Skip to main content

Advertisement

SpringerLink
Log in

Potential roles of lncRNA-XIST/miRNAs/mRNAs in human cancer cells

  • REVIEW ARTICLE
  • Published:
Clinical and Translational Oncology Aims and scope Submit manuscript

Abstract

Long non-coding RNAs (lncRNAs) are non-coding RNAs that contain more than 200 nucleotides but do not code for proteins. In tumorigenesis, lncRNAs can have both oncogenic and tumor-suppressive properties. X inactive-specific transcript (XIST) is a known lncRNA that has been implicated in X chromosome silencing in female cells. Dysregulation of XIST is associated with an increased risk of various cancers. Therefore, XIST can be a beneficial prognostic biomarker for human malignancies. In this review, we attempt to summarize the emerging roles of XIST in human cancers.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request.

References

  1. Wang W, Min L, Qiu X, Wu X, Liu C, Ma J, et al. Biological Function of Long Non-coding RNA (LncRNA) Xist. Front Cell Dev Biol. 2021;9:645647–645647.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Azizidoost S, Nasrolahi A, Ghaedrahmati F, Kempisty B, Mozdziak P, Radoszkiewicz K, et al. The pathogenic roles of lncRNA-Taurine upregulated 1 (TUG1) in colorectal cancer. Cancer Cell Int. 2022;22:1–8.

    Article  Google Scholar 

  3. Derrien T, Johnson R, Bussotti G, Tanzer A, Djebali S, Tilgner H, et al. The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome Res. 2012;22:1775–89.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Farzaneh M, Najafi S, Sheykhi-Sabzehpoush M, Nezhad Dehbashi F, Anbiyaee O, Nasrolahi A, et al. The stem cell-specific long non-coding RNAs in leukemia. Clin Transl Oncol. 2022. https://doi.org/10.1007/s12094-022-02952-2.

    Article  PubMed  Google Scholar 

  5. Cao H, Wahlestedt C, Kapranov P. Strategies to annotate and characterize long noncoding RNAs: advantages and pitfalls. Trends Genet. 2018;34:704–21.

    Article  CAS  PubMed  Google Scholar 

  6. Xu W-W, Jin J. Wu X-y, Ren Q-L, Farzaneh M: MALAT1-related signaling pathways in colorectal cancer. Cancer Cell Int. 2022;22:1–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Anbiyaiee A, Ramazii M, Bajestani SS, Meybodi SM, Keivan M, Khoshnam SE, et al. The function of LncRNA-ATB in cancer. Clin Transl Oncol. 2022;25:1–9.

    Article  PubMed  Google Scholar 

  8. Brockdorff N. Localized accumulation of Xist RNA in X chromosome inactivation. Open Biol. 2019;9: 190213.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Patrat C, Ouimette J-F, Rougeulle C. X chromosome inactivation in human development. Development. 2020. https://doi.org/10.1242/dev.183095.

    Article  PubMed  Google Scholar 

  10. Wang D, Tang L, Wu Y, Fan C, Zhang S, Xiang B, et al. Abnormal X chromosome inactivation and tumor development. Cell Mol Life Sci. 2020;77:2949–58.

    Article  CAS  PubMed  Google Scholar 

  11. Chaligné R, Heard E. X-chromosome inactivation in development and cancer. FEBS Lett. 2014;588:2514–22.

    Article  PubMed  Google Scholar 

  12. Dinescu S, Ignat S, Lazar AD, Constantin C, Neagu M, Costache M. Epitranscriptomic signatures in lncRNAs and their possible roles in cancer. Genes. 2019;10:52.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Eldesouki S, Samara KA, Qadri R, Obaideen AA, Otour AH, Habbal O, et al. XIST in brain cancer. Clin Chim Acta. 2022. https://doi.org/10.1016/j.cca.2022.04.993.

    Article  PubMed  Google Scholar 

  14. Liu X, Ming X, Jing W, Luo P, Li N, Zhu M, et al. Long non-coding RNA XIST predicts worse prognosis in digestive system tumors: a systemic review and meta-analysis. 2018. Biosci Rep. https://doi.org/10.1042/BSR20180169.

  15. Deng C, Hu X, Wu K, Tan J, Yang C. Long non-coding RNA XIST predicting advanced clinical parameters in cancer: A Meta-Analysis and case series study in a single institution. Oncol Lett. 2019;18:2192–202.

    CAS  PubMed  PubMed Central  Google Scholar 

  16. Xing F, Liu Y, Wu S-Y, Wu K, Sharma S, Mo Y-Y, et al. Loss of XIST in breast cancer activates MSN-c-met and reprograms microglia via exosomal miRNA to promote brain metastasisLoss of XIST promotes brain metastasis. Can Res. 2018;78:4316–30.

    Article  CAS  Google Scholar 

  17. Jung J, Seol HS, Chang S. The generation and application of patient-derived xenograft model for cancer research. Cancer Res Treat. 2017;50:1–10.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Liu A, Liu L, Lu H. LncRNA XIST facilitates proliferation and epithelial–mesenchymal transition of colorectal cancer cells through targeting miR-486-5p and promoting neuropilin-2. J Cell Physiol. 2019;234:13747–61.

    Article  CAS  PubMed  Google Scholar 

  19. Song H, He P, Shao T, Li Y, Li J, Zhang Y. Long non-coding RNA XIST functions as an oncogene in human colorectal cancer by targeting miR-132-3p. J buon. 2017;22:696–703.

    PubMed  Google Scholar 

  20. Chen D-l, Chen L-z, Lu Y-x, Zhang D-s, Zeng Z-l, Pan Z-z, et al. Long noncoding RNA XIST expedites metastasis and modulates epithelial–mesenchymal transition in colorectal cancer. Cell Death Dis. 2017;8:e3011–e3011.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Yan Z, Li J, Guo J, He R, Xing J. LncRNA XIST sponges microRNA-448 to promote malignant behaviors of colorectal cancer cells via regulating GRHL2. Funct Integr Genom. 2022. https://doi.org/10.1007/s10142-022-00873-5.

    Article  Google Scholar 

  22. Sun N, Zhang G, Liu Y. Long non-coding RNA XIST sponges miR-34a to promotes colon cancer progression via Wnt/β-catenin signaling pathway. Gene. 2018;665:141–8.

