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Audiological and Electrophysiological Changes in Patients with Vitiligo

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Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

The study was conducted to evaluate the audiological and electrophysiological findings in patients with Vitiligo and to compare the findings with otologically and audiologically normal controls. Study group included 50 subjects (25 Males, 25 Females) with Vitiligo (Mean age-27.4 years) and control group contained 40 age-matched normal hearing subjects. Pure tone audiometry (PTA) with extended high frequency audiometry, Otoacoustic emissions (OAEs), Tympanometry, Auditory brainstem responses (ABR) and Middle latency responses (MLR) were conducted in all subjects. Comparison of the study group with the control group showed statistically significant differences (p < 0.05) on PTA, in Transient otoacoustic emissions (TOAEs) at 1, 2, 3, 4 kHz and in distortion product otoacoustic emissions (DPOAEs) at 357, 499, 704, 1003 Hz. On ABR, statistically significant differences were observed between the groups in wave I (p < 0.01) in both ears, wave V (p < 0.05) in left ear and on interpeak latency of I–III (p < 0.01, p < 0.05), III–V (p < 0.01 in left ear) and I–V (p < 0.01, p < 0.05) in left and right ears respectively. When patients with localized vitiligo were compared with generalized vitiligo, the SNR of TOAEs was highly significant in both ears at 2 KHz (p < 0.05), 3 kHz (p < 0.01) and 4 kHz (p < 0.05). PTA average of 2 KHz, 4 and 8 kHz (PTA2) showed a significant difference (p < 0.01) when localized vitiligo was compared to generalized vitiligo. Results support possible auditory and electrophysiological changes in Vitiligo patients along with decreased cochlear function.

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Acknowledgments

We will like to acknowledge the co-operation by Dr. Kanwar, Dr. Shekhar (Department of Dermatology) and subjects who participated in the study for their constant co-operation.

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Authors and Affiliations

  1. Department of Otolaryngology, Guru Gobind Singh (GGS) Medical College and Hospital, BFUHS, Sadiq Road, Faridkot, Punjab, 151203, India

    Richa Arya

  2. Speech and Hearing Unit, Department of Otolaryngology, PGIMER, Chandigarh, 160012, India

    Sanjay Kumar Munjal

  3. Department of Otolaryngology, PGIMER, Chandigarh, 160012, India

    Naresh Kumar Panda

  4. Department of Dermatology, PGIMER, Chandigarh, 160012, India

    Davinder Prasad

Authors
  1. Richa Arya
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  2. Sanjay Kumar Munjal
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  3. Naresh Kumar Panda
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  4. Davinder Prasad
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Corresponding author

Correspondence to Richa Arya.

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Ethical Standards

All procedures performed were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments. Informed consent was obtained from all individual participants included in the study.

Conflict of interest

No conflict of interest as no funding was received from any agency. Richa Arya, Sanjay Munjal, Naresh Kumar Panda and Davinder Prasad declares that he/she has no conflict of interest.

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Arya, R., Kumar Munjal, S., Panda, N.K. et al. Audiological and Electrophysiological Changes in Patients with Vitiligo. Indian J Otolaryngol Head Neck Surg 68, 417–423 (2016). https://doi.org/10.1007/s12070-015-0889-5

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  • DOI: https://doi.org/10.1007/s12070-015-0889-5

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