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Dual-time-point 18F-FDG PET/CT in the diagnosis of solitary pulmonary lesions in a region with endemic granulomatous diseases

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Abstract

Objective

Granulomatous diseases (GDs) can be metabolically active and indistinguishable from lung cancer on 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) imaging. Evaluation of solitary pulmonary lesions remains a diagnostic challenge in regions with endemic GD. This study sought to determine the efficacy of dual-time-point (DTP) 18F-FDG PET/computed tomography (CT) imaging in diagnosing solitary pulmonary lesions from such regions.

Methods

A total of 50 patients with solitary pulmonary nodules or masses with confirmed histopathological diagnoses underwent DTP 18F-FDG PET/CT imaging at 1 and 3 h after tracer injection. The maximum standardized uptake value (SUVmax) on early and delayed scans (SUV1h and SUV3h, respectively) and retention index (RI) were calculated for each pulmonary lesion. Receiver operating characteristic analysis was performed to evaluate the discriminating validity of the parameters.

Results

There were 37 malignant and 13 benign solitary pulmonary lesions. Eight of the 13 (62 %) benign lesions were GDs. The sensitivity/specificity/accuracy of SUV1h, SUV3h and RI were 84/69/80 %, 84/85/84 %, and 81/54/74 %, respectively. SUV3h had the best diagnostic performance, especially regarding specificity. The values of SUV1h and SUV3h were significantly different between malignant lesions and GD, while the RI values of malignant lesions and GD were both high (18.6 ± 19.5 and 18.7 ± 15.3 %, respectively; P = not significant).

Conclusion

SUV3h appeared to improve the diagnostic specificity of 18F-FDG PET/CT in evaluating solitary pulmonary lesions from regions with endemic GD.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Tungs’ Taichung MetroHarbor Hospital, No. 699, Sec. 8, Taiwan Blvd., Taichung, 435, Taiwan, ROC

    Yu-Erh Huang

  2. Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Dapi Road, Niaosong Dist., Kaohsiung, Taiwan, ROC

    Yu-Jie Huang

  3. Department of Pediatrics, Chang Gung Memorial Hospital, Chiayi, Chang Gung University College of Medicine, No. 6, West Chia-Pu Road, Putz, Chiayi County, 613, Taiwan, ROC

    Mary Ko

  4. Department of Nuclear Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Dapi Road, Niaosong Dist., Kaohsiung, Taiwan, ROC

    Chien-Chin Hsu

  5. Department of Radiology, Asia University Hospital, Asia University, No. 222, Fuxin Road, Wufeng Dist., Taichung, 41354, Taiwan, ROC

    Chih-Feng Chen

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  1. Yu-Erh Huang
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Correspondence to Chih-Feng Chen.

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Huang, YE., Huang, YJ., Ko, M. et al. Dual-time-point 18F-FDG PET/CT in the diagnosis of solitary pulmonary lesions in a region with endemic granulomatous diseases. Ann Nucl Med 30, 652–658 (2016). https://doi.org/10.1007/s12149-016-1109-4

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  • DOI: https://doi.org/10.1007/s12149-016-1109-4

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