Fukuda, Yusuke Koide, and Naoki Nishio for their stimulating discussion and valuable patient care.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no competing interests.
Rights and permissions
About this article
Cite this article
Suzuki, H., Kato, K., Nishio, M. et al. FDG-PET/CT predicts survival and lung metastasis of hypopharyngeal cancer in a multi-institutional retrospective study. Ann Nucl Med 31, 514–520 (2017). https://doi.org/10.1007/s12149-017-1176-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12149-017-1176-1