    Article  CAS  PubMed  Google Scholar 

  23. Lg Y, Mz C. Zhang J, Li Xy, Sun Ql: LncRNA XIST modulates HIF-1A/AXL signaling pathway by inhibiting miR-93-5p in colorectal cancer. Mol Genet Genom Med. 2020;8: e1112.

    Google Scholar 

  24. Zhang R, Wang Z, Yu Q, Shen J, He W, Zhou D, et al. Atractylenolide II reverses the influence of lncRNA XIST/miR-30a-5p/ROR1 axis on chemo-resistance of colorectal cancer cells. J Cell Mol Med. 2019;23:3151–65.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Zheng H, Zhang M, Ke X, Deng X, Li D, Wang Q, et al. LncRNA XIST/miR-137 axis strengthens chemo-resistance and glycolysis of colorectal cancer cells by hindering transformation from PKM2 to PKM1. Cancer Biomark. 2021;30:395–406.

    Article  CAS  PubMed  Google Scholar 

  26. Zeng Zl LuJh, Wang Y, Sheng H, Yn W, Chen Zh, et al. The lncRNA XIST/miR-125b-2-3p axis modulates cell proliferation and chemotherapeutic sensitivity via targeting Wee1 in colorectal cancer. Cancer Med. 2021;10:2423–41.

    Article  PubMed  Google Scholar 

  27. Xiao Y, Yurievich UA, Yosypovych SV. Long noncoding RNA XIST is a prognostic factor in colorectal cancer and inhibits 5-fluorouracil-induced cell cytotoxicity through promoting thymidylate synthase expression. Oncotarget. 2017;8:83171.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Liu C, Lu Z, Liu H, Zhuang S, Guo P. LncRNA XIST promotes the progression of laryngeal squamous cell carcinoma via sponging miR-125b-5p to modulate TRIB2. 2020. Biosci Rep. https://doi.org/10.1042/BSR20193172.

  29. Xiao D, Cui X, Wang X. Long noncoding RNA XIST increases the aggressiveness of laryngeal squamous cell carcinoma by regulating miR-124-3p/EZH2. Exp Cell Res. 2019;381:172–8.

    Article  CAS  PubMed  Google Scholar 

  30. Yao L, Yang L, Song H, Liu T, Yan H. Silencing of lncRNA XIST suppresses proliferation and autophagy and enhances vincristine sensitivity in retinoblastoma cells by sponging miR-204-5p. Eur Rev Med Pharmacol Sci. 2020;24:3526–37.

    CAS  PubMed  Google Scholar 

  31. Kou J, Ma J, Zhu J, Xu W, Liu Z, Zhang X, et al. LncRNA NEAT1 regulates proliferation, apoptosis and invasion of liver cancer. Eur Rev Med Pharmacol Sci. 2020;24:4152–60.

    PubMed  Google Scholar 

  32. Cheng Y, Chang Q, Zheng B, Xu J, Li H, Wang R. LncRNA XIST promotes the epithelial to mesenchymal transition of retinoblastoma via sponging miR-101. Eur J Pharmacol. 2019;843:210–6.

    Article  CAS  PubMed  Google Scholar 

  33. Zhao H, Wan J, Zhu Y. Carboplatin inhibits the progression of retinoblastoma through IncRNA XIST/miR-200a-3p/NRP1 Axis. Drug Des Dev Ther. 2020;14:3417.

    Article  CAS  Google Scholar 

  34. Yang L, Li Q, Zhang X, Cao T. Long non-coding RNA XIST confers aggressive progression via miR-361-3p/STX17 in retinoblastoma cells. Eur Rev Med Pharmacol Sci. 2020;24:10433–44.

    PubMed  Google Scholar 

  35. Xu Y, Fu Z, Gao X, Wang R, Li Q. Long non-coding RNA XIST promotes retinoblastoma cell proliferation, migration, and invasion by modulating microRNA-191-5p/brain derived neurotrophic factor. Bioengineered. 2021;12:1587–98.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Wang Y, Sun D, Sheng Y, Guo H, Meng F, Song T. XIST promotes cell proliferation and invasion by regulating miR-140-5p and SOX4 in retinoblastoma. World J SurgOncol. 2020;18:1–8.

    Google Scholar 

  37. Tan W, Yuan Y, Huang H, Ma J, Li Y, Gou Y, et al. Comprehensive analysis of autophagy related long non-coding RNAs in prognosis, immunity, and treatment of muscular invasive bladder cancer. Sci Rep. 2022;12:1–13.

    Article  CAS  Google Scholar 

  38. Li H-J, Gong X, Li Z-K, Qin W, He C-X, Xing L, et al. Role of long non-coding RNAs on bladder cancer. Front Cell Dev Biol. 2021;9: 672679.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Xu R, Zhu X, Chen F, Huang C, Ai K, Wu H, et al. LncRNA XIST/miR-200c regulates the stemness properties and tumourigenicity of human bladder cancer stem cell-like cells. Cancer Cell Int. 2018;18:41.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Zhou K, Yang J, Li X, Chen W. Long non-coding RNA XIST promotes cell proliferation and migration through targeting miR-133a in bladder cancer. Exp Ther Med. 2019;18:3475–83.

    CAS  PubMed  PubMed Central  Google Scholar 

  41. Xiong Y, Wang L, Li Y, Chen M, He W, Qi L. The Long Non-Coding RNA XIST Interacted with MiR-124 to Modulate Bladder Cancer Growth, Invasion and Migration by Targeting Androgen Receptor (AR). Cell Physiol Biochem. 2017;43:405–18.

    Article  CAS  PubMed  Google Scholar 

  42. Hu B, Shi G, Li Q, Li W, Zhou H. Long noncoding RNA XIST participates in bladder cancer by downregulating p53 via binding to TET1. J Cell Biochem. 2019;120:6330–8.

