Skip to main content

Advertisement

SpringerLink
Log in

Salivary-Like Tumors of the Thyroid: A Comprehensive Review of Three Rare Carcinomas

  • Review
  • Published:
Head and Neck Pathology Aims and scope Submit manuscript

Abstract

Thyroid carcinomas represent 3.2% of all new cases of cancer in the United States. Whereas most thyroid tumors arise from follicular cells or, less commonly, parafollicular cells, the derivation of some rare primary thyroid carcinoma subtypes is less clear and represents an area of evolving knowledge. Primary thyroid carcinomas that resemble neoplasms characteristic of the salivary glands (“salivary-like” primary thyroid carcinomas) arguably represent some of the most unusual primary thyroid tumors. Herein, we have undertaken a review of the literature in order to present a comprehensive overview of salivary-like primary thyroid carcinomas including: mucoepidermoid carcinoma, sclerosing mucoepidermoid carcinoma with eosinophilia, and secretory carcinoma. Awareness of these unusual, distinct primary tumors is important for timely diagnosis and optimal patient management. This review highlights these three salivary-like carcinomas, with special emphasis on developments since publication of the World Health Organization (WHO) 2017 Classification of Tumours of Endocrine Organs.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Cabanillas ME, McFadden DG, Durante C. Thyroid cancer. Lancet. 2016;388:2783–95.

    CAS  PubMed  Google Scholar 

  2. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69:7–34.

    Google Scholar 

  3. De Crea C, Raffaelli M, Sessa L, Ronti S, Fadda G, Bellantone C, et al. Actual incidence and clinical behaviour of follicular thyroid carcinoma: an institutional experience. Sci World J. 2014;2014:952095.

    Google Scholar 

  4. Tallini G, Asiolo S, Aubert S, Carcangui M, Chernock R, Fellagara G. Poorly differentiated thyroid carcinoma. In: Lloyd RV, Osamura RY, Kloppel G, Rosai J, editors. WHO classify tumours endocr glands. 4th ed. Lyon: IARC Press; 2017. p. 100–103.

    Google Scholar 

  5. El-Naggar A, Baloch Z, Eng C, Evans H, Fargin J, Faquin W. Anaplastic thyroid carcinoma. In: Lloyd RV, Osamura RY, Kloppel G, Rosai J, editors. WHO classify tumours endocr glands. 4th ed. Lyon: IARC Press; 2017. p. 104–106.

    Google Scholar 

  6. Wiltshire JJ, Drake TM, Uttley L, Balasubramanian SP. Systematic review of trends in the incidence rates of thyroid cancer. Thyroid. 2016;26:1541–52.

    PubMed  Google Scholar 

  7. International Agency for Research on Cancer. WHO classification of tumours of endocrine organs. Lyon: International Agency for Research on Cancer; 2017.

    Google Scholar 

  8. Wenig BM. Atlas of head and neck pathology. Amsterdam: Elsevier Health Sciences; 2016.

    Google Scholar 

  9. Nosé V. Diagnostic pathology: endocrine. 2nd ed. Philadelphia, PA: Elsevier; 2018.

    Google Scholar 

  10. Cameselle-Teijeiro J, Albores-Saavedra J, Baloch ZW, Sobrinho-Simões M, Wenig BM. Mucoepidermoid carcinoma. In: Lloyd RV, Osamura RY, Kloppel G, Rosai J, editors. WHO classify tumours endocr glands. 4th ed. Lyon: IARC Press; 2017. p. 117–118.

    Google Scholar 

  11. Jayakody NS, Faoury M, Fraser LR, Jogai S, Patel NN. Composite poorly differentiated mucoepidermoid carcinoma of the thyroid and follicular variant of papillary thyroid carcinoma. Report of a case and review of the literature. J Surg Case Rep. 2019. https://doi.org/10.1093/jscr/rjz092.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Farhat NA, Faquin WC, Sadow PM. Primary mucoepidermoid carcinoma of the thyroid gland: a report of three cases and review of the literature. Endocr Pathol. 2013;24:229–33.

