Abstract
Synchronous ipsilateral tumor formation within a major salivary gland is a very rare event. In this case, a 54-year-old female tobacco smoker presented with a slowly enlarging left parotid gland. Computed tomography of the neck demonstrated a solid mass superficial to a cystic mass in the deep lobe of the gland. Ultrasound-guided fine needle aspiration yielded oncocytic cells, lymphoid cells, and granular debris along with rare cohesive groups of basaloid cells. Parotidectomy was performed, and the resected gland was found to contain two adjacent but distinct masses. One mass, a predominantly solid, well-circumscribed lesion composed of ribbons of double-layered oncocytic cells and a lymphoid stroma with germinal center formation, was a Warthin tumor. The other mass, a predominantly cystic lesion composed of cords and nests of basaloid cells with associated deposits of basement membrane-like material, was a basal cell adenoma of the membranous type. To our knowledge, this is the first reported case of synchronous Warthin tumor and basal cell adenoma of the parotid gland with cytologic–histologic correlation attributable to each tumor.
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References
Parwani AV, Ali SZ. Diagnostic accuracy and pitfalls in fine-needle aspiration interpretation of Warthin tumor. Cancer Cytopathol. 2003;99:166–71.
Yoo GH, Eisele DW, Askin FB, Driben JS, Johns ME. Warthin’s tumor: a 40-year experience at the Johns Hopkins Hospital. Laryngoscope. 1994;104:799–803.
Veder LL, Kerrebijn JD, Smedts FM, den Bakker MA. Diagnostic accuracy of fine-needle aspiration cytology in Warthin tumors. Head Neck. 2010;32:1635–40.
Kawata R, Yoshimura K, Lee K, Araki M, Takenaka H, Tsuji M. Basal cell adenoma of the parotid gland: a clinicopathological study of nine cases–basal cell adenoma versus pleomorphic adenoma and Warthin’s tumor. Eur Arch Otorhinolaryngol. 2010;267:779–83.
Zarbo RJ. Salivary gland neoplasia: a review for the practicing pathologist. Mod Pathol. 2002;15:298–323.
Mukunyadzi P. Review of fine-needle aspiration cytology of salivary gland neoplasms, with emphasis on differential diagnosis. Am J Clin Pathol. 2002;118:S100–15.
Gupta N, Bal A, Gupta AK, Rajwanshi A. Basal cell adenoma: a diagnostic dilemma on fine needle aspiration cytology. Diagn Cytopathol. 2011;39:913–6.
Bhat A, Rao M, Geethamani V, Shetty AC. Basal cell adenoma of the parotid gland: cytological diagnosis of an uncommon tumor. J Oral Maxillofac Pathol. 2015;19:106.
Gnepp DR, Schroeder W, Heffner D. Synchronous tumors arising in a single major salivary gland. Cancer. 1989;63:1219–24.
Goh PM, Cheah E. Synchronous tumours of the parotid gland with different histology. Br J Oral Maxillofac Surg. 1989;27:198–202.
Scheller EL, Pritchett CV, Shukla A, Pepper JP, Marentette LJ, McHugh JB. Synchronous ipsilateral sebaceous lymphadenoma and membranous basal cell adenoma of the parotid. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;115:e41–6.
Freedman LS, Oberman B, Sadetzki S. Using time-dependent covariate analysis to elucidate the relation of smoking history to Warthin’s tumor risk. Am J Epidemiol. 2009;170:1178–85.
Sadetzki S, Oberman B, Mandelzweig L, Chetrit A, Ben-Tal T, Jarus-Hakak A, Duvdevani S, Cardis E, Wolf M. Smoking and risk of parotid gland tumors: a nationwide case control study. Cancer. 2008;112:1974–82.
Joo YH, Kim JP, Park JJ, Woo SH. Two-phase helical computed tomography study of salivary gland Warthin tumors: a radiologic findings and surgical applications. Clin Exp Otorhinolaryngol. 2014;7:216–21.
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Gvozdjan, K., Groth, J.V., Patel, T.N. et al. Synchronous Ipsilateral Parotid Tumors with Cytologic–Histologic Correlation. Head and Neck Pathol 10, 265–268 (2016). https://doi.org/10.1007/s12105-015-0658-5
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DOI: https://doi.org/10.1007/s12105-015-0658-5