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Adult-onset Recurrent Respiratory Papillomatosis at a South African Referral Hospital

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Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

Objective

The aim of this study was to describe the clinical presentation and outcome of patients with adult-onset recurrent respiratory papillomatosis (AoRRP) in a developing country with the challenges of poor health care access and high prevalence of HIV infection.

Materials and methods

This was a retrospective study of patients diagnosed with AoRRP who were managed in the Department of Otorhinolaryngology at Universitas Academic Hospital in Bloemfontein, South Africa over a 10 year period.

Results

There were a total of 41 patients, of which 26 (63.4%) were male. The age at diagnosis ranged between 16.4 and 67.4 years (mean 39.4 ± 14.9 years). All patients presented with a hoarse voice, with three patients also having upper airway obstruction. Eight (19.5%) patients were HIV positive. HPV typing was performed in 29 patients; 14 had HPV11 disease, 12 had HPV6 disease and in 3 patients HPV DNA was not detected. There was no significant difference in initial presentation or outcome between HIV negative and HIV positive patients, or between patients with HPV6 and HPV11 disease. Two patients had malignant transformation of the papillomas. In both these patients, HPV was not detected in the papillomas.

Conclusions

HPV type and HIV infection did not appear to influence the clinical presentation and outcome in patients with AoRRP. There is a risk of malignant transformation in patients in which HPV is not detected in the papillomas.

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Data Availability

Available from the corresponding author on reasonable request.

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Funding

No funding was received for conducting this study.

Author information

Authors and Affiliations

  1. Department of Otorhinolaryngology, Faculty of Health Sciences, University of the Free State, P.O. Box 339, 9300, Bloemfontein, South Africa

    Samukelisiwe R. Sibeko & Riaz Y. Seedat

  2. Department of Otorhinolaryngology, Universitas Academic Hospital, Bloemfontein, South Africa

    Samukelisiwe R. Sibeko & Riaz Y. Seedat

Authors
  1. Samukelisiwe R. Sibeko
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  2. Riaz Y. Seedat
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Contributions

Conceptualization: RYS. Study design: SRS, RYS. Data collection: SRS. Analysis and interpretation of data: SRS, RYS. Manuscript preparation: SRS, RYS.

Corresponding author

Correspondence to Riaz Y. Seedat.

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Conflicts of interest/Competing interests

The authors declare that they have no conflict of interest.

Ethics approval

This study was approved by the Health Sciences Research Ethics Committee of the University of the Free State (UFS-HSD2019/0256). Permission to perform the study was obtained from the Free State Department of Health.

Additional information

Presented at the 13th Congress of the European Laryngological Society, 28 May 2021.

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Sibeko, S.R., Seedat, R.Y. Adult-onset Recurrent Respiratory Papillomatosis at a South African Referral Hospital. Indian J Otolaryngol Head Neck Surg 74 (Suppl 3), 5188–5193 (2022). https://doi.org/10.1007/s12070-022-03110-4

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  • DOI: https://doi.org/10.1007/s12070-022-03110-4

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