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Long-Term Neurodevelopmental and Growth Outcomes of Premature Infants Born at <29 week Gestational Age with Post-Hemorrhagic Hydrocephalus Treated with Ventriculo-Peritoneal Shunt

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Abstract

Objective

To compare long-term neurodevelopmental and growth (NDG) outcomes at 3 y corrected gestational age (GA) in premature infants with grade ≥ III intraventricular hemorrhage (IVH) and post-hemorrhagic hydrocephalus who were treated with ventriculo-peritoneal shunt with those who were not treated with shunt.

Methods

In a retrospective cohort study, NDG outcomes were compared between preterm infants of <29 wk GA with IVH treated with shunt (IVHS) and IVH with no shunt (IVHNS). This was a single centre study. The primary outcome was moderate to severe cerebral palsy (CP).

Results

Of 1762 preterm infants who survived to discharge, 90 had grade ≥ III IVH. Infants in IVHS group had more grade IV IVH than IVHNS (p < 0.05). Seventy percent of the patients in IVHNS groups had no hydrocephalus. IVHS group had increased CP (76% vs. 30%; p 0.003), and higher odds of CP after controlling for GA and IVH grade [odds ratio (OR); 4.23 (1.38 to 13.00)]. Growth delay was not different between groups.

Conclusions

Infants with IVHS are at increased risk of CP but not growth delay.

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Acknowledgements

The authors thank Ms. Michelle Mathews for abstraction of data and entry into the database. The authors also thank Swasti Lodha and Ajay Sahai for their editorial comments.

Contributions

All authors contributed to study design, data acquisition and writing the manuscript. AL will act as guarantor for the paper.

Author information

Authors and Affiliations

  1. Section of Neonatology, Department of Pediatrics, University of Calgary, Calgary, Alberta, Canada

    K. Diwakar, A. Soraisham, Harish Amin, Majeeda Kamaluddeen & Abhay Lodha

  2. Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada

    Walter J. Hader, A. Soraisham & Abhay Lodha

  3. Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada

    Walter J. Hader, A. Soraisham, Harish Amin, Kelly Bullivant, Majeeda Kamaluddeen & Abhay Lodha

  4. Section of Pediatric Neurosurgery, Department of Surgery, University of Calgary, Calgary, Alberta, Canada

    Walter J. Hader

  5. Alberta Health Services, Calgary, Alberta, Canada

    Walter J. Hader, A. Soraisham, Harish Amin, Selphee Tang, Kelly Bullivant, Majeeda Kamaluddeen & Abhay Lodha

  6. Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada

    Abhay Lodha

  7. Department of Pediatrics, Cumming School of Medicine, Foothills Medical Centre, C211-1403 29 St NW, Calgary, AB,, T2N2T9, Canada

    Abhay Lodha

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  1. K. Diwakar
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Correspondence to Abhay Lodha.

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Diwakar, K., Hader, W.J., Soraisham, A. et al. Long-Term Neurodevelopmental and Growth Outcomes of Premature Infants Born at <29 week Gestational Age with Post-Hemorrhagic Hydrocephalus Treated with Ventriculo-Peritoneal Shunt. Indian J Pediatr 84, 662–669 (2017). https://doi.org/10.1007/s12098-017-2319-z

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  • DOI: https://doi.org/10.1007/s12098-017-2319-z

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