    Article  CAS  PubMed  Google Scholar 

  43. Hu Y, Deng C, Zhang H, Zhang J, Peng B, Hu C. Long non-coding RNA XIST promotes cell growth and metastasis through regulating miR-139-5p mediated Wnt/β-catenin signaling pathway in bladder cancer. Oncotarget. 2017;8:94554–68.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Chen D, Chen T, Guo Y, Wang C, Dong L, Lu C. Platycodin D (PD) regulates LncRNA-XIST/miR-335 axis to slow down bladder cancer progression in vitro and in vivo. Exp Cell Res. 2020;396: 112281.

    Article  CAS  PubMed  Google Scholar 

  45. Zhu H, Zheng T, Yu J, Zhou L, Wang L. LncRNA XIST accelerates cervical cancer progression via upregulating Fus through competitively binding with miR-200a. Biomed Pharmacother. 2018;105:789–97.

    Article  CAS  PubMed  Google Scholar 

  46. Liu X, Xie S, Zhang J, Kang Y. Long noncoding RNA XIST contributes to cervical cancer development through targeting miR-889-3p/SIX1 Axis. Cancer Biother Radiopharm. 2020;35:640–9.

    CAS  PubMed  Google Scholar 

  47. Chen X, Xiong D, Ye L, Wang K, Huang L, Mei S, et al. Up-regulated lncRNA XIST contributes to progression of cervical cancer via regulating miR-140-5p and ORC1. Cancer Cell Int. 2019;19:45.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Lee S-H, Kim SW, Nam EJ, Park JS, Kim JW, Kim YT. The functional role and clinical significance of long non-coding RNA Xist in cervical cancer. Gynecol Oncol. 2019;154:84.

    Article  Google Scholar 

  49. Guo T, Yuan D, Zhang W, Zhu D, Xiao A, Mao G, et al. Upregulation of long noncoding RNA XIST has anticancer effects on ovarian cancer through sponging miR-106a. Hum Cell. 2021;34:579–87.

    Article  CAS  PubMed  Google Scholar 

  50. Zuo K, Zhao Y, Zheng Y, Chen LX, Du S, et al. Long non-coding RNA XIST promotes malignant behavior of epithelial ovarian cancer. Onco Targets Ther. 2019;12:7261–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Meng Q, Wang N, Duan G. Long non-coding RNA XIST regulates ovarian cancer progression via modulating miR-335/BCL2L2 axis. World J Surg Oncol. 2021;19:165.

    Article  PubMed  PubMed Central  Google Scholar 

  52. Wang C, Qi S, Xie C, Li C, Wang P, Liu D. Upregulation of long non-coding RNA XIST has anticancer effects on epithelial ovarian cancer cells through inverse downregulation of hsa-miR-214-3p. J Gynecol Oncol. 2018;29: e99.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Jiang R, Zhang H, Zhou J, Wang J, Xu Y, Zhang H, et al. Inhibition of long non-coding RNA XIST upregulates microRNA-149-3p to repress ovarian cancer cell progression. Cell Death Dis. 2021;12:145.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Huang R, Zhu L, Zhang Y. XIST lost induces ovarian cancer stem cells to acquire taxol resistance via a KMT2C-dependent way. Cancer Cell Int. 2020;20:436.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Zhao L, Zhao Y, He Y, Li Q, Mao Y. The functional pathway analysis and clinical significance of miR-20a and its related lncRNAs in breast cancer. Cell Sig. 2018;51:152–65.

    Article  CAS  Google Scholar 

  56. Zheng R, Lin S, Guan L, Yuan H, Liu K, Liu C, et al. Long non-coding RNA XIST inhibited breast cancer cell growth, migration, and invasion via miR-155/CDX1 axis. Biochem Biophys Res Commun. 2018;498:1002–8.

    Article  CAS  PubMed  Google Scholar 

  57. Zong Y, Zhang Y, Hou D, Xu J, Cui F, Qin Y, et al. The lncRNA XIST promotes the progression of breast cancer by sponging miR-125b-5p to modulate NLRC5. Am J Trans Res. 2020;12:3501.

    CAS  Google Scholar 

  58. Huang Y-S, Chang C-C, Lee S-S, Jou Y-S, Shih H-M. Xist reduction in breast cancer upregulates AKT phosphorylation via HDAC3-mediated repression of PHLPP1 expression. Oncotarget. 2016;7:43256.

    Article  PubMed  PubMed Central  Google Scholar 

  59. Zhang M, Wang F, Xiang Z, Huang T, Zhou WB. LncRNA XIST promotes chemoresistance of breast cancer cells to doxorubicin by sponging miR-200c-3p to upregulate ANLN. Clin Exp Pharmacol Physiol. 2020;47:1464–72.

    Article  CAS  PubMed  Google Scholar 

  60. Liu B, Luo C, Lin H, Ji X, Zhang E, Li X. Long Noncoding RNA XIST Acts as a ceRNA of miR-362-5p to Suppress Breast Cancer Progression. Cancer Biother Radiopharm. 2021;36:456–66.

    CAS  PubMed  Google Scholar 

  61. Samir A, Tawab RA, El Tayebi HM. Long non-coding RNAs XIST and MALAT1 hijack the PD-L1 regulatory signaling pathway in breast cancer subtypes. Oncol Lett. 2021;22:593.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  62. Hamed MM, Handoussa H, Hussein NH, Eissa RA, Abdel-Aal LK, El Tayebi HM. Oleuropin controls miR-194/XIST/PD-L1 loop in triple negative breast cancer: New role of nutri-epigenetics in immune-oncology. Life Sci. 2021;277: 119353.

    Article  CAS  PubMed  Google Scholar 

  63. Swellam M, El Magdoub HM, Shawki MA, Adel M, Hefny MM, El-Shazly SS. Clinical impact of LncRNA XIST and LncRNA NEAT1 for diagnosis of high-risk group breast cancer patients. Curr Probl Cancer. 2021;45: 100709.

    Article  PubMed  Google Scholar 

  64. Lan F, Zhang X, Li H, Yue X, Sun Q. Serum exosomal lncRNA XIST is a potential non-invasive biomarker to diagnose recurrence of triple-negative breast cancer. J Cell Mol Med. 2021;25:7602–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  65. Liu J, Yao L, Zhang M, Jiang J, Yang M, Wang Y. Downregulation of LncRNA-XIST inhibited development of non-small cell lung cancer by activating miR-335/SOD2/ROS signal pathway mediated pyroptotic cell death. Aging (Albany NY). 2019;11:7830–46.