    PubMed  Google Scholar 

  13. Wenig BM, Adair CF, Heffess CS. Primary mucoepidermoid carcinoma of the thyroid gland: a report of six cases and a review of the literature of a follicular epithelial-derived tumor. Hum Pathol. 1995;26:1099–108.

    CAS  PubMed  Google Scholar 

  14. Steele SR, Royer M, Brown TA, Porter C, Azarow KS. Mucoepidermoid carcinoma of the thyroid gland: a case report and suggested surgical approach. Am Surg. 2001;67:979–83.

    CAS  PubMed  Google Scholar 

  15. Rhatigan RM, Roque JL, Bucher RL. Mucoepidermoid carcinoma of the thyroid gland. Cancer. 1977;39:210–4.

    CAS  PubMed  Google Scholar 

  16. Franssila KO, Harach HR, Wasenius VM. Mucoepidermoid carcinoma of the thyroid. Histopathology. 1984;8:847–60.

    CAS  PubMed  Google Scholar 

  17. Mizukami Y, Matsubara F, Hashimoto T, Haratake J, Terahata S, Noguchi M, et al. Primary mucoepidermoid carcinoma in the thyroid gland. A case report including an ultrastructural and biochemical study. Cancer. 1984;53:1741–5.

    CAS  PubMed  Google Scholar 

  18. Harach HR, Day ES, de Strizic NA. Mucoepidermoid carcinoma of the thyroid. Report of a case with immunohistochemical studies. Medicina (Mex). 1986;46:213–6.

    CAS  Google Scholar 

  19. Katoh R, Sugai T, Ono S, Takayama K, Tomichi N, Kurihara H, et al. Mucoepidermoid carcinoma of the thyroid gland. Cancer. 1990;65:2020–7.

    CAS  PubMed  Google Scholar 

  20. Larson RS, Wick MR. Primary mucoepidermoid carcinoma of the thyroid: diagnosis by fine-needle aspiration biopsy. Diagn Cytopathol. 1993;9:438–43.

    CAS  PubMed  Google Scholar 

  21. Cameselle-Teijeiro J, Febles-Pérez C, Sobrinho-Simões M. Papillary and mucoepidermoid carcinoma of the thyroid with anaplastic transformation: a case report with histologic and immunohistochemical findings that support a provocative histogenetic hypothesis. Pathol Res Pract. 1995;191:1214–21.

    CAS  PubMed  Google Scholar 

  22. Arezzo A, Patetta R, Ceppa P, Borgonovo G, Torre G, Mattioli FP. Mucoepidermoid carcinoma of the thyroid gland arising from a papillary epithelial neoplasm. Am Surg. 1998;64:307–11.

    CAS  PubMed  Google Scholar 

  23. Vázquez Ramírez F, Otal Salaverri C, Argueta Manzano O, Galera Ruíz H, González-Cámpora R. Fine needle aspiration cytology of high grade mucoepidermoid carcinoma of the thyroid: a case report. Acta Cytol. 2000;44:259–64.

    PubMed  Google Scholar 

  24. Baloch ZW, Solomon AC, LiVolsi VA. Primary mucoepidermoid carcinoma and sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid gland: a report of nine cases. Mod Pathol. 2000;13:802–7.

    CAS  PubMed  Google Scholar 

  25. Minagawa A, Iitaka M, Suzuki M, Yasuda S, Kameyama K, Shimada S, et al. A case of primary mucoepidermoid carcinoma of the thyroid: molecular evidence of its origin. Clin Endocrinol (Oxf). 2002;57:551–6.

    Google Scholar 

  26. Bhandarkar ND, Chan J, Strome M. A rare case of mucoepidermoid carcinoma of the thyroid. Am J Otolaryngol. 2005;26:138–41.

