Abstract
Leiomyosarcoma and its pleomorphic variant are rare entities in the head and neck region. Since they usually present as slow growing, discrete firm, and non-ulcerated painless mass, they seem to be deceptively benign and are thus misdiagnosed. Histopathological and immunohistochemical studies are the ways of getting a definitive diagnosis. Till date surgery has been the primary treatment but effectiveness of radiotherapy/chemotherapy is still questionable. Here, we describe a case of leiomyosarcoma in mandible along with discussion about the ways of diagnosis, its differentiation with its pleomorphic variant and their managements.
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References
Yadav J, Bakshi J, Chouhan M, Modi R (2013) Head and neck leiomyosarcoma. Indian J Otolaryngol Head Neck Surg 65(1):1–5
Marx RE, Stern D (2003) Oral and maxillofacial pathology. Quintessence, Chicago
Guillou L (2008) Pleomorphic sarcomas: subclassification, myogenic differentiation and prognosis. Diagn Histopathol 14(11):527–537
Oda Y, Miyajima K, Kawaguchi KI, Tamiya S, Oshiro Y, Hachitanda Y, Oya M, Iwamoto Y, Tsuneyoshi M (2001) Pleomorphic leiomyosarcoma: clinicopathologic and immunohistochemical study with special emphasis on its distinction from ordinary leiomyosarcoma and malignant fibrous histiocytoma. Am J Surg Pathol 25(8):1030–1038
Patel K, French C, Khariwala SS, Rohrer M, Kademani D (2013) Intraosseous leiomyosarcoma of the mandible: a case report. J Oral Maxillofac Surg 71(7):1209–1216
Gokavarapu S, Kumar KJ, Chander R, Murthy S (2014) Leiomyosarcoma of oral cavity: rare presentation in retromolar trigone. Oral Sci Int 11(2):76–79
Marioni G, Bertino G, Mariuzzi L, Bergamin-Bracale AM, Lombardo M, Beltrami CA (2000) Laryngeal leiomyosarcoma. J Laryngol Otol 114(5):398–401
Eilber FR, Eckardt J (1997) Surgical management of soft tissue sarcomas. Semin Oncol 24:526–533
Nicolas MM, Tamboli P, Gomez JA, Czerniak BA (2010) Pleomorphic and dedifferentiated leiomyosarcoma: clinicopathologic and immunohistochemical study of 41 cases. Hum Pathol 41(5):663–671
Cipriani NA, Kurzawa P, Ahmad RA, Deshpande V, Hornicek FJ, Mullen JT, Nielsen GP (2014) Prognostic value of myogenic differentiation in undifferentiated pleomorphic sarcomas of soft tissue. Hum Pathol 45(7):1504–1508
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Bala, M., Ray, A. & Saraf, A. Leiomyosarcoma of Mandible: A Diagnostic Dilemma; Case Report and Review of Literature. Indian J Otolaryngol Head Neck Surg 71 (Suppl 1), 848–851 (2019). https://doi.org/10.1007/s12070-019-01584-3
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DOI: https://doi.org/10.1007/s12070-019-01584-3