    Article  CAS  PubMed  Google Scholar 

  66. Zhou X, Xu X, Gao C, Cui Y. XIST promote the proliferation and migration of non-small cell lung cancer cells via sponging miR-16 and regulating CDK8 expression. Am J Transl Res. 2019;11:6196–206.

    CAS  PubMed  PubMed Central  Google Scholar 

  67. Qiu HB, Yang K, Yu HY, Liu M. Downregulation of long non-coding RNA XIST inhibits cell proliferation, migration, invasion and EMT by regulating miR-212-3p/CBLL1 axis in non-small cell lung cancer cells. Eur Rev Med Pharmacol Sci. 2019;23:8391–402.

    PubMed  Google Scholar 

  68. Jiang H, Zhang H, Hu X, Li W. Knockdown of long non-coding RNA XIST inhibits cell viability and invasion by regulating miR-137/PXN axis in non-small cell lung cancer. Int J Biol Macromol. 2018;111:623–31.

    Article  CAS  PubMed  Google Scholar 

  69. Wang H, Shen Q, Zhang X, Yang C, Cui S, Sun Y, et al. The long non-coding RNA XIST controls non-small cell lung cancer proliferation and invasion by modulating miR-186-5p. Cell Physiol Biochem. 2017;41:2221–9.

    Article  CAS  PubMed  Google Scholar 

  70. Li J, Che L, Xu C, Lu D, Xu Y, Liu M, et al. XIST/miR-34a-5p/PDL1 axis regulated the development of lung cancer cells and the immune function of CD8(+) T cells. J Recept Sig Transt Res. 2022. https://doi.org/10.1080/10799893.2021.2019274.

    Article  Google Scholar 

  71. Zhang YL, Li XB, Hou YX, Fang NZ, You JC, Zhou QH. The lncRNA XIST exhibits oncogenic properties via regulation of miR-449a and Bcl-2 in human non-small cell lung cancer. Acta Pharmacol Sin. 2017;38:371–81.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  72. Tang Y, He R, An J, Deng P, Huang L, Yang W. lncRNA XIST interacts with miR-140 to modulate lung cancer growth by targeting iASPP. Oncol Rep. 2017;38:941–8.

    Article  CAS  PubMed  Google Scholar 

  73. Jiang Q, Xing W, Cheng J, Yu Y. Knockdown of lncRNA XIST Suppresses Cell Tumorigenicity in Human Non-Small Cell Lung Cancer by Regulating miR-142-5p/PAX6 Axis. Onco Target Ther. 2020;13:4919–29.

    Article  CAS  Google Scholar 

  74. Rong H, Chen B, Wei X, Peng J, Ma K, Duan S, et al. Long non-coding RNA XIST expedites lung adenocarcinoma progression through upregulating MDM2 expression via binding to miR-363-3p. Thorac Cancer. 2020;11:659–71.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  75. Wang J, Cai H, Dai Z, Wang G. Down-regulation of lncRNA XIST inhibits cell proliferation via regulating miR-744/RING1 axis in non-small cell lung cancer. Clin Sci (Lond). 2019;133:1567–79.

    Article  CAS  PubMed  Google Scholar 

  76. Li C, Wan L, Liu Z, Xu G, Wang S, Su Z, et al. Long non-coding RNA XIST promotes TGF-β-induced epithelial-mesenchymal transition by regulating miR-367/141-ZEB2 axis in non-small-cell lung cancer. Cancer Lett. 2018;418:185–95.

    Article  CAS  PubMed  Google Scholar 

  77. Wang X, Zhang G, Cheng Z, Dai L, Jia L, Jing X, et al. Knockdown of LncRNA-XIST Suppresses Proliferation and TGF-β1-Induced EMT in NSCLC Through the Notch-1 Pathway by Regulation of miR-137. Genet Test Mol Biomark. 2018;22:333–42.

    Article  CAS  Google Scholar 

  78. Fang J, Sun C-C, Gong C. Long noncoding RNA XIST acts as an oncogene in non-small cell lung cancer by epigenetically repressing KLF2 expression. Biochem Biophys Res Commun. 2016;478:811–7.

    Article  CAS  PubMed  Google Scholar 

  79. Du R, Jiang F, Yin Y, Xu J, Li X, Hu L, et al. Knockdown of lncRNA X inactive specific transcript (XIST) radiosensitizes non-small cell lung cancer (NSCLC) cells through regulation of miR-16-5p/WEE1 G2 checkpoint kinase (WEE1) axis. Int J Immunopathol Pharmacol. 2021;35:2058738420966087.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  80. Xu X, Zhou X, Chen Z, Gao C, Zhao L, Cui Y. Silencing of lncRNA XIST inhibits non-small cell lung cancer growth and promotes chemosensitivity to cisplatin. Aging (Albany NY). 2020;12:4711–26.

    Article  CAS  PubMed  Google Scholar 

  81. Hua G, Zeng ZL, Shi YT, Chen W, He LF, Zhao GF. LncRNA XIST contributes to cisplatin resistance of lung cancer cells by promoting cellular glycolysis through sponging miR-101-3p. Pharmacology. 2021;106:498–508.

    Article  CAS  PubMed  Google Scholar 

  82. Sun J, Pan LM, Chen LB, Wang Y. LncRNA XIST promotes human lung adenocarcinoma cells to cisplatin resistance via let-7i/BAG-1 axis. Cell Cycle. 2017;16:2100–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  83. Tian LJ, Wu YP, Wang D, Zhou ZH, Xue SB, Zhang DY, et al. Upregulation of long noncoding RNA (lncRNA) X-inactive specific transcript (XIST) is associated with cisplatin resistance in non-small cell lung cancer (NSCLC) by downregulating MicroRNA-144-3p. Med Sci Monit. 2019;25:8095–104.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  84. Liu TT, Li R, Liu X, Zhou XJ, Huo C, Li JP, et al. LncRNA XIST acts as a MicroRNA-520 sponge to regulate the Cisplatin resistance in NSCLC cells by mediating BAX through CeRNA network. Int J Med Sci. 2021;18:419–31.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  85. Sun W, Zu Y, Fu X, Deng Y. Knockdown of lncRNA-XIST enhances the chemosensitivity of NSCLC cells via suppression of autophagy. Oncol Rep. 2017;38:3347–54.