    PubMed  Google Scholar 

  27. Ando M, Nakanishi Y, Asai M, Maeshima A, Matsuno Y. Mucoepidermoid carcinoma of the thyroid gland showing marked ciliation suggestive of its pathogenesis. Pathol Int. 2008;58:741–4.

    PubMed  Google Scholar 

  28. Jung YH, Kang MS. Composite follicular variant of papillary carcinoma and mucoepidermoid carcinoma of thyroid gland: a case report. J Korean Med Sci. 2010;25:1683–7.

    PubMed  PubMed Central  Google Scholar 

  29. Shindo K, Aishima S, Okido M, Ohshima A. A poor prognostic case of mucoepidermoid carcinoma of the thyroid: a case report. Case Rep Endocrinol. 2012;2012:862545.

    PubMed  PubMed Central  Google Scholar 

  30. Prichard RS, Lee JC, Gill AJ, Sywak MS, Fingleton L, Robinson BG, et al. Mucoepidermoid carcinoma of the thyroid: a report of three cases and postulated histogenesis. Thyroid. 2012;22:205–9.

    PubMed  Google Scholar 

  31. Nath V, Parks GE, Baliga M, Hartle EO, Geisinger KR, Shenoy V. Mucoepidermoid carcinoma of the thyroid with concomitant papillary carcinoma: comparison of findings on fine-needle aspiration biopsy and histology. Endocr Pathol. 2014;25:427–32.

    PubMed  Google Scholar 

  32. Fulciniti F, Vuttariello E, Calise C, Monaco M, Pezzullo L, Chiofalo MG, et al. Combined papillary and mucoepidermoid carcinoma of the thyroid gland: a possible collision tumor diagnosed on fine-needle cytology: Report of a case with immunocytochemical and molecular correlations. Endocr Pathol. 2015;26:140–4.

    PubMed  Google Scholar 

  33. Taconet S, Bosq J, Hartl D, Schlumberger M, Leboulleux S, Scoazec J-Y, et al. Composite mucoepidermoid carcinoma and columnar cell variant of papillary carcinoma of the thyroid: a case report and review of the literature. Int J Surg Pathol. 2016;24:336–40.

    CAS  PubMed  Google Scholar 

  34. Le QV, Ngo DQ, Ngo QX. Primary mucoepidermoid carcinoma of the thyroid: a report of a rare case with bone metastasis and review of the literature. Case Rep Oncol. 2019;12:248–59.

    PubMed  PubMed Central  Google Scholar 

  35. Cameselle-Teijeiro J, Febles-Pérez C, Sobrinho-Simões M. Cytologic features of fine needle aspirates of papillary and mucoepidermoid carcinoma of the thyroid with anaplastic transformation: a case report. Acta Cytol. 1997;41:1356–60.

    CAS  PubMed  Google Scholar 

  36. Tanda F, Massareui G, Bosincu L. Primary mucoepidermoid carcinoma of the thyroid. Surg Pathol. 2000;3:317–24.

    Google Scholar 

  37. Obidike S, Aftab F. Rare case of mucoepidermoid carcinoma of the thyroid gland. Thyroid Disord Ther. 2016;5:199.

    Google Scholar 

  38. Bondeson L, Bondeson AG, Thompson NW. Papillary carcinoma of the thyroid with mucoepidermoid features. Am J Clin Pathol. 1991;95:175–9.

    CAS  PubMed  Google Scholar 

  39. Wenig BM. Mucoepidermoid carcinoma: atlas head neck pathology. Elsevier Health Sciences: Philadelphia, PA; 2016. p. 924–936.

    Google Scholar 

  40. Bajja MY, Benassila FZ, Abada RL, Mahtar M, Chadli A. Mucinous carcinoma of the thyroid: a case report and review of the literature. Ann Endocrinol. 2017;78:70–3.

    Google Scholar 

  41. Tirado Y, Williams MD, Hanna EY, Kaye FJ, Batsakis JG, El-Naggar AK. CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin’s tumors: implications for histogenesis and biologic behavior. Genes Chromosom Cancer. 2007;46:708–15.

