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Power Color Doppler and Spectral Doppler Ultrasonography to Evaluate Response to Intra-articular Steroid Injection in Knee Joints in Juvenile Idiopathic Arthritis

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Abstract

Objective

To evaluate the role of ultrasonographic indices (Color Fraction and Resistive Index) in assessing the effect of intra-articular steroid (IAS) injection on synovial inflammation in knee joints of Juvenile Idiopathic Arthritis (JIA) patients and to determine the correlation between these ultrasonographic indices and clinical and laboratory parameters in JIA patients after IAS.

Methods

Twenty seven patients of JIA and equal number of age and sex matched healthy controls were enrolled. Thirty six knee joints were injected with IAS. Duration of morning stiffness, swelling score, tenderness score, range of motion, visual analogue scale for pain, Physician global assessment of disease activity, Patient/Parent assessment of general well being, Juvenile Arthritis Disease Activity Score, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), synovial thickness, synovial effusion, Color fraction (CF) and Resistive index (RI) were measured at base line and at one and two months of follow-up.

Results

At baseline, a significant difference was found in ESR, CRP, CF and RI values between cases and controls. A significant decrease in various clinical, core set variables and ultrasonographic parameters was observed at each follow-up. Synovial thickness, synovial effusion and CF decreased by 51.78%, 64.67% and 49.35% respectively and range of motion and RI increased by 166% and 31.94% respectively at second follow-up. Both CF and RI showed a significant correlation with active joint count. Both CF and RI had a high inter and intra-class correlation.

Conclusions

Power Color Doppler and Spectral Doppler ultrasonographic indices (CF and RI) may have a role in assessment of the response to IAS injection of inflamed knee joints.

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Authors and Affiliations

  1. Department of Pediatrics, Post Graduate Institute of Medical Education and Research and Dr. Ram Manohar Lohia Hospital, New Delhi, India

    Tapas Baikar, Amieleena Chhabra, Tribhuvan Pal Yadav & Vivek Dewan

  2. Department of Radiodiagnosis, Post Graduate Institute of Medical Education and Research and Dr. Ram Manohar Lohia Hospital, New Delhi, India

    Namrita Sachdev

Authors
  1. Tapas Baikar
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  2. Amieleena Chhabra
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  3. Tribhuvan Pal Yadav
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  4. Namrita Sachdev
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  5. Vivek Dewan
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Contributions

TB collected the data, analysed and wrote the manuscript. He shall be the first author. He also underwent training in ultrasonography in muskuloskeletal disorders (MSK) for 3 weeks and then did USG under supervision and later took part in reliability study; AC provided intellectual contribution towards manuscript writing; TPV conceptualised the study and contributed to analysis and drafting the manuscript and giving the final shape. He shall act as guarantor of the paper; NS collected the data, analysed and edited the manuscript; VD contributed to manuscript writing and editing.

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Correspondence to Tribhuvan Pal Yadav.

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Baikar, T., Chhabra, A., Yadav, T.P. et al. Power Color Doppler and Spectral Doppler Ultrasonography to Evaluate Response to Intra-articular Steroid Injection in Knee Joints in Juvenile Idiopathic Arthritis. Indian J Pediatr 84, 826–832 (2017). https://doi.org/10.1007/s12098-017-2418-x

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  • DOI: https://doi.org/10.1007/s12098-017-2418-x

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