    CAS  PubMed  PubMed Central  Google Scholar 

  86. Liu JH, Li C, Cao L, Zhang CH, Zhang ZH. Cucurbitacin B regulates lung cancer cell proliferation and apoptosis via inhibiting the IL-6/STAT3 pathway through the lncRNA XIST/miR-let-7c axis. Pharm Biol. 2022;60:154–62.

    Article  CAS  PubMed  Google Scholar 

  87. Sun L, Zhang M, Qu H. lncRNA XIST regulates cell proliferation, migration and invasion via regulating miR-30b and RECK in nasopharyngeal carcinoma. Oncol Lett. 2021;21:256.

    Article  PubMed  PubMed Central  Google Scholar 

  88. Zhao CH, Bai XF, Hu XH. Knockdown of lncRNA XIST inhibits hypoxia-induced glycolysis, migration and invasion through regulating miR-381-3p/NEK5 axis in nasopharyngeal carcinoma. Eur Rev Med Pharmacol Sci. 2020;24:2505–17.

    PubMed  Google Scholar 

  89. Cheng Q, Xu X, Jiang H, Xu L, Li Q. Knockdown of long non-coding RNA XIST suppresses nasopharyngeal carcinoma progression by activating miR-491-5p. J Cell Biochem. 2018;119:3936–44.

    Article  CAS  PubMed  Google Scholar 

  90. Shi J, Tan S, Song L, Song L, Wang Y. LncRNA XIST knockdown suppresses the malignancy of human nasopharyngeal carcinoma through XIST/miRNA-148a-3p/ADAM17 pathway in vitro and in vivo. Biomed Pharmacother. 2020;121: 109620.

    Article  CAS  PubMed  Google Scholar 

  91. Han Q, Li L, Liang H, Li Y, Xie J, Wang Z. Downregulation of lncRNA X inactive specific transcript (XIST) suppresses cell proliferation and enhances radiosensitivity by upregulating mir-29c in nasopharyngeal carcinoma cells. Med Sci Monit. 2017;23:4798–807.

    Article  PubMed  PubMed Central  Google Scholar 

  92. Song P, Ye LF, Zhang C, Peng T, Zhou XH. Long non-coding RNA XIST exerts oncogenic functions in human nasopharyngeal carcinoma by targeting miR-34a-5p. Gene. 2016;592:8–14.

    Article  CAS  PubMed  Google Scholar 

  93. Zhang Y, Xu L, Li A, Han X. The roles of ZEB1 in tumorigenic progression and epigenetic modifications. Biomed Pharmacother. 2019;110:400–8.

    Article  CAS  PubMed  Google Scholar 

  94. Drápela S, Bouchal J, Jolly MK, Culig Z, Souček K. ZEB1: a critical regulator of cell plasticity, DNA damage response, and therapy resistance. Front Mol Biosci. 2020;7:36.

    Article  PubMed  PubMed Central  Google Scholar 

  95. Zhou B, Lin W, Long Y, Yang Y, Zhang H, Wu K, et al. Notch signaling pathway: Architecture, disease, and therapeutics. Signal Trans Target Ther. 2022;7:1–33.

    CAS  Google Scholar 

  96. Liu P, Pan Y, Wang D, You D. Long non-coding RNA XIST promotes cell proliferation of pancreatic cancer through miR-137 and Notch1 pathway. Eur Rev Med Pharmacol Sci. 2020;24:12161–70.

    PubMed  Google Scholar 

  97. Shen J, Hong L, Yu D, Cao T, Zhou Z, He S. LncRNA XIST promotes pancreatic cancer migration, invasion and EMT by sponging miR-429 to modulate ZEB1 expression. Int J Biochem Cell Biol. 2019;113:17–26.

    Article  CAS  PubMed  Google Scholar 

  98. Wei W, Liu Y, Lu Y, Yang B, Tang L. LncRNA XIST promotes pancreatic cancer proliferation through miR-133a/EGFR. J Cell Biochem. 2017;118:3349–58.

    Article  CAS  PubMed  Google Scholar 

  99. Zou L, Chen F-R, Xia R-P, Wang H-W, Xie Z-R, Xu Y, et al. Long noncoding RNA XIST regulates the EGF receptor to promote TGF-β1-induced epithelial–mesenchymal transition in pancreatic cancer. Biochem Cell Biol. 2020;98:267–76.

    Article  CAS  PubMed  Google Scholar 

  100. Sun Z, Zhang B, Cui T. Long non-coding RNA XIST exerts oncogenic functions in pancreatic cancer via miR-34a-5p. Oncol Rep. 2018;39:1591–600.

    CAS  PubMed  PubMed Central  Google Scholar 

  101. Moroishi T, Hansen CG, Guan K-L. The emerging roles of YAP and TAZ in cancer. Nat Rev Cancer. 2015;15:73–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  102. Sun J, Zhang Y. LncRNA XIST enhanced TGF-β2 expression by targeting miR-141–3p to promote pancreatic cancer cells invasion. 2019. Biosci Rep. https://doi.org/10.1042/BSR20190332.

  103. Duan R, Du W, Guo W. EZH2: a novel target for cancer treatment. J Hematol Oncol. 2020;13:1–12.

    Article  Google Scholar 

  104. Wang H, Li W, Tan G. Long non-coding RNA XIST modulates cisplatin resistance by altering PDCD4 and Fas-Lexpressions in human nasopharyngeal carcinoma HNE1 cells in vitro. Nan Fang Yi Ke Da Xue Xue Bao. 2019;39:357–63.

    PubMed  Google Scholar 

  105. Zou L, Chen FR, Xia RP, Wang HW, Xie ZR, Xu Y, et al. Long noncoding RNA XIST regulates the EGF receptor to promote TGF-β1-induced epithelial-mesenchymal transition in pancreatic cancer. Biochem Cell Biol. 2020;98:267–76.