    CAS  PubMed  Google Scholar 

  42. Warner E, Ofo E, Connor S, Odell E, Jeannon JP. Mucoepidermoid carcinoma in a thyroglossal duct remnant. Int J Surg Case Rep. 2015;13:43–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  43. Trovisco V, Vieira de Castro I, Soares P, Máximo V, Silva P, Magalhães J, et al. BRAF mutations are associated with some histological types of papillary thyroid carcinoma. J Pathol. 2004;202:247–51.

    CAS  PubMed  Google Scholar 

  44. Cretney A, Mow C. Mucinous variant of follicular carcinoma of the thyroid gland. Pathology (Phila). 2006;38:184–6.

    Google Scholar 

  45. Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, et al. 2015 American Thyroid Association Management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association Guidelines Task Force on thyroid nodules and differentiated thyroid cancer. Thyroid. 2015;26:1–133.

    Google Scholar 

  46. Sobrinho-Simões M, Albores-Saavedra J, Chan JK, El-Naggar AK, Geisinger KR, LiVolsi VA. Sclerosing mucoepidermoid carcinoma with eosinophilia. In: Lloyd RV, Osamura RY, Kloppel G, Rosai J, editors. WHO Classify Tumours Endocr Glands. 4th ed. Lyon: IARC Press; 2017. p. 119–120.

    Google Scholar 

  47. Nosé V. Sclerosing mucoepidermoid carcinoma with eosinophilia. In: Nosé V, editor. Diagnostic pathology: endocrine. 2nd ed. Philadelphia, PA: Elsevier; 2018. p. 266–273.

    Google Scholar 

  48. Chan JK, Albores-Saavedra J, Battifora H, Carcangiu ML, Rosai J. Sclerosing mucoepidermoid thyroid carcinoma with eosinophilia: a distinctive low-grade malignancy arising from the metaplastic follicles of Hashimoto’s thyroiditis. Am J Surg Pathol. 1991;15:438–48.

    CAS  PubMed  Google Scholar 

  49. Bondeson L, Bondeson AG. Cytologic features in fine-needle aspirates from a sclerosing mucoepidermoid thyroid carcinoma with eosinophilia. Diagn Cytopathol. 1996;15:301–5.

    CAS  PubMed  Google Scholar 

  50. Sim SJ, Ro JY, Ordonez NG, Cleary KR, Ayala AG. Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: report of two patients, one with distant metastasis, and review of the literature. Hum Pathol. 1997;28:1091–6.

    CAS  PubMed  Google Scholar 

  51. Geisinger KR, Steffee CH, McGee RS, Woodruff RD, Buss DH. The cytomorphologic features of sclerosing mucoepidermoid carcinoma of the thyroid gland with eosinophilia. Am J Clin Pathol. 1998;109:294–301.

    CAS  PubMed  Google Scholar 

  52. Chung J, Lee SK, Gong G, Kang DY, Park JH, Kim SB, et al. Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid glands: a case report with clinical manifestation of recurrent neck mass. J Korean Med Sci. 1999;14:338–41.

    CAS  PubMed  PubMed Central  Google Scholar 

  53. Solomon AC, Baloch ZW, Salhany KE, Mandel S, Weber RS, LiVolsi VA. Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia: mimic of Hodgkin disease in nodal metastases. Arch Pathol Lab Med. 2000;124:446–9.

    CAS  PubMed  Google Scholar 

  54. Albores-Saavedra J, Gu X, Luna MA. Clear cells and thyroid transcription factor I reactivity in sclerosing mucoepidermoid carcinoma of the thyroid gland. Ann Diagn Pathol. 2003;7:348–53.

    PubMed  Google Scholar 

  55. Sharma K, Nigam S, Khurana N, Chaturvedi KU. Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid—a case report. Indian J Pathol Microbiol. 2003;46:660–1.

