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Role of Proton Pump Inhibitors in Laryngopharyngeal Reflux: Clinical Evaluation in a North Indian Population

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Abstract

There has been an escalation of patients presenting with symptoms of Laryngopharyngeal reflux disease (LPRD) in the otorhinolaryngology clinics due to life style and dietary changes. This study was undertaken to evaluate the effect of various proton pump inhibitors in the treatment of LPRD using Reflux symptom index (RSI) and Reflux finding score (RFS). This was a prospective study conducted from June 2016 to February 2017 with a total of 240 patients with symptoms and signs of LPR. The patients were divided into 5 groups. Each group was subjected to particular proton pump inhibitor. There were 124 males 116 females with a mean age 34.3 and rural to urban ratio being 11. After 3 months, RFS and RSI score within each group, improved significantly with Proton pump inhibitor therapy. In our study patients who were treated with omeprazole 20 mg twice daily had the highest improvement in laryngeal symptoms and laryngeal findings. We conclude emphasizing the effectiveness of proton pump inhibitors with incorporation of lifestyle modification in the successful management of LPRD.

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Authors and Affiliations

  1. Department of ENT, Era’s Lucknow Medical College and Hospital, Lucknow, India

    Anuja Bhargava, S. M. Faiz, Mrinal Ranjan Srivastava & Nafas Jeet Singh

  2. Department of Community Medicine, Era’s Lucknow Medical College and Hospital, Lucknow, India

    Mohammad Shakeel

Authors
  1. Anuja Bhargava
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  2. S. M. Faiz
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  3. Mrinal Ranjan Srivastava
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  4. Mohammad Shakeel
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  5. Nafas Jeet Singh
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Correspondence to Anuja Bhargava.

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All authors declare that they have no conflict of interest.

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Informed consent was obtained from all individual participants included in the study.

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All procedures performed involving human participants were in accordance wit h the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Bhargava, A., Faiz, S.M., Srivastava, M.R. et al. Role of Proton Pump Inhibitors in Laryngopharyngeal Reflux: Clinical Evaluation in a North Indian Population. Indian J Otolaryngol Head Neck Surg 71, 371–377 (2019). https://doi.org/10.1007/s12070-018-1493-2

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  • DOI: https://doi.org/10.1007/s12070-018-1493-2

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