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Long Term Health-Related Quality of Life with Differentiated Thyroid Cancer in Goiter Endemic Area

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Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

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Abstract

Health related quality of life (HRQOL) is a multidimensional concept that encompasses the patient’s perceptions of his or her physical, emotional, social, and cognitive functions. Despite DTC patients' long survival, HRQOL has been shown to be lower than in the general population. There is a scarcity of data on HRQOL in thyroid cancer in the Indian population and especially goiter endemic area. As a result, the authors conducted a health-related quality of life survey in patients managed at their center in Northern India's Sub-Himalayan region using two widely accepted questionnaires. Adults with differentiated thyroid cancer who had surgery with or without radio-iodine ablation and had recovered for at least 6 months were assessed using health quality of life surveys, the QLQ-C30 and QLQ-THY34 of the European Organization for Research and Treatment of Cancer Quality of Life Group. The survey was completed by 57 adults with a mean age of 45.64 ± 15.64 years. The average time between the survey and treatment was 13.3 ± 10.8 months. After surgery, the QLQ-C30 found a significant reduction in insomnia, appetite loss, constipation, diarrhea, and financial difficulties, whereas radio-iodine ablation significantly improved global health status. The QLQ-THY34 found a significant increase in symptoms such as voice concerns, hair problems, dry mouth, shoulder functioning, tingling, and worrying after surgery, with a significant improvement in swallowing and job impact symptoms. The surgical extent had no impact. The quality of life for people with differentiated thyroid cancer in goiter-endemic areas is similar to that of other areas. However, the limited number of subjects in the study warrants further large sample size longitudinal study to understand the exact Health-related quality of life in thyroid cancer in endemic area.

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Data Availability

The data that support the findings of this study is available on reasonable request from Sheetal Thakur or Jagdeep S. Thakur.

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Funding

No funding was received for this study.

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Authors and Affiliations

  1. Department of Otolaryngology-Head Neck Surgery (ENT), Indira Gandhi Medical College, Shimla, 171001, India

    Sheetal Thakur, Ramesh K. Azad, Ishan Chauhan & Jagdeep S. Thakur

Authors
  1. Sheetal Thakur
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  2. Ramesh K. Azad
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  3. Ishan Chauhan
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  4. Jagdeep S. Thakur
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Contributions

ST and JT: Conception, methodology, data collection and analysis, draft and final approval. RKA and IC: Methodology, critical review and final approval. All authors approved the final manuscript.

Corresponding author

Correspondence to Jagdeep S. Thakur.

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Conflict of interest

The authors have no conflicts of interest to declare.

Ethical Approval

The study was approved by the Institutional Ethics Committee of IGMC, Shimla with approval number HFW(MC-II)B(12)Ethics/2021/364 dated 07th Jan 2022.

Consent to Participate

A written informed consent was obtained from all the participants (or their parent/legal guardian/next of kin) to participate in the study.

Human and Animal Rights

Published research complies with the guidelines for human studies and research was conducted ethically in accordance with the World Medical Association Declaration of Helsinki.

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Thakur, S., Azad, R.K., Chauhan, I. et al. Long Term Health-Related Quality of Life with Differentiated Thyroid Cancer in Goiter Endemic Area. Indian J Otolaryngol Head Neck Surg 75, 3130–3135 (2023). https://doi.org/10.1007/s12070-023-03936-6

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  • DOI: https://doi.org/10.1007/s12070-023-03936-6

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