    PubMed  Google Scholar 

  56. Hunt JL, LiVolsi VA, Barnes EL. p63 expression in sclerosing mucoepidermoid carcinomas with eosinophilia arising in the thyroid. Mod Pathol. 2004;17:526–9.

    PubMed  Google Scholar 

  57. Shehadeh NJ, Vernick J, Lonardo F, Madan SK, Jacobs JR, Yoo GH, et al. Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: a case report and review of the literature. Am J Otolaryngol. 2004;25:48–53.

    PubMed  Google Scholar 

  58. Das S, Kalyani R. Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid. Indian J Pathol Microbiol. 2008;51:34–6.

    CAS  PubMed  Google Scholar 

  59. Frazier WD, Patel NP, Sullivan CA. Pathology quiz case 1 Sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE). Arch Otolaryngol Head Neck Surg. 2008;134:333–5.

    PubMed  Google Scholar 

  60. Lai C-Y, Chao T-C, Lin J-D, Hsueh C. Sclerosing mucoepidermoid carcinoma with eosinophilia of thyroid gland in a male patient: a case report and literature review. Int J Clin Exp Pathol. 2015;8:5947–51.

    PubMed  PubMed Central  Google Scholar 

  61. Quiroga-Garza G, Lee JH, El-Naggar A, Black JO, Amrikachi M, Zhai QJ, et al. Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: more aggressive than previously reported. Hum Pathol. 2015;46:725–31.

    PubMed  Google Scholar 

  62. Shah AA, La Fortune K, Miller C, Mills SE, Baloch Z, LiVolsi V, et al. Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia: a clinicopathologic and molecular analysis of a distinct entity. Mod Pathol. 2017;30:329–39.

    CAS  PubMed  Google Scholar 

  63. Ames E, Campbell MJ, Afify A, Krane JF, Huang EC. Sclerosing mucoepidermoid carcinoma with eosinophilia: cytologic characterization of a rare distinct entity in the thyroid. Diagn Cytopathol. 2018;46:632–5.

    PubMed  Google Scholar 

  64. Hirokawa M, Takada N, Abe H, Suzuki A, Higuchi M, Miya A, et al. Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia distinct from the salivary type. Endocr J. 2018;65:427–36.

    CAS  PubMed  Google Scholar 

  65. Raveendran Nair AKA, George NA, Kumar R, Sreekumar A, Jayasree K. Sclerosing mucoepidermoid carcinoma with eosinophilia of thyroid gland: not so indolent a neoplasm? Indian J Pathol Microbiol. 2018;61:242–4.

    PubMed  Google Scholar 

  66. Wiles AB, Kraft AO, Mueller SM, Powers CN. Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: case report of a rare lesion with novel genetic mutation. Diagn Cytopathol. 2019;47:589–93.

    PubMed  Google Scholar 

  67. Calò PG, Maxia S, Lai ML, Nicolosi A, Ribuffo D. Sclerosing mucoepidermoid thyroid carcinoma requiring cervical reconstruction: a case report and review of the literature. Am Surg. 2010;76:918–9.

    PubMed  Google Scholar 

  68. Pantola C, Kala S, Athar M, Thakur S. Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: a cytological dilemma. J Cytol. 2016;33:37–9.

    PubMed  PubMed Central  Google Scholar 

  69. Geisinger KR, Hartle EO, Warren T. Eosinophilic replacement infiltrates in cystic Hashimoto’s thyroiditis: a potential diagnostic pitfall. Endocr Pathol. 2014;25:332–8.

    PubMed  Google Scholar 

  70. Musso-Lassalle S, Butori C, Bailleux S, Santini J, Franc B, Hofman P. A diagnostic pitfall: nodular tumor-like squamous metaplasia with Hashimoto’s thyroiditis mimicking a sclerosing mucoepidermoid carcinoma with eosinophilia. Pathol Res Pract. 2006;202:379–83.

