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Demographic Profile and Genotypic Distribution of Rotavirus Gastroenteritis from Rural Haryana, India

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Abstract

Objective

To know the prevalence of rotavirus among hospitalized <5 y children, their demographic profile and genotypic distribution of rotavirus strain from tertiary care center of rural Haryana.

Methods

An observational 3-year study done from June 2016 to June 2019 where children under 5 y of age hospitalized for acute gastroenteritis were enrolled. Various demographic, environmental, and clinical parameters were assessed. Stool samples were collected and sent to CMC, Vellore for rotavirus screening by enzyme immune assay (EIA) and RV-positive samples were genotyped using reverse transcription-polymerase chain reaction (RT-PCR).

Results

Out of 444 stool sample screened, 107 were positive (24.1%) for rotavirus. RV positive cases seen mostly in 6–24 mo age group with moderate to severe dehydration at presentation and peaks in winter months (Dec – Feb). G3P[8] (35.24%) is the most prevalent genotype identified followed by G1P[8] (20.95%), G1P[6] (11.43%), G2P[4] (6.67%) and G12P[8] (2.86%).

Conclusion

Continuous surveillance is required to monitor the circulating genotypes in postvaccination phase and assess the effectiveness and impact of the vaccine.

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Acknowledgements

The study was supported by the Indian Council of Medical Research, New Delhi; Ministry of Health and Family Welfare, Govt. of India and the State government of the participating institution.

The authors thank the team at Christian Medical College, Vellore for support, and the children and families for participation.

Funding

This work was supported by grants from the Bill and Melinda Gates Foundation to the Centers for Disease Control and Prevention, Atlanta, GA, USA (subcontract to Christian Medical College, Vellore grant no MOA#871-15SC) and the Translational Health Science and Technology Institute (grant no OPP1165083).Compliance with Ethical Standards.

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Authors and Affiliations

  1. Department of Pediatrics, B P S Govt. Medical College for Women, Khanpur Kalan, Sonepat, Haryana, India

    Manoj Rawal & Preeti Raikwar

  2. The Wellcome Trust Research Laboratory, Christian Medical College, Vellore, Tamil Nadu, India

    Nayana P. Nair, Varunkumar Thiyagarajan & Ragavi Lingam

Authors
  1. Manoj Rawal
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  2. Preeti Raikwar
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  3. Nayana P. Nair
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  4. Varunkumar Thiyagarajan
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  5. Ragavi Lingam
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Contributions

PR and MR designed and conducted the study. PR and MR acquired the data. PR, NPN, VT and RL analyzed and interpreted the data. PR wrote the first draft of the manuscript. All authors critically reviewed and accepted the final version of the manuscript. PR and NPN will act as guarantor for this paper.

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Correspondence to Preeti Raikwar.

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Rawal, M., Raikwar, P., Nair, N.P. et al. Demographic Profile and Genotypic Distribution of Rotavirus Gastroenteritis from Rural Haryana, India. Indian J Pediatr 88 (Suppl 1), 47–52 (2021). https://doi.org/10.1007/s12098-020-03612-5

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  • DOI: https://doi.org/10.1007/s12098-020-03612-5

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