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Emerging roles of long non-coding RNA FTX in human disorders

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Abstract

Long non-coding RNAs (lncRNAs) are involved the progression of cancerous and non-cancerous disorders via different mechanism. FTX (five prime to xist) is an evolutionarily conserved lncRNA that is located upstream of XIST and regulates its expression. FTX participates in progression of various malignancy including gastric cancer, glioma, ovarian cancer, pancreatic cancer, and retinoblastoma. Also, FTX can be involved in the pathogenesis of non-cancerous disorders such as endometriosis and stroke. FTX acts as competitive endogenous RNA (ceRNA) and via sponging various miRNAs, including miR-186, miR-200a-3p, miR-215-3p, and miR-153-3p to regulate the expression of their downstream target. FTX by targeting various signaling pathways including Wnt/β-catenin, PI3K/Akt, SOX4, PDK1/PKB/GSK-3β, TGF-β1, FOXA2, and PPARγ regulate molecular mechanism involved in various disorders. Dysregulation of FTX is associated with an increased risk of various disorders. Therefore, FTX and its downstream targets may be suitable biomarkers for the diagnosis and treatment of human malignancies. In this review, we summarized the emerging roles of FTX in human cancerous and non-cancerous cells.

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Data availability

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Authors and Affiliations

  1. Department of Laboratory, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

    Mohadeseh Sheykhi-Sabzehpoush

  2. Department of Clinical Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Majid Ghasemian

  3. Department of Obstetrics and Gynecology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

    Fatemeh Khojasteh Pour

  4. School of Medicine, Golestan University of Medical Sciences, Golestan, Iran

    Mohammad Mighani

  5. Department of Genetics, Faculty of Medicine, Kazerun Branch, Islamic Azad University, Kazerun, Iran

    Mehdi Moghanibashi

  6. Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Razieh Mohammad Jafari & Maryam Farzaneh

  7. Division of Anatomy and Histology, University of Zielona Góra, 65-046, Zielona Góra, Poland

    Maciej Zabel

  8. Division of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368, Wroclaw, Poland

    Maciej Zabel & Piotr Dzięgiel

  9. Department of Human Morphology and Embryology, Division of Anatomy, Wroclaw Medical, University, Wrocław, Poland

    Bartosz Kempisty

  10. Institute of Veterinary Medicine, Department of Veterinary Surgery, Nicolaus Copernicus University, Torun, Poland

    Bartosz Kempisty

  11. North Carolina State University College of Agriculture and Life Sciences, Raleigh, NC, 27695, USA

    Bartosz Kempisty

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  1. Mohadeseh Sheykhi-Sabzehpoush
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Sheykhi-Sabzehpoush, M., Ghasemian, M., Khojasteh Pour, F. et al. Emerging roles of long non-coding RNA FTX in human disorders. Clin Transl Oncol 25, 2812–2831 (2023). https://doi.org/10.1007/s12094-023-03163-z

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