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Therapeutic Hypothermia for Perinatal Asphyxia in India—Experience and Evidence

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Abstract

Therapeutic hypothermia is an established therapy with proven benefit for term neonates with moderate and severe hypoxic–ischemic encephalopathy (HIE). Many centers in India have started therapeutic cooling of asphyxiated infants. There is enough evidence for the beneficial effect of cooling from the randomized trials conducted in India. However, the recently published hypothermia for encephalopathy in low- and middle-income countries (HELIX) trial has contrasting findings. In this context, this review is written summarizing the available experience and evidence for therapeutic hypothermia for perinatal asphyxia in India.

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Authors and Affiliations

  1. Department of Neonatology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India

    Umamaheswari B. & Prakash Amboiram

  2. Department of Neonatology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India

    B. Adhisivam

  3. Department of Pediatrics and Neonatology, Aarupadai Veedu Medical College and Hospital, Vinayaka Mission’s Research Foundation-DU, Puducherry, 609602, India

    B. Vishnu Bhat

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  1. Umamaheswari B.
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  3. B. Adhisivam
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  4. B. Vishnu Bhat
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All authors were involved in writing, and editing the manuscript. BVB will act as the guarantor for this paper.

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Correspondence to B. Vishnu Bhat.

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B., U., Amboiram, P., Adhisivam, B. et al. Therapeutic Hypothermia for Perinatal Asphyxia in India—Experience and Evidence. Indian J Pediatr 89, 804–811 (2022). https://doi.org/10.1007/s12098-022-04187-z

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  • DOI: https://doi.org/10.1007/s12098-022-04187-z

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