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SBRT-SG-01: final results of a prospective multicenter study on stereotactic body radiotherapy for liver metastases

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Abstract

Objective

This study aimed to assess the efficacy and tolerability of stereotactic body radiation therapy (SBRT) for the treatment of liver metastases.

Methods

Patients with up to 5 liver metastases were enrolled in this prospective multicenter study and underwent SBRT. Efficacy outcomes included in-field local control (LC), progression-free survival (PFS), and overall survival (OS). Acute and late toxicities were evaluated using CTCAE v.4.0.

Results

A total of 52 patients with 105 liver metastases were treated between 2015 and 2018. The most common primary tumor was colorectal cancer (72% of cases). Liver metastases were synchronous with the primary tumor diagnosis in 24 patients (46.2%), and 21 patients (40.4%) presented with other extrahepatic oligometastases. All patients underwent intensity-modulated radiation therapy (IMRT)/volumetric-modulated arc therapy (VMAT) with image-guided radiation therapy (IGRT) and respiratory gating, and a minimum biologically effective dose (BED10Gy) of 100 Gy was delivered to all lesions. With a median follow-up of 23.1 months (range: 13.4–30.9 months) since liver SBRT, the median actuarial local progression-free survival (local-PFS) was not reached. The actuarial in-field LC rates were 84.9% and 78.4% at 24 and 48 months, respectively. The median actuarial liver-PFS and distant-PFS were 11 and 10.8 months, respectively. The actuarial median overall survival (OS) was 27.7 months from SBRT and 52.5 months from metastases diagnosis. Patients with lesion diameter ≤ 5 cm had significantly better median liver-PFS (p = 0.006) and OS (p = 0.018). No acute or late toxicities of grade ≥ 3 were observed.

Conclusions

This prospective multicenter study confirms that liver SBRT is an effective alternative for the treatment of liver metastases, demonstrating high rates of local control and survival while maintaining a low toxicity profile.

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Data availability

Data are available at rationale request.

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Funding

The authors declare no funding or research grants received in the course of study, research or assembly of the manuscript.

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Authors and Affiliations

  1. Radiation Oncology, Hospital Universitario HM Sanchinarro, HM Hospitales, Madrid, Spain

    María-Carmen Rubio Rodríguez, Ovidio Hernando, Mercedes López, Emilio Sánchez-Saugar, Jeannette Valero, Angel Montero, Raquel Ciérvide, Beatriz Alvarez, Mariola García-Aranda & Mónica Nuñez

  2. Radiation Oncology, Complejo Hospitalario de Navarra, Navarra, Spain

    Sonia Flamarique, Maider Campo, Maitane Rodríguez & Fernando Arias

  3. Radiation Oncology, Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain

    Xin Chen-Zhao & Rosa Alonso

  4. Medical Physics, Hospital Universitario HM Sanchinarro, HM Hospitales, Madrid, Spain

    Pedro Fernández-Letón, Daniel Zucca, Miguel Angel de la Casa, Leyre Alonso & Jaime Martí

  5. Medical Physics, Complejo Hospitalario de Navarra, Navarra, Spain

    Daniel Martínez & Fernando Mañeru

  6. Medical Physics, Hospital Universitario HM Puerta del Sur, HM Hospitales, Madrid, Spain

    Juan García Ruiz-Zorrilla & Paz García de Acilu

Authors
  1. María-Carmen Rubio Rodríguez
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  2. Xin Chen-Zhao
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  15. Jeannette Valero
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Corresponding author

Correspondence to María-Carmen Rubio Rodríguez.

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Conflict of interest

The autors declare that there’s no financial/personal interest or belief that could affect their objectivity, or if there is, stating the source and nature of that potential conflict.

Ethical approval

This study is a prospective, multicenter non-randomized clinical trial approved by the Institutional Review Boards of the Ethics Committees at the Fundación HM Hospitales (15.04.781-GHM) and Hospital Universitario de Navarra (Pyto2015/99). The study was conducted in accordance with the ethical standards outlined in the 1964 Declaration of Helsinki.

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Informed consent was obtained from all participating subjects before inclusion.

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Rodríguez, MC.R., Chen-Zhao, X., Hernando, O. et al. SBRT-SG-01: final results of a prospective multicenter study on stereotactic body radiotherapy for liver metastases. Clin Transl Oncol (2024). https://doi.org/10.1007/s12094-024-03403-w

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  • DOI: https://doi.org/10.1007/s12094-024-03403-w

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