    Article  CAS  PubMed  Google Scholar 

  106. Yang X, Tao H, Wang C, Chen W, Hua F, Qian H. lncRNA-ATB promotes stemness maintenance in colorectal cancer by regulating transcriptional activity of the β-catenin pathway. Exp Ther Med. 2020;19:3097–103.

    CAS  PubMed  PubMed Central  Google Scholar 

  107. Sun J, Zhang Y. LncRNA XIST enhanced TGF-β2 expression by targeting miR-141–3p to promote pancreatic cancer cells invasion. 2019. Biosci Rep. https://doi.org/10.1042/BSR20190332.

  108. Agrelo R, Souabni A, Novatchkova M, Haslinger C, Leeb M, Komnenovic V, et al. SATB1 defines the developmental context for gene silencing by Xist in lymphoma and embryonic cells. Dev Cell. 2009;16:507–16.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  109. Parodi S. Xist noncoding RNA could act as a tumor suppressor gene in patients with classical Hodgkin’s disease. J Cancer Res Ther. 2020;16:7–12.

    Article  CAS  PubMed  Google Scholar 

  110. Liu Q, Ran R, Wu Z, Li X, Zeng Q, Xia R, et al. Long Non-coding RNA X-Inactive Specific Transcript Mediates Cell Proliferation and Intrusion by Modulating the miR-497/Bcl-w Axis in Extranodal Natural Killer/T-cell Lymphoma. Front Cell Dev Biol. 2020;8: 599070.

    Article  PubMed  PubMed Central  Google Scholar 

  111. Chen D-l, Ju H-q, Lu Y-x, Chen L-z, Zeng Z-l, Zhang D-s, et al. Long non-coding RNA XIST regulates gastric cancer progression by acting as a molecular sponge of miR-101 to modulate EZH2 expression. J Exp Clin Cancer Res. 2016;35:1–13.

    Article  Google Scholar 

  112. Li P, Wang L, Li P, Hu F, Cao Y, Tang D, et al. Silencing lncRNA XIST exhibits antiproliferative and proapoptotic effects on gastric cancer cells by up-regulating microRNA-132 and down-regulating PXN. Aging (albany NY). 2021;13:14469.

    Article  CAS  Google Scholar 

  113. Li P, Wang L, Li P, Hu F, Cao Y, Tang D, et al. Silencing of long non-coding RNA XIST represses gastric cancer progression through blocking NFκB pathway via inhibiting HNF4A-mediated transcription of EPHA1. Cancer Gene Ther. 2021;28:307–20.

    Article  CAS  PubMed  Google Scholar 

  114. Ma L, Zhou Y, Luo X, Gao H, Deng X, Jiang Y. Long non-coding RNA XIST promotes cell growth and invasion through regulating miR-497/MACC1 axis in gastric cancer. Oncotarget. 2017;8:4125.

    Article  PubMed  Google Scholar 

  115. Zhang Q, Chen B, Liu P, Yang J. XIST promotes gastric cancer (GC) progression through TGF-β1 via targeting miR-185. J Cell Biochem. 2018;119:2787–96.

    Article  CAS  PubMed  Google Scholar 

  116. Zheng W, Li J, Zhou X, Cui L, Wang Y. The lncRNA XIST promotes proliferation, migration and invasion of gastric cancer cells by targeting miR-337. Arab J Gastroenterol. 2020;21:199–206.

    Article  PubMed  Google Scholar 

  117. Du Y, Weng X-D, Wang L, Liu X-H, Zhu H-C, Guo J, et al. LncRNA XIST acts as a tumor suppressor in prostate cancer through sponging miR-23a to modulate RKIP expression. Oncotarget. 2017;8:94358.

    Article  PubMed  PubMed Central  Google Scholar 

  118. Dariya B, Chalikonda G, Alam A, Nagaraju GP. 2020 Theranostic role of RKIP in cancer. In Prognostic and Therapeutic Applications of RKIP in Cancer. Elsevier; pp. 415–434

  119. Wang Z, Yuan J, Li L, Yang Y, Xu X, Wang Y. Long non-coding RNA XIST exerts oncogenic functions in human glioma by targeting miR-137. Am J Trans Res. 1845;2017:9.

    Google Scholar 

  120. Wang Y, Li H, Chen J, Kong F, Mo Z, Wang J, et al. Overexpression of XIST facilitates cell proliferation, invasion and suppresses cell apoptosis by reducing radio-sensitivity of glioma cells via miR-329-3p/CREB1 axis. Eur Rev Med Pharmacol Sci. 2020;24:3190–203.

    PubMed  Google Scholar 

  121. Du P, Zhao H, Peng R, Liu Q, Yuan J, Peng G, et al. LncRNA-XIST interacts with miR-29c to modulate the chemoresistance of glioma cell to TMZ through DNA mismatch repair pathway. 2017. Biosci Rep. https://doi.org/10.1042/BSR20170696.

  122. Luo C, Quan Z, Zhong B, Zhang M, Zhou B, Wang S, et al. lncRNA XIST promotes glioma proliferation and metastasis through miR-133a/SOX4. Exp Ther Med. 2020;19:1641–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  123. Cheng Z, Li Z, Ma K, Li X, Tian N, Duan J, et al. Long non-coding RNA XIST promotes glioma tumorigenicity and angiogenesis by acting as a molecular sponge of miR-429. J Cancer. 2017;8:4106.

    Article  PubMed  PubMed Central  Google Scholar 

  124. Shen J, Xiong J, Shao X, Cheng H, Fang X, Sun Y, et al. Knockdown of the long noncoding RNA XIST suppresses glioma progression by upregulating miR-204-5p. J Cancer. 2020;11:4550.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  125. Yu H, Xue Y, Wang P, Liu X, Ma J, Zheng J, et al. Knockdown of long non-coding RNA XIST increases blood–tumor barrier permeability and inhibits glioma angiogenesis by targeting miR-137. Oncogenesis. 2017;6:e303–e303.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  126. Wen JF, Jiang YQ, Li C, Dai XK, Wu T, Yin WZ. LncRNA-XIST promotes the oxidative stress-induced migration, invasion, and epithelial-to-mesenchymal transition of osteosarcoma cancer cells through miR-153-SNAI1 axis. Cell Biol Int. 2020;44:1991–2001.