    PubMed  Google Scholar 

  71. Ryska A, Ludvíková M, Rydlová M, Cáp J, Zalud R. Massive squamous metaplasia of the thyroid gland–report of three cases. Pathol Res Pract. 2006;202:99–106.

    PubMed  Google Scholar 

  72. Skálová A, Vanecek T, Sima R, Laco J, Weinreb I, Perez-Ordonez B, et al. Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity. Am J Surg Pathol. 2010;34:599–608.

    PubMed  Google Scholar 

  73. Seethala RR, Stenman G. Update from the 4th edition of the World Health Organization classification of head and neck tumours: tumors of the salivary gland. Head Neck Pathol. 2017;11:55–67.

    PubMed  PubMed Central  Google Scholar 

  74. Skálová A, Bell D, Bishop J, Inagaki H, Seethala R, Vielh P. Secretory carcinoma. In: El-Naggar AK, Chan JC, Gd JR, Takata T, Slootweg PJ, editors. WHO classify head neck tumours. 4th ed. Lyon: IARC Press; 2017. p. 177–178.

    Google Scholar 

  75. Desai MA, Mehrad M, Ely KA, Bishop JA, Netterville J, Aulino JM, et al. Secretory carcinoma of the thyroid gland: report of a highly aggressive case clinically mimicking undifferentiated carcinoma and review of the literature. Head Neck Pathol. 2019;13:562–72.

    PubMed  Google Scholar 

  76. Reynolds S, Shaheen M, Olson G, Barry M, Wu J, Bocklage T. A case of primary mammary analog secretory carcinoma (MASC) of the thyroid masquerading as papillary thyroid carcinoma: potentially more than a one off. Head Neck Pathol. 2016;10:405–13.

    CAS  PubMed  PubMed Central  Google Scholar 

  77. Dogan S, Wang L, Ptashkin RN, Dawson RR, Shah JP, Sherman EJ, et al. Mammary analog secretory carcinoma of the thyroid gland: a primary thyroid adenocarcinoma harboring ETV6-NTRK3 fusion. Mod Pathol. 2016;29:985–95.

    CAS  PubMed  PubMed Central  Google Scholar 

  78. Dettloff J, Seethala RR, Stevens TM, Brandwein-Gensler M, Centeno BA, Otto K, et al. Mammary analog secretory carcinoma (MASC) involving the thyroid gland: a report of the first 3 cases. Head Neck Pathol. 2017;11:124–30.

    PubMed  Google Scholar 

  79. Liao H, Khan A, Miron PM, Cornejo KM. Mammary analogue secretory carcinoma of the thyroid mimicking locally advanced papillary thyroid carcinoma: a rare case report. Int J Surg Pathol. 2018;26:459–63.

    PubMed  Google Scholar 

  80. Asa SL, Mete O. An unusual salivary gland tumor mimicking papillary thyroid carcinoma: mammary analog secretory carcinoma. Front Endocrinol. 2018;9:555.

    Google Scholar 

  81. Farhat NA, Onenerk AM, Krane JF, Dias-Santagata D, Sadow PM, Faquin WC. Primary benign and malignant thyroid neoplasms with signet ring cells: cytologic, histologic, and molecular features. Am J Clin Pathol. 2017;148:251–8.

    CAS  PubMed  Google Scholar 

  82. Rodríguez-Urrego PA, Dogan S, Lin O. Cytologic findings of mammary analogue secretory carcinoma arising in the thyroid. Diagn Cytopathol. 2017;45:552–6.

    PubMed  Google Scholar 

  83. Rupp AP, Bocklage TJ. Mammary analog secretory carcinoma of thyroid: a case report. Diagn Cytopathol. 2017;45:45–50.

    PubMed  Google Scholar 

  84. Stevens TM, Kovalovsky AO, Velosa C, Shi Q, Dai Q, Owen RP, et al. Mammary analog secretory carcinoma, low-grade salivary duct carcinoma, and mimickers: a comparative study. Mod Pathol. 2015;28:1084–100.

