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Topography of the sentinel node according to the affected lobe in lung cancer

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Abstract

Purpose

The objective of this study is to describe the anatomic location of the sentinel lymph node (SLN) of patients with lung carcinoma and to analyze its relationship with the characteristics of the tumor.

Patients and methods

98 Stage I lung cancer patients were included in the study. SLN was marked just after performing the thoracotomy by injecting peritumorally 0.25 mCi of nanocolloid of albumin (Nanocol1) labeled with Tc-99 m in 0.3 ml, and later, it was resected. For SLN micrometastasis analysis, CEACAM5, BPIFA1, and CK7 gene expression at mRNA level was studied. Possible relation between tumor characteristics and SLN location was analyzed.

Results

While most of the SLN were located in hilar area, we find a significantly higher number of SLN located in mediastinal stations when the lesion is in the left upper lobe (LUL). This difference disappears in the group of SLN with a positive result in the micrometastasis study. Regarding tumor size, squamous tumors and tumors located in the left lower lobe (LLL) were found significantly larger.

Conclusion

The location of the SLN in patients with stage I lung cancer is predominantly hilar, being less consistent in the left hemithorax. The tumor size or histological type is not variables that affect this distribution. The distribution of SLNs with a positive result in the analysis of micrometastasis suggests further spread to the hilar areas when the lesion is in the LUL and to the mediastinal zones when it is in the LLL.

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Authors and Affiliations

  1. Servicio de Cirugía Torácica, Del Hospital Universitario de La Ribera, Alcira, Spain

    J. M. Galbis-Caravajal, M. Estors-Guerrero & N. Martinez-Hernández

  2. Servicio de Biología Molecular, Del Hospital Universitario de La Ribera, Crta. Corbera, km. 1, 46600, Alcira, Valencia, Spain

    A. Lafuente-Sanchis & Á. Zúñiga

  3. Unidad Funcional de Mama, Del Hospital General Universitario de Valencia, Valencia, Spain

    C. Fuster-Diana

  4. Servicio y de Anatomía Patológica, Del Hospital Universitario de La Ribera, Alcira, Spain

    A. Cremades

Authors
  1. J. M. Galbis-Caravajal
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  2. A. Lafuente-Sanchis
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  3. M. Estors-Guerrero
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  4. N. Martinez-Hernández
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  5. C. Fuster-Diana
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  6. A. Cremades
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  7. Á. Zúñiga
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Corresponding author

Correspondence to A. Lafuente-Sanchis.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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None.

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Informed consent was obtained from all individual participants included in the study.

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Galbis-Caravajal, J.M., Lafuente-Sanchis, A., Estors-Guerrero, M. et al. Topography of the sentinel node according to the affected lobe in lung cancer. Clin Transl Oncol 19, 858–864 (2017). https://doi.org/10.1007/s12094-017-1615-4

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  • DOI: https://doi.org/10.1007/s12094-017-1615-4

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