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Association of the Laennec staging system with degree of cirrhosis, clinical stage and liver function

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Abstract

Objectives

The aim of this study was to investigate the association of the Laennec staging system with degree of cirrhosis, clinical stage and liver function.

Methods

Liver biopsy was performed for 30 patients with hepatitis B cirrhosis to test the content of hydroxyproline in hepatic tissue, judge the degree of cirrhosis and determine the Laennec staging system. The association of the Laennec staging system with the degree of cirrhosis, clinical stage and liver function was compared.

Results

The Laennec staging system had a close association with clinical stage, model for end-stage liver disease score and degree of cirrhosis (r = 0.58, p < 0.01; r = 0.60, p < 0.01; r = 0.53, p < 0.01).

Conclusions

The Laennec histological grading system can to some extent reflect the degree of cirrhosis, clinical stage and liver function, and is expected to predict the incidence of patient complications in a useful way.

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Funding

The key project of the clinical specialist by National Health and Family Planning Commission of the People’s Republic of China; the joint project of the school enterprise.

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Authors and Affiliations

  1. Department of Hepatobiliary Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China

    Wei Wang, Jiye Li, Runhua Pan, Sileng A & Caixian Liao

Authors
  1. Wei Wang
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  2. Jiye Li
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  3. Runhua Pan
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  4. Sileng A
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  5. Caixian Liao
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Corresponding author

Correspondence to Caixian Liao.

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Conflict of interest

Wei Wang, Jiye Li, Runhu Pan, A. Sileng, and Caixian Liao declare that they have no conflict of interest.

Ethical standard

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008.

Informed consent

Informed consent was obtained from all patients for being included in the study

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Wang, W., Li, J., Pan, R. et al. Association of the Laennec staging system with degree of cirrhosis, clinical stage and liver function. Hepatol Int 9, 621–626 (2015). https://doi.org/10.1007/s12072-015-9648-7

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  • DOI: https://doi.org/10.1007/s12072-015-9648-7

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