Abstract
Background
Metastasis to parapharyngeal space in papillary carcinoma of the thyroid is rare and often missed in routine clinical and radiological investigations. Although contrast CT /MRI can be done to locate the parapharyngeal lesion, the diagnosis of metastasis mostly deepened upon aspiration cytology, which is a challenge in difficult anatomical locations. Here, we have emphasized the management dilemma of parapharyngeal metastasis in papillary carcinoma of the thyroid.
Case Report
A 30-year-old female presented with multiple right-side neck swelling for two months. Ultrasonography of right thyroid showed TIRAD V and left thyroid showed TIRAD II. Aspiration cytology of the right thyroid showed Bethesda III and aspiration cytology revealed thyroid follicles. Due to the diagnostic ambiguity, contrast-enhanced CT scan was advised. It revealed a hypervascular lymph node in the parapharyngeal space besides multiple right cervical lymph nodes and later changed the treatment plan.
Conclusion
- Metastasis to parapharyngeal space in Papillary carcinoma of the thyroid is rare and often missed on routine evaluation. Contrast-enhanced CT/MRI can be added as a primary investigation in challenging cases of suspicious malignancy of the thyroid.
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References
Davies L, Welch HG (2014) Current thyroid cancer trends in the United States. JAMA Otolaryngol Head Neck Surg 140(4):317–322
Moritani S (2016) Parapharyngeal metastasis of papillary thyroid carcinoma. World J Surg 40(2):350–355
Sandler ML, Xing MH, Levy JC, Chai RL, Khorsandi AS, Gonzalez-Velazquez C et al (2021) Metastatic thyroid carcinoma to the parapharyngeal and retropharyngeal spaces: systematic review with seven newly reported cases describing an uncommon presentation of a common disease. Head Neck 43(4):1331–1344
Ranganath R, Dhillon VK, Shaear M, Rooper L, Russell JO, Tufano RP (2020) Unusual locations for differentiated thyroid cancer nodal metastasis. World J Otorhinolaryngol - head Neck Surg 6(3):176–181
Iwanaga J, Lofton C, He P, Dumont AS, Tubbs RS (2021) Lymphatic system of the Head and Neck. J Craniofac Surg 32(5):1901–1905
El Khiati R, Ouaissi L, Rouadi S, Abada R, Mahtar M, Roubal M et al (2013) [Axillary metastasis of papillary thyroid carcinoma: report of a case]. Pan Afr Med J 16:12
Qiu Z-L, Xu Y-H, Song H-J, Luo Q-Y (2011) Localization and identification of parapharyngeal metastases from differentiated thyroid carcinoma by 131I-SPECT/CT. Head Neck 33(2):171–177
Lombardi D, Nicolai P, Antonelli AR, Maroldi R, Farina D, Shaha AR (2004) Parapharyngeal lymph node metastasis: an unusual presentation of papillary thyroid carcinoma. Head Neck 26(2):190–196
McMillan B, Jones R, Ward-Booth P, Goss A (1999) Technique for intraoral inverted L osteotomy. Br J Oral Maxillofac Surg 37(4):324–326
Nabil S, Nazimi AJ, Nordin R, Hariri F, Mohamad Yunus MR, Zulkiflee AB (2018) Mandibulotomy: an analysis of its morbidities. Int J Oral Maxillofac Surg 47(12):1511–1518
Campagnoli M, Masnaghetti D, Rosa MS, Paganelli E, Garzaro M, Aluffi Valletti P (2023) Parapharyngeal Metastasis of Papillary Carcinoma of thyroid gland: a Case Report and a review of the literature. Diagnostics 13(8):1–8
Hartl DM, Leboulleux S, Vélayoudom-Céphise F-L, Mirghani H, Déandréis D, Schlumberger M (2015) Management of retropharyngeal node metastases from thyroid carcinoma. World J Surg 39(5):1274–1281
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Mishra, A.K., Pradhan, P., Chakraborty, S. et al. Parapharyngeal Nodal Metastasis in Papillary Thyroid Carcinoma: Catching Early. Indian J Otolaryngol Head Neck Surg (2024). https://doi.org/10.1007/s12070-024-04482-5
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DOI: https://doi.org/10.1007/s12070-024-04482-5