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Metastases of Cutaneous Squamous Cell Carcinoma Seem to be the Most Frequent Malignancies in the Parotid Gland: A Hospital-Based Study From a Salivary Gland Center

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Abstract

Malignant parotid tumors account for approximately 20% of all parotid lesions. In addition to the various primary parotid lesions there are secondary parotid malignancies, such as metastases or lymphomas. Data on histopathological distribution of all malignancies—including secondary parotid lesions—is limited. Recent evidence indicated a rising surgical incidence of secondary parotid malignancies. This study aims to review the distribution of malignancies in parotid resections from a salivary gland center. A retrospective review of prospectively collected data for all patients who had received parotidectomy between 2014 and 2019 was performed. Histopathological distribution was displayed separately for all parotid malignancies and for primary parotid malignancies. Further, patients` characteristics were compared between benign and malignant parotid lesions and between the two most common malignant parotid lesions. Out of 777 patients, 614 (78.9%) patients had a benign and 164 (21.1%) patients had a malignant parotid lesion. The most common parotid malignancy was metastatic cutaneous squamous cell carcinoma (cSCC) accounting for 35.4% of all parotid malignancies. 71.5% of all malignant lesions were secondary malignancies. Patients with metastatic cSCC were significantly older (p < 0.001) and significantly more likely to be male (p < 0.001) than patients with primary parotid malignancies. No significant difference was found when the lesion size of metastatic cSCC was compared to primary parotid malignancies (p = 0.216). The present study shows the high prevalence of secondary parotid malignancies in patients who had received parotidectomy. Furthermore, it confirms a rising surgical incidence of metastatic cSCC to the parotid gland in a series from a salivary gland center. At this time, parotid surgery for malignant lesions is more likely to be performed for metastases than for primary parotid malignancies.

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Acknowledgements

The authors thank all the patients for their participation in the study.

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The authors have no funding to declare.

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Authors and Affiliations

  1. Department of Otolaryngology, University Hospital Augsburg, Sauerbruchstraße. 6, 86179, Augsburg, Germany

    M. Mayer, R. Thoelken, M. Jering & J. Zenk

  2. Institute of Pathology and Molecular Diagnostics, University Hospital Augsburg, Stenglinstraße 2, 86156, Augsburg, Germany

    B. Märkl

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  1. M. Mayer
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  2. R. Thoelken
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  3. M. Jering
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  4. B. Märkl
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  5. J. Zenk
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Correspondence to M. Mayer.

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All procedures performed in this study were in accordance with the ethical standards of the institution or practice at which the studies were conducted.

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Informed consent was obtained from all individual participants included in this study (no identifying information about participants is available in this article).

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Mayer, M., Thoelken, R., Jering, M. et al. Metastases of Cutaneous Squamous Cell Carcinoma Seem to be the Most Frequent Malignancies in the Parotid Gland: A Hospital-Based Study From a Salivary Gland Center. Head and Neck Pathol 15, 843–851 (2021). https://doi.org/10.1007/s12105-021-01294-9

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  • DOI: https://doi.org/10.1007/s12105-021-01294-9

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