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Hyperandrogenism

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Abstract

Hyperandrogenism is a common condition encountered by pediatric and adolescent physicians. Most girls with hyperandrogenism represent physiological pubertal variation; pathology may be present in a substantial minority. Systematic evaluation is essential to avoid unnecessary work-up in physiological causes while not missing pathological causes. Polycystic ovarian syndrome (PCOS), unexplained, persistent hyperandrogenism of ovarian origin, is the most common form in adolescent girls. The high prevalence of physiological peripubertal hirsutism, anovulation, and polycystic ovarian morphology results in mislabeling many girls as having the polycystic ovarian syndrome, a disorder with lifelong implications. The use of strict criteria of age-specific anovulation, hyperandrogenism, and duration is essential to reduce their stigmatization. The exclusion of secondary causes by screening tests (cortisol, thyroid profile, prolactin, and 17OHP) is essential before undertaking treatment for PCOS. Lifestyle measures, estrogen-progesterone preparations, antiandrogens, and metformin are the cornerstone of managing the disorder.

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Authors and Affiliations

  1. Department of Pediatric Endocrinology, Regency Center for Diabetes Endocrinology & Research, Kanpur, U.P., India

    Vibha Yadav

  2. Department of Reproductive Medicine, Regency Hospital Limited, A2 Sarvodaya Nagar, Kanpur, U.P., 208001, India

    Yuthika Sharma

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  1. Vibha Yadav
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  2. Yuthika Sharma
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YS and VY prepared the initial draft. YS reviewed the manuscript and will act as a guarantar for this manuscript.

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Correspondence to Yuthika Sharma.

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Yadav, V., Sharma, Y. Hyperandrogenism. Indian J Pediatr 90, 1018–1024 (2023). https://doi.org/10.1007/s12098-023-04678-7

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  • DOI: https://doi.org/10.1007/s12098-023-04678-7

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