    CAS  PubMed  Google Scholar 

  85. Wu EY, Lebastchi J, Marqusee E, Lorch JH, Krane JF, Barletta JA. A case of primary secretory carcinoma of the thyroid with high-grade features. Histopathology. 2017;71:665–9.

    PubMed  PubMed Central  Google Scholar 

  86. Solomon JP, Benayed R, Hechtman JF, Ladanyi M. Identifying patients with NTRK fusion cancer. Ann Oncol. 2019;30:16–22.

    Google Scholar 

  87. Prasad ML, Vyas M, Horne MJ, Virk RK, Morotti R, Liu Z, et al. NTRK fusion oncogenes in pediatric papillary thyroid carcinoma in northeast United States. Cancer. 2016;122:1097–107.

    CAS  PubMed  Google Scholar 

  88. Tognon C, Knezevich SR, Huntsman D, Roskelley CD, Melnyk N, Mathers JA, et al. Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma. Cancer Cell. 2002;2:367–76.

    CAS  PubMed  Google Scholar 

  89. Eguchi M, Eguchi-Ishimae M, Tojo A, Morishita K, Suzuki K, Sato Y, et al. Fusion of ETV6 to neurotrophin-3 receptor TRKC in acute myeloid leukemia with t(12;15)(p13;q25). Blood. 1999;93:1355–63.

    CAS  PubMed  Google Scholar 

  90. Rubin BP, Chen CJ, Morgan TW, Xiao S, Grier HE, Kozakewich HP, et al. Congenital mesoblastic nephroma t(12;15) is associated with ETV6-NTRK3 gene fusion: cytogenetic and molecular relationship to congenital (infantile) fibrosarcoma. Am J Pathol. 1998;153:1451–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  91. Knezevich SR, McFadden DE, Tao W, Lim JF, Sorensen PH. A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma. Nat Genet. 1998;18:184–7.

    CAS  PubMed  Google Scholar 

  92. Seethala RR, Chiosea SI, Liu CZ, Nikiforova M, Nikiforov YE. Clinical and morphologic features of ETV6-NTRK3 translocated papillary thyroid carcinoma in an adult population without radiation exposure. Am J Surg Pathol. 2017;41:446–57.

    PubMed  PubMed Central  Google Scholar 

  93. Leeman-Neill RJ, Kelly LM, Liu P, Brenner AV, Little MP, Bogdanova TI, et al. ETV6-NTRK3 is a common chromosomal rearrangement in radiation-associated thyroid cancer. Cancer. 2014;120:799–807.

    CAS  PubMed  Google Scholar 

  94. Ito Y, Ishibashi K, Masaki A, Fujii K, Fujiyoshi Y, Hattori H, et al. Mammary analogue secretory carcinoma of salivary glands: a clinicopathologic and molecular study including 2 cases harboring ETV6-X fusion. Am J Surg Pathol. 2015;39:602–10.

    PubMed  Google Scholar 

  95. Skálová A, Vanecek T, Simpson RHW, Laco J, Majewska H, Baneckova M, et al. Mammary analogue secretory carcinoma of salivary glands: molecular analysis of 25 ETV6 gene rearranged tumors with lack of detection of classical ETV6-NTRK3 fusion transcript by standard RT-PCR: report of 4 cases harboring ETV6-X gene fusion. Am J Surg Pathol. 2016;40:3–13.

    PubMed  Google Scholar 

  96. Otsubo R, Mussazhanova Z, Akazawa Y, Sato A, Matsuda K, Matsumoto M, et al. Sporadic pediatric papillary thyroid carcinoma harboring the ETV6/NTRK3 fusion oncogene in a 7-year-old Japanese girl: a case report and review of literature. J Pediatr Endocrinol Metab. 2018;31:461–7.