    Article  CAS  PubMed  Google Scholar 

  127. Gao W, Gao J, Chen L, Ren Y, Ma J. Targeting XIST induced apoptosis of human osteosarcoma cells by activation of NF-kB/PUMA signal. Bioengineered. 2019;10:261–70.

    Article  PubMed  PubMed Central  Google Scholar 

  128. Li G, Wu Y, Li Y, Li J. High expression of long non-coding RNA XIST in osteosarcoma is associated with cell proliferation and poor prognosis. Eur Rev Med Pharmacol Sci. 2017;21:2829–34.

    PubMed  Google Scholar 

  129. Liu W, Long Q, Zhang L, Zeng D, Hu B, Zhang W, et al. Long non-coding RNA X-inactive specific transcript promotes osteosarcoma metastasis via modulating microRNA-758/Rab16. Ann Transl Med. 2021. https://doi.org/10.2103/atm-21-1032.

    Article  PubMed  PubMed Central  Google Scholar 

  130. Sun X, Wei B, Peng Z-H, Fu Q-L, Wang C-J, Zheng J-C, et al. Knockdown of lncRNA XIST suppresses osteosarcoma progression by inactivating AKT/mTOR signaling pathway by sponging miR-375-3p. Int J Clin Exp Pathol. 2019;12:1507.

    CAS  PubMed  PubMed Central  Google Scholar 

  131. Zhang Y, Li J, Jia S, Wang Y, Kang Y, Zhang W. Down-regulation of lncRNA-ATB inhibits epithelial–mesenchymal transition of breast cancer cells by increasing miR-141-3p expression. Biochem Cell Biol. 2019;97:193–200.

    Article  CAS  PubMed  Google Scholar 

  132. Lv G-Y, Miao J, Zhang X-L. Long noncoding RNA XIST promotes osteosarcoma progression by targeting Ras-related protein RAP2B via miR-320b. Oncol Res. 2018;26:837.

    Article  PubMed  PubMed Central  Google Scholar 

  133. Xu T, Jiang W, Fan L, Gao Q, Li G. Upregulation of long noncoding RNA Xist promotes proliferation of osteosarcoma by epigenetic silencing of P21. Oncotarget. 2017;8: 101406.

    Article  PubMed  PubMed Central  Google Scholar 

  134. Zhang R, Xia T. Long non-coding RNA XIST regulates PDCD4 expression by interacting with miR-21-5p and inhibits osteosarcoma cell growth and metastasis. Int J Oncol. 2017;51:1460–70.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  135. Wang W, Shen H, Cao G, Huang J. Long non-coding RNA XIST predicts poor prognosis and promotes malignant phenotypes in osteosarcoma. Oncol Lett. 2019;17:256–62.

    CAS  PubMed  Google Scholar 

  136. Pan B, Lin X, Zhang L, Hong W, Zhang Y. Long noncoding RNA X-inactive specific transcript promotes malignant melanoma progression and oxaliplatin resistance. Melanoma Res. 2019;29:254–62.

    Article  CAS  PubMed  Google Scholar 

  137. Ouyang F, Liu J, Xia M, Lin C, Wu X, Ye L, et al. GINS2 is a novel prognostic biomarker and promotes tumor progression in early-stage cervical cancer. Oncol Rep. 2021;45:1–2.

    Article  Google Scholar 

  138. Hao Y-Q, Liu K-W, Zhang X, Kang S-X, Zhang K, Han W, et al. GINS2 was regulated by lncRNA XIST/miR-23a-3p to mediate proliferation and apoptosis in A375 cells. Mol Cell Biochem. 2021;476:1455–65.

    Article  CAS  PubMed  Google Scholar 

  139. Zhang Y, Liu J, Gao Y, Zhang Z, Zhang H: Long noncoding RNA XIST acts as a competing endogenous RNA to promote malignant melanoma growth and metastasis by sponging miR-217. Panminerva Med. 2019. https://doi.org/10.23736/S0031-0808.19.03746-7.

  140. Sun K, Jia Z, Duan R, Yan Z, Jin Z, Yan L, et al. Long non-coding RNA XIST regulates miR-106b-5p/P21 axis to suppress tumor progression in renal cell carcinoma. Biochem Biophys Res Commun. 2019;510:416–20.

    Article  CAS  PubMed  Google Scholar 

  141. Gharbaran R. Advances in the molecular functions of syndecan-1 (SDC1/CD138) in the pathogenesis of malignancies. Crit Rev Oncol Hematol. 2015;94:1–17.

    Article  PubMed  Google Scholar 

  142. Zhang J, Cao Z, Ding X, Wei X, Zhang X, Hou J, et al. The lncRNA XIST regulates the tumorigenicity of renal cell carcinoma cells via the miR-302c/SDC1 axis. Int J Clin Exp Pathol. 2017;10:7481.

    PubMed  PubMed Central  Google Scholar 

  143. Xu Y, Wang J, Wang J. Long noncoding RNA XIST promotes proliferation and invasion by targeting miR-141 in papillary thyroid carcinoma. Onco Targets Ther. 2018;11:5035.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  144. Du Y-L, Liang Y, Cao Y, Liu L, Li J, Shi G-Q. LncRNA XIST promotes migration and invasion of papillary thyroid cancer cell by modulating MiR-101-3p/CLDN1 axis. Biochem Genet. 2021;59:437–52.

    Article  CAS  PubMed  Google Scholar 

  145. Liu H, Deng H, Zhao Y, Li C, Liang Y. LncRNA XIST/miR-34a axis modulates the cell proliferation and tumor growth of thyroid cancer through MET-PI3K-AKT signaling. J Exp Clin Cancer Res. 2018;37:1–12.

    Article  PubMed  PubMed Central  Google Scholar 

  146. Zhang Y, Zhu Z, Huang S, Zhao Q, Huang C, Tang Y, et al. lncRNA XIST regulates proliferation and migration of hepatocellular carcinoma cells by acting as miR-497-5p molecular sponge and targeting PDCD4. Cancer Cell Int. 2019;19:1–13.

