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CircRNAs: emerging factors for regulating glucose metabolism in colorectal cancer

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Abstract

Colorectal cancer is a malignant disease with a high incidence and low survival rate, and the effectiveness of traditional treatments, such as surgery and radiotherapy, is very limited. CircRNAs, a kind of stable endogenous circular RNA, generally function by sponging miRNAs and binding or translating proteins. CircRNAs have been identified to play an important role in regulating the proliferation and metabolism of CRC. In recent years, many reports have indicated that by regulating the expression of glycolysis-related proteins, such as GLUT1 and HK2, or directly translating proteins, circRNAs can promote the Warburg effect in cancer cells, thereby driving CRC metabolism. Moreover, the Warburg effect increases lactate production in cancer cells and promotes acidification of the TME, which further drives cancer progression. In this review, we summarized the remarkable role of circRNAs in regulating glucose metabolism in CRC in recent years, which might be useful for finding new targets for the clinical treatment of CRC.

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Funding

This work was supported by the Cuiying Scientific Training Program for Undergraduates of Lanzhou University Second Hospital (CYXZ2022-47); Lanzhou University 2022 College Students Innovation and Entrepreneurship [20220060024; 20220060112; 20220060053]; National Natural Science Foundation of China, 82060800; Gansu Province Youth Science and Technology Fund program, 20JR10RA759; Health industry science and technology plan of Gansu Province, GSWSKY2020-30.

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  1. Yulin Liu and Chenjun Jiang have contributed equally to this work.

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  1. The Second Clinical Medical College, Lanzhou University, Lanzhou, 730000, The People’s Republic of China

    Yulin Liu, Mancai Wang & Xiaohu Guo

  2. The First Clinical Medical College, Lanzhou University, Lanzhou, 730000, The People’s Republic of China

    Chenjun Jiang, Qianqian Liu & Runchun Huang

  3. General Surgery Department, The Second Hospital of Lanzhou University, Lanzhou, 730000, China

    Mancai Wang & Xiaohu Guo

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YL and CJ contributed to the conception and design of the manuscript. QL, RH, and MW outlined and revised the manuscript. XG analyzed and finalized the figures and table. All authors have read the manuscript and approved to the submitted version.

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Liu, Y., Jiang, C., Liu, Q. et al. CircRNAs: emerging factors for regulating glucose metabolism in colorectal cancer. Clin Transl Oncol 25, 2321–2331 (2023). https://doi.org/10.1007/s12094-023-03131-7

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