    PubMed  Google Scholar 

  97. Skálová A, Vanecek T, Martinek P, Weinreb I, Stevens TM, Simpson RHW, et al. molecular profiling of mammary analog secretory carcinoma revealed a subset of tumors harboring a novel ETV6-RET translocation: report of 10 cases. Am J Surg Pathol. 2018;42:234–46.

    PubMed  Google Scholar 

  98. Drilon A, Li G, Dogan S, Gounder M, Shen R, Arcila M, et al. What hides behind the MASC: clinical response and acquired resistance to entrectinib after ETV6-NTRK3 identification in a mammary analogue secretory carcinoma (MASC). Ann Oncol. 2016;27:920–6.

    CAS  PubMed  PubMed Central  Google Scholar 

  99. Carpenter GR, Emery JL. Inclusions in the human thyroid. J Anat. 1976;122:77–89.

    CAS  PubMed  PubMed Central  Google Scholar 

  100. Levy GH, Marti JL, Cai G, Kayne RD, Udelsman R, Hammers LW, et al. Pleomorphic adenoma arising in an incidental midline isthmic thyroid nodule: a case report and review of the literature. Hum Pathol. 2012;43:134–7.

    PubMed  Google Scholar 

Download references

Funding

None.

Author information

Authors and Affiliations

  1. Department of Pathology, Dartmouth-Hitchcock Medical Center, One Medical Center Dr, Lebanon, NH, 03756, USA

    Meagan Chambers, Laura J. Tafe & Darcy A. Kerr

  2. Geisel School of Medicine at Dartmouth, Hanover, NH, USA

    Meagan Chambers, Laura J. Tafe & Darcy A. Kerr

  3. Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

    Vânia Nosé & Peter M. Sadow

Authors
  1. Meagan Chambers
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Vânia Nosé
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Peter M. Sadow
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Laura J. Tafe
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Darcy A. Kerr
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Darcy A. Kerr.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Electronic supplementary material

Below is the link to the electronic supplementary material.

12105_2020_1193_MOESM1_ESM.png

Online Resource 1: Published Cases of Mucoepidermoid Carcinoma. Legend for Online Resource 1: F = female. M = male. NA = not available. PTC = papillary thyroid carcinoma. FTC = follicular thyroid carcinoma. AWD = alive with disease. ANED = alive, no evidence of disease. DOD = dead of disease. TG = thyroglobulin. PAS-alc = periodic acid-Schiff with alcian blue. NOS = not otherwise specified. Italics indicate disease progression or recurrence after initial treatment. (PNG 2214 kb)

12105_2020_1193_MOESM2_ESM.png

Online Resource 2: Sclerosing Mucoepidermoid Carcinoma with Eosinophilia. Legend for Online Resource 2: F = female. M = male. NA = not available. PTC = papillary thyroid carcinoma. AWD = alive with disease. ANED = alive, no evidence of disease. DOD = dead of disease. TG = thyroglobulin. PAS-alc = periodic acid-Schiff with alcian blue. NOS = not otherwise specified. Italics indicate disease progression or recurrence after initial treatment. (PNG 2263 kb)

12105_2020_1193_MOESM3_ESM.png

Online Resource 3: Published Cases of Secretory Carcinoma.Legend for Online Resource 3: F = female. M = male. NA = not available. PTC = papillary thyroid carcinoma. AWD = alive with disease. ANED = alive, no evidence of disease. DOD = dead of disease. TG = thyroglobulin. PAS-alc = periodic acid-Schiff with alcian blue. AR = androgen receptor. NOS = not otherwise specified. Italics indicate disease progression or recurrence after initial treatment. (PNG 1145 kb)

Electronic supplementary material 4 (XLSX 26 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chambers, M., Nosé, V., Sadow, P.M. et al. Salivary-Like Tumors of the Thyroid: A Comprehensive Review of Three Rare Carcinomas. Head and Neck Pathol 15, 212–224 (2021). https://doi.org/10.1007/s12105-020-01193-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12105-020-01193-5

Keywords

Search

Navigation