    Google Scholar 

  147. Rupaimoole R, Slack FJ. MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Nat Rev Drug Discov. 2017;16:203–22.

    Article  CAS  PubMed  Google Scholar 

  148. Mo Y, Lu Y, Wang P, Huang S, He L, Li D, et al. Long non-coding RNA XIST promotes cell growth by regulating miR-139-5p/PDK1/AKT axis in hepatocellular carcinoma. Tumor Biol. 2017;39:1010428317690999.

    Article  CAS  Google Scholar 

  149. Zhuang L, Yang Y, Ma X, Han B, Wang Z, Zhao Q, et al. MicroRNA-92b promotes hepatocellular carcinoma progression by targeting Smad7 and is mediated by long non-coding RNA XIST. Cell Death Dis. 2016;7:e2203–e2203.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  150. Liu W, Xu Q. Long non-coding RNA XIST promotes hepatocellular carcinoma progression by sponging miR-200b-3p. Eur Rev Med Pharmacol Sci. 2019;23:9857–62.

    PubMed  Google Scholar 

  151. Chang S, Chen B, Wang X, Wu K, Sun Y. Long non-coding RNA XIST regulates PTEN expression by sponging miR-181a and promotes hepatocellular carcinoma progression. BMC Cancer. 2017;17:1–14.

    Article  Google Scholar 

  152. Wang J, Yin G, Bian H, Yang J, Zhou P, Yan K, et al. LncRNA XIST upregulates TRIM25 via negatively regulating miR-192 in hepatitis B virus-related hepatocellular carcinoma. Mol Med. 2021;27:1–10.

    Article  PubMed  PubMed Central  Google Scholar 

  153. Dong Z, Yang J, Zheng F, Zhang Y. The expression of lncRNA XIST in hepatocellular carcinoma cells and its effect on biological function. J BUON. 2020;25:2430–7.

    PubMed  Google Scholar 

  154. Lin X-q, Huang Z-m. Chen X, Wu F, Wu W: XIST induced by JPX suppresses hepatocellular carcinoma by sponging miR-155-5p. Yonsei Med J. 2018;59:816–26.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  155. Weakley SM, Wang H, Yao Q, Chen C. Expression and function of a large non-coding RNA gene XIST in human cancer. World J Surg. 2011;35:1751–6.

    Article  PubMed  PubMed Central  Google Scholar 

  156. Kobayashi R, Miyagawa R, Yamashita H, Morikawa T, Okuma K, Fukayama M, et al. Increased expression of long non-coding RNA XIST predicts favorable prognosis of cervical squamous cell carcinoma subsequent to definitive chemoradiation therapy. Oncol Lett. 2016;12:3066–74.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  157. Xu C, Tian L. LncRNA XIST promotes proliferation and epithelial-mesenchymal transition of retinoblastoma cells through sponge action of miR-142-5p. Eur Rev Med Pharmacol Sci. 2020;24:9256–64.

    CAS  PubMed  Google Scholar 

  158. Fu N, Zhao S-X, Kong L-B, Du J-H, Ren W-G, Han F, et al. LncRNA-ATB/microRNA-200a/β-catenin regulatory axis involved in the progression of HCV-related hepatic fibrosis. Gene. 2017;618:1–7.

    Article  CAS  PubMed  Google Scholar 

  159. Jiang X, Guo S, Zhang Y, Zhao Y, Li X, Jia Y, et al. LncRNA NEAT1 promotes docetaxel resistance in prostate cancer by regulating ACSL4 via sponging miR-34a-5p and miR-204-5p. Cell Sig. 2020;65: 109422.

    Article  CAS  Google Scholar 

  160. Lee SH, Kim SW, Nam EJ, Park JS, Kim JW, Kim YT. The functional role and clinical significance of long non-coding RNA in cervical cancer. Gynecol Oncol. 2019;154:84.

    Article  Google Scholar 

  161. Swellam M, Hekmat ME, Shawki MA, Adel M, Hefny MM, El-Shazly SS. Clinical impact of LncRNA XIST and LncRNA NEAT1 for diagnosis of high-risk group breast cancer patients. Curr Probl Cancer. 2021;45:100709.

    Article  PubMed  Google Scholar 

Download references

Funding

Not applicable.

Author information

Authors and Affiliations

  1. Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Maryam Farzaneh

  2. Infectious Ophthalmologic Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Ava Nasrolahi

  3. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

    Farhoodeh Ghaedrahmati

  4. Laboratory of Molecular and Metabolic Imaging, Cancer Research Department, Sidra Medicine, 26999, Doha, Qatar

    Tariq Masoodi

  5. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Sajad Najafi

  6. Department of Laboratory, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

    Mohadeseh Sheykhi-Sabzehpoush

  7. Department of Obstetrics and Gynecology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Mahrokh Abouali Gale Dari

  8. Translational Platform for Regenerative Medicine, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland

    Klaudia Radoszkiewicz

  9. Translational Research Institute and Dermatology Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar

    Shahab Uddin

  10. Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Shirin Azizidoost

  11. Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Seyed Esmaeil Khoshnam

Authors
  1. Maryam Farzaneh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ava Nasrolahi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Farhoodeh Ghaedrahmati
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Tariq Masoodi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Sajad Najafi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Mohadeseh Sheykhi-Sabzehpoush
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Mahrokh Abouali Gale Dari
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Klaudia Radoszkiewicz
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Shahab Uddin
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Shirin Azizidoost
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Seyed Esmaeil Khoshnam
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

MF, AN, FGH, TM, SN, MSHS, MAGD, KR, SHU, SH. A, and SE KH. have made contributions to the writing of the manuscript. All authors have approved the submitted version of the article and have agreed to be personally accountable for the author’s own contributions and to ensure that questions related to the accuracy or integrity of any part of the work. All authors read and approved the final manuscript.

Corresponding authors

Correspondence to Shirin Azizidoost or Seyed Esmaeil Khoshnam.

Ethics declarations

Conflict of interest

The authors declare that there are no competing interests.

Ethical approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Farzaneh, M., Nasrolahi, A., Ghaedrahmati, F. et al. Potential roles of lncRNA-XIST/miRNAs/mRNAs in human cancer cells. Clin Transl Oncol 25, 2015–2042 (2023). https://doi.org/10.1007/s12094-023-03110-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12094-023-03110-y

Keywords

Search

Navigation