Abstract
The Upper AeroDigestive Tract (UADT) cancers are most common, invasive and have high morbidity. The two leading risk factors, smoking and alcohol, are well known but there is a long list of other risk factors which are not that well talked about. The aim of this study was to ascertain the dietary factors which could be important in their prevention.The PubMed and Google Scholar databases were searched for relevant studies from January 2001 to November 2021. Refined grains were found directly related to the risk of UADT cancer while the whole grain cereals were found protective. Significant inverse associations were observed for the highest compared to the lowest tertile of whole grains and yellow/orange vegetables. Stricter adherence to the Mediterranean diet was seen associated with a substantial and significant decrease in UADT cancer risk. A significant inverse association was also found between yoghurt intake and UADT cancer risk. Consumption of three or more cups of coffee per day was found to have a significant inverse association with UADT cancer. Carcinogenicity of cannabis consumption was observed for regular cannabis smokers (> 1 per day for years). The current study concludes that the protective dietary factors have substantial activity in the prevention of UADT cancer. Nevertheless, basic research is required in investigating the role of these dietary factors and valid biomarkers will be important for chemoprevention studies. The basic research on risk factors on the basis of current knowledge would ultimately lead to the better prevention of UADT cancer.
Similar content being viewed by others
References
Gao J, Panizza B, Johnson NW, Coman S et al (2012) Basic consideration of research strategies for head and neck cancer. Front Med 6(4):339–353
Bloching MB, Barnes J, Aust W et al (2007) Saliva as a biomarker for head and neck squamous cell carcinoma: in vitro detection of cytotoxic effects by using the plating efficiency index. Oncol Rep 18(6):1551–1556
Ohkoshi A, Suzuki T, Ono M et al (2013) Roles of Keap1-Nrf2 system upper aerodigestive tract carcinogenesis. Cancer Prev Res (Phila) 6(2):149–159
Bongers V, Snow GB, de Vries N et al (1995) Second primary head and neck squamous cell carcinoma predicted by the glutathione S-transferase expression in healthy tissue in the direct vicinity of the first tumor. Lab Invest 73(4):503–510
Bansal M (2021) Diseases of ear, nose and throat. 3rd ed. Jaypee Brothers Medical Publishers, New Delhi. ISBN: 978-93-86150-23-3
Döbrossy L (2005) Epidemiology of head and neck cancer: magnitude of the problem. Cancer Metastasis Rev 24(1):9–17
Gustin DM (2004) Chemoprevention of head and neck cancer. SeminOncol 31(6):769–777
Kawakita D, Sato F, Hosono S et al (2012) Inverse association between yoghurt intake and upper aerodigestive tract cancer risk in a Japanese population. Eur J Cancer Prev 21(5):453–459
EscribanoUzcudun A, RabanalRetolaza I, García Grande A et al (2002) Pharyngeal cancer prevention: evidence from a case–control study involving 232 consecutive patients. J Laryngol Otol 116(7):523–531
Schmeisser N, Conway DI, McKinney PA et al (2010) Life course social mobility and risk of upper aerodigestive tract cancer in men. Eur J Epidemiol 25(3):173–182
Samoli E, Lagiou A, Nikolopoulos E et al (2010) Mediterranean diet and upper aerodigestive tract cancer: the Greek segment of the Alcohol-Related Cancers and Genetic Susceptibility in Europe study. Br J Nutr 104(9):1369–1374
Oze I, Matsuo K, Kawakita D et al (2014) Coffee and green tea consumption is associated with upper aerodigestive tract cancer in Japan. Int J Cancer 135:391–400
Carriot F, Sasco AJ (2000) Cannabis and cancer. Rev EpidemiolSantePublique 48(5):473–483
Pelucchi C, Bosetti C, Rossi M et al (2009) Selected aspects of Mediterranean diet and cancer risk. Nutr Cancer 61(6):756–766
Oze I, Matsuo K, Hosono S et al (2010) Comparison between self-reported facial flushing after alcohol consumption and ALDH2 Glu504Lys polymorphism for risk of upper aerodigestive tract cancer in a Japanese population. Cancer Sci 101(8):1875–1880
Izzo JG, Papadimitrakopoulou VA, Liu DD et al (2003) Cyclin D1 genotype, response to biochemoprevention, and progression rate to upperaerodigestive tract cancer. J Natl Cancer Inst 95(3):198–205
Levi F, Pasche C, Lucchini F et al (2000) Refined and whole grain cereals and the risk of oral, oesophageal and laryngeal cancer. Eur J ClinNutr 54(6):487–489
Kasum CM, Jacobs DR Jr, Nicodemus K et al (2002) Dietary risk factors for upper aerodigestive tract cancers. Int J Cancer 99(2):267–272
Ahrens W, Pohlabeln H, Foraita R et al (2014) Oral health, dental care and mouthwash associated with upper aerodigestive tract cancer risk in Europe: the ARCAGE study. Oral Oncol 50:616–625
Bosetti C, Gallus S, Trichopoulou A (2003) Influence of the Mediterranean diet on the risk of cancers of the upper aerodigestive tract. Cancer Epidemiol Biomarkers Prev 12(10):1091–1094
World Cancer Research Fund. WorldwideCancer Data. https://www.wcfr.org/dietandcancer/cancer-trend/worldwide-cancer-data()
Garavello W, Lucenteforte E, Bosetti C, Talamini R, Levi F, Tavani A, Franceschi S, Negri E, Vecchia CL (2009) Diet diversity and the risk of laryngeal cancer: a case-control study from Italy and Switzerland. Oral Oncol. [CrossRef] [PubMed]
Turati F, Bravi F, Polesel J, Bosetti C, Negri E, Garavello W, Taborelli M, Serraino D, Libra M, Montella M et al (2017) Adherence to the Mediterranean diet and nasopharyngeal cancer risk in Italy. Cancer Causes Control 28:89–95
Chang ET, Adami HO (2006) The enigmatic epidemiology of nasopharyngeal carcinoma. Cancer Epidemiol Biomark Prev
Li WQ, Park Y, Wu JW, Goldstein AM, Taylor PR, Hollenbeck AR, Freedman ND, Abnet CC (2014) Index-based dietary patterns and risk of head and neck cancer in a large prospective study. Am J Clin Nutr 99:559–566
Jemal A, Bray F, Ferlay J (2011) Global cancer statistics: (2011) CA Cancer J Clin 61:69–90. VC 2011 American Cancer Society, Inc.
Filomeno M, Bosetti C, Garavello W, Levi F, Galeone C, Negri E, La Vecchia C (2014) The role of a Mediterranean diet on the risk of oral and pharyngeal cancer. Br J Cancer 111:981–986
Funding
The authors did not receive support from any organization for the submitted work. No funding was received to assist with the preparation of this manuscript. No funding was received for conducting this study. No funds, grants, or other support were received.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors have no relevant financial or non-financial interests to disclose. The authors have s no competing interests to declare that are relevant to the content of this article. The authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript. The authors have no financial or proprietary interests in any material discussed in this article.
Ethical Standards
As all the enrolled studies were previously published studies, no ethical approval or patient consent was required.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Bansal, M., Gupta, T.K. Dietary Risk Factors in Upper Aero-Digestive Tract Cancers. Indian J Otolaryngol Head Neck Surg 74 (Suppl 3), 6356–6361 (2022). https://doi.org/10.1007/s12070-022-03093-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12070-022-03093-2