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A Review on Esthesioneuroblastoma

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Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

Background Esthesioneuroblastoma (ENB) is a rare, aggressive and malignant sinonasal tumour. This tumour makes for a very interesting study because ever since its mention in medical literature, although quite a lot of research has been put into it, a lot is yet to be known about it. Aim To summarize the available literature & document an article on the contemporary practises in the management of ENB. Methods A comprehensive literature review was done using Google Scholar and PubMed database with the key words: “esthesioneuroblastoma”, “olfactory neuroblastoma”, “Kadish” and “Hyams”. Articles published in English were used. Articles published till April 2021 were reviewed. Conclusion ENB has a diverse histological appearance. This tumour has a bimodal age distribution without any gender predilection. Prompt identification and treatment is required for a favourable outcome and requires close collaboration of radiology, pathology, and rhinology. Staging, management and prognosis are determined by regional involvement in non-metastatic cases due to its proximity to neurological structures and locally destructive nature. Immunohistochemistry is a must for accurate diagnosis. Uni-modality of treatment has high chances of local recurrence. Multi-modality provides good results even in advanced stage. A combination of surgery and radiotherapy seems to be the optimum approach to treatment. The exact role of chemotherapy in treatment protocols is still unclear. Cervical lymph node metastases are commonly studied, however its management in patients who present without apparent nodal involvement is not yet clear. An extended follow-up period is recommended in all patients of ENB patients.

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References

  1. Factors P (2007) A population-based analysis of survival and prognostic factors, 133: 276–280

  2. Raj GS, Rao GV, Kumar MP, Sudheerkanth K (2016) Maxillofacial esthesioneuroblastoma: a diagnostic complexity. J Oral Maxillofac Pathol 20(2):331. https://doi.org/10.4103/0973-029X.185922

    Article  PubMed Central  PubMed  Google Scholar 

  3. McVey GP, Power DG, Aherne NJ, Gibbons D, Carney DN (2009) Post irradiation olfactory neuroblastoma (esthesioneuroblastoma): a case report and up to date review. Acta Oncol (Madr) 48(6):937–940. https://doi.org/10.1080/02841860902759709

    Article  Google Scholar 

  4. Stamenov B, Tzvetanov P, Simeonova V, Nikolova M (2005) Olfactory neuroblastoma: clinical presentation and management. JofIMAB 11:24–25

    Google Scholar 

  5. Gamrot-Wrzoł M, Sowa P, Lisowska G, Ścierski W, Misiołek M (2017) Risk factors of recurrence and malignant transformation of sinonasal inverted papilloma. Biomed Res Int 2017:9195163. https://doi.org/10.1155/2017/9195163

  6. Gandhoke CS, Dewan A, Gupta D, Syal SK, Jagetia A, Saran RK (2020) A rare case report of mixed olfactory neuroblastoma: carcinoma with review of literature. Surg Neurol Int 8:1–11

    Google Scholar 

  7. Ghaffar S, Salahuddin I (2005) Olfactory neuroblastoma: a case report and review of the literature. Ear, Nose Throat J 84(3):150–152. https://doi.org/10.1177/014556130508400311

    Article  PubMed  Google Scholar 

  8. Thripthi Rai K, Lobo FD, Vijendra Shenoy S, Sushmitha K (2020) A clinicopathological study of olfactory neuroblastoma. Egypt J Ear Nose Throat Allied Sci 21(3):133–137. https://doi.org/10.21608/ejentas.2020.22455.1169

    Article  Google Scholar 

  9. Ansari S, Ahmad K, Dhungel K, Gupta MK, Amanullah F (2013) “Esthesioneuroblastoma one of the causes of proptosis. Head Face Med. https://doi.org/10.1186/1746-160X-9-19

    Article  PubMed Central  PubMed  Google Scholar 

  10. Haroon S, Tariq MU, Memon A, Fatima S, Hasan SH (2015) Olfactory neuroblastoma: a clinicopathological experience of a rare entity from Pakistan. Pak J Med Sci 32:585–590. https://doi.org/10.12669/pjms.323.9738

    Article  Google Scholar 

  11. Dulguerov P, Allal AS, Calcaterra TC (2000) Esthesioneuroblastoma: a meta-analysis and review. Lancet Oncol 2:683–690

    Article  Google Scholar 

  12. Ansari J, Glaholm J (2012) Management of a unknown primary carcinoma. In: W. C. John, Ralph W Gilbert (Eds) Stell & Maran’s Textbook of Head and Neck Surgery and Oncology, 5th edn. CRC Press, Taylor and Francis Group, Boca Raton, FL 33487–2742

  13. Kondo N, Takahashi H, Nii Y, Nagao J (2012) Olfactory neuroblastoma: 15 years of experience. Anticancer Res 32(5):1697–1704

