Abstract
Objectives
To study the correlation of obesity with various metabolic parameters and correlation between insulin resistance and leptin and retinol binding protein 4 (RBP4) levels.
Methods
This is a cross sectional study in a tertiary care children’s hospital wherein 98 obese children were included and their metabolic parameters analysed with regards to insulin resistance and RBP4 levels.
Results
Leptin levels were abnormal for all children and high RBP4 levels were observed in 69.6 %. There was no significant association between insulin resistance and RBP4 levels (p 0.8).
Conclusions
RBP4, the sole retinol transporter in blood, secreted from adipocytes and liver has been implicated in insulin resistance. The index study however, did not show a significant positive association.
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Acknowledgments
The authors acknowledge all the patients and their parents who have consented to be part of the research.
Contributions
VT: Formulated the study and oversaw the study from inception to completion of the manuscript; SA: Prepared the manuscript and did the literature search; RU: Done the data collection and statistical work co-ordination with the statistician; RPB: Has been instrumental in the laboratory work up in the research. VT will act as guarantor for this paper.
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Thiruvengadam, V., Amperayani, S., Babu, R.P. et al. Correlation of Childhood Obesity and Related Insulin Resistance with Leptin and Retinol Binding Protein 4. Indian J Pediatr 82, 799–804 (2015). https://doi.org/10.1007/s12098-015-1706-6
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DOI: https://doi.org/10.1007/s12098-015-1706-6