    CAS  PubMed  Google Scholar 

  14. Howell MC, Branstetter BF IV, Snyderman CH (2011) Patterns of regional spread for esthesioneuroblastoma. Am J Neuroradiol 32(5):929–933. https://doi.org/10.3174/ajnr.A2401

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  15. Leticia et al., RN (2020) Olfactory neuroblastoma: everything radiologists should know, 84(1): 17–31

  16. Gallia GL et al (2019) Endonasal endoscopic resection of olfactory neuroblastoma: an 11-year experience. J Neurosurg 131(1):238–244. https://doi.org/10.3171/2018.2.JNS171424

    Article  Google Scholar 

  17. Kahmke RR, Van Arnam J, Puscas L (2016) Radiation-Induced Olfactory Neuroblastoma, 3: 1–4

  18. Viewbox THE (2016) FROM THE VIEWBOX Olfactory Neuroblastoma, 31(1): 65–66

  19. Adler JR et al (2020) Esthesioneuroblastoma: an unusual presentation with intractable headache. Cureus 10(11):1–8. https://doi.org/10.7759/cureus.3653

    Article  Google Scholar 

  20. Gallia GL et al (2018) Genomic analysis identifies frequent deletions of dystrophin in olfactory neuroblastoma. Nat Commun 9(1):1–6. https://doi.org/10.1038/s41467-018-07578-z

    Article  CAS  Google Scholar 

  21. Czapiewski P, Kunc M, Haybaeck J (2016) Genetic and molecular alterations in olfactory neuroblastoma—implications for pathogenesis, prognosis and treatment. Oncotarget 7(32):52584–52596. https://doi.org/10.18632/oncotarget.9683

    Article  PubMed Central  PubMed  Google Scholar 

  22. Lazo L et al (2017) Comprehensive molecular pro fi ling of olfactory neuroblastoma identifies potentially targetable FGFR3 amplifications. Mol Cancer Res. pp. 1–8. https://doi.org/10.1158/1541-7786.MCR-17-0135

    Article  Google Scholar 

  23. Kumar R, Kumar R, Delhi N, Nagar A (2020) Esthesioneuroblastoma: Multimodal management and review of literature. World J Clin Cases 3(9):774–778. https://doi.org/10.12998/wjcc.v3.i9.774

    Article  Google Scholar 

  24. Benfari G et al (2008) Radiotherapy alone for local tumour control in esthesioneuroblastoma. Acta Otorhinolaryngol Ital 28(6):292–297

    CAS  PubMed Central  PubMed  Google Scholar 

  25. Guerreiro IM, Vieira C, Soares A, Braga A, Jácom M (2019) Case report management of locally advanced esthesioneuroblastoma in a pregnant woman. Case Rep Oncol Med 2019(Figure 1):1–6

    Google Scholar 

  26. Loy AH et al (2006) Continued follow-up of a single institution’s experience. Arch Otolaryngol Head Neck Surg 132:134–138

    Article  PubMed  Google Scholar 

  27. Jiang HZ et al (2011) Case report olfactory neuroblastoma treated by endoscopic surgery followed by combined external beam radiation and gamma knife for optic nerve and chiasm sparing: A case report. Case Rep Med 2011:10–12. https://doi.org/10.1155/2011/765645

    Article  Google Scholar 

  28. Wu J-Y, Chiou J-F, Ting L-L (2019) Chemo-radiotherapy for olfactory neuroblastoma: cases report and literature review. Ther Radiol Oncol 3:26–26. https://doi.org/10.21037/tro.2019.07.01

    Article  Google Scholar 

  29. Bisogno G, Soloni P, Conte M et al (2012) Esthesioneuroblastoma in pediatric and adolescent age. A report from the TREP project in cooperation with the Italian Neuroblastoma and Soft Tissue Sarcoma Committees. BMC Cancer 12:117. https://doi.org/10.1186/1471-2407-12-117

  30. Eich HT, Müller RP, Micke O, Kocher M, Berthold F, Hero B (2005) Esthesioneuroblastoma in childhood and adolescence: better prognosis with multimodal treatment? Strahlentherapie und Onkol 181(6):378–384. https://doi.org/10.1007/s00066-005-1362-2

    Article  Google Scholar 

  31. Pagella F et al (2017) ‘TuNa-saving’ endoscopic medial maxillectomy: a surgical technique for maxillary inverted papilloma. Eur Arch Oto-Rhino-Laryngology 274(7):2785–2791. https://doi.org/10.1007/s00405-017-4549-0

    Article  Google Scholar 

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  1. Department of E.N.T., Government Medical College and New Civil Hospital, Surat, India

    Kartika Ramesh Rao & Ila B. Upadhya

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  1. Kartika Ramesh Rao
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Correspondence to Kartika Ramesh Rao.

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Rao, K.R., Upadhya, I.B. A Review on Esthesioneuroblastoma. Indian J Otolaryngol Head Neck Surg 74 (Suppl 2), 1584–1590 (2022). https://doi.org/10.1007/s12070-021-02726-2

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