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Current practice of saphenous vein graft harvesting in coronary artery bypass graft surgery: an Indian survey

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Indian Journal of Thoracic and Cardiovascular Surgery Aims and scope Submit manuscript

An Invited editorial to this article was published on 31 December 2022

Abstract

Purpose

The treatment of occluded saphenous vein graft (SVG) is challenging, and thus preventing the graft occlusion is of utmost importance. However, despite its recognized importance, a paucity of data exists regarding how SVGs are handled and preserved. Hence, this survey was conducted to document the techniques of vein graft preservation and handling among cardiac surgeons in India.

Methods

The survey had 26 questions regarding vein graft usage, harvesting, handling, and preservation techniques. Three hundred cardiac surgeons across India participated in this survey between March 2019 and July 2019.

Results

Responses were received from 215 (71.6%) surgeons across 13 states. Around 87% of respondents reported that ≥ 76% of veins were harvested by the open technique. Among the respondents, around 67% used one SVG in ≥ 96% of their patients, 45% used two SVGs in ≥ 86% of their patients, and 38% used ≥ 3 SVGs in < 25% of their patients, respectively. Around 54%, 27%, 9%, and 9% of respondents used autologous whole blood, saline solution, pH-buffered solution, and other solutions, respectively. In addition, 96.74% of respondents heparinized their vein graft preservation solutions, and 98.14% preserved the solution at room temperature. 34.88% and 83.26% of respondents used dual antiplatelet therapy (DAPT) before and after surgery in ≥ 76% of their patients, respectively. 63.26% of the surgeons reported that the patients received DAPT for > 12 months.

Conclusion

There is a significant variance in the process of vein harvesting, preservation, handling, and antiplatelet therapy protocols among various cardiac surgeons across India. Therefore, there is a need for standardization in the practice of vein harvesting.

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References

  1. Sreeniwas Kumar A, Sinha N. Cardiovascular disease in India: a 360 degree overview. Med J Armed Forces India. 2020;76:1–3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Fihn SD, Blankenship JC, Alexander KP, et al. 2014 ACC/AHA/AATS/PCNA/SCAI/STS focused update of the guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines, and the American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. J Am Coll Cardiol. 2014;64:1929–49.

    Article  PubMed  Google Scholar 

  3. Neumann F-J, Sousa-Uva M, Ahlsson A, et al. 2018 ESC/EACTS Guidelines on myocardial revascularization. Eur Heart J. 2019;40:87–165.

    Article  PubMed  Google Scholar 

  4. Aldea GS, Bakaeen FG, Pal J, et al. The Society of Thoracic Surgeons Clinical Practice Guidelines on Arterial Conduits for Coronary Artery Bypass Grafting. Ann Thorac Surg. 2016;101:801–9.

    Article  PubMed  Google Scholar 

  5. Raza S, Chang C, Deo SV, Sabik JF 3rd. Current role of saphenous vein graft in coronary artery bypass grafting. Indian J Thorac Cardiovasc Surg. 2018;34:245–50.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Caliskan E, de Souza DR, Böning A, et al. Saphenous vein grafts in contemporary coronary artery bypass graft surgery. Nat Rev Cardiol. 2020;17:155–69.

    Article  CAS  PubMed  Google Scholar 

  7. Goldman S, Zadina K, Moritz T, et al. Long-term patency of saphenous vein and left internal mammary artery grafts after coronary artery bypass surgery: resultsfrom a Department of Veterans Affairs Cooperative Study. J Am Coll Cardiol. 2004;44:2149–56.

    Article  PubMed  Google Scholar 

  8. Samano N, Geijer H, Liden M, Fremes S, Bodin L, Souza D. The no-touch saphenous vein for coronary artery bypass grafting maintains a patency, after 16 years, comparable to the left internal thoracic artery: A randomized trial. J Thorac Cardiovasc Surg. 2015;150:880–8.

    Article  PubMed  Google Scholar 

  9. Gundry SR, Jones M, Ishihara T, Ferrans VJ. Optimal preparation techniques for human saphenous vein grafts. Surgery. 1980;88:785–94.

    CAS  PubMed  Google Scholar 

  10. Deo SV, Dunlay SM, Shah IK, et al. Dual anti-platelet therapy after coronary artery bypass grafting: is there any benefit? A systematic review and meta-analysis. J Card Surg. 2013;28:109–16.

    Article  PubMed  Google Scholar 

  11. Wolf RK, Falk V. Intraoperative assessment of coronary artery bypass grafts. J Thorac Cardiovasc Surg. 2003;126:634–7.

    Article  PubMed  Google Scholar 

  12. Taggart DP, Benedetto U, Gerry S, et al. Bilateral versus Single Internal-Thoracic-Artery Grafts at 10 Years. N Engl J Med. 2019;380:437–46.

    Article  PubMed  Google Scholar 

  13. Gaudino M, Tondi P, Benedetto U, et al. Radial artery as a coronary artery bypass conduit: 20-year results. J Am Coll Cardiol. 2016;68:603–10.

    Article  PubMed  Google Scholar 

  14. Muneretto C, Bisleri G, Negri A, et al. Total arterial myocardial revascularization with composite grafts improves results of coronary surgery in elderly: a prospective randomized comparison with conventional coronary artery bypass surgery. Circulation. 2003;108:II29–33

  15. Ruttmann E, Fischler N, Sakic A, et al. Second internal thoracic artery versus radial artery in coronary artery bypass grafting: a long-term, propensity score-matched follow-up study. Circulation. 2011;124:1321–9.

    Article  PubMed  Google Scholar 

  16. Suma H. Gastroepiploic artery graft in coronary artery bypass grafting. Ann Cardiothorac Surg. 2013;2:493–8.

    PubMed  PubMed Central  Google Scholar 

  17. Williams JB, Harskamp RE, Bose S, et al. The preservation and handling of vein grafts in current surgical practice: findings of a survey among cardiovascular surgeons of top-ranked US hospitals. JAMA Surg. 2015;150:681–3.

    Article  PubMed  Google Scholar 

  18. Dacey LJ. Endoscopic vein-graft harvest is safe for CABG surgery. JAMA. 2012;308:512–3.

    Article  CAS  PubMed  Google Scholar 

  19. Lopes RD, Hafley GE, Allen KB, et al. Endoscopic versus open vein-graft harvesting in coronary-artery bypass surgery. N Engl J Med. 2009;361:235–44.

    Article  CAS  PubMed  Google Scholar 

  20. Zenati MA, Shroyer AL, Collins JF, et al. Impact of endoscopic versus open saphenous vein harvest technique on late coronary artery bypass grafting patient outcomes in the ROOBY (Randomized On/Off Bypass) Trial. J Thorac Cardiovasc Surg. 2011;141:338–44.

    Article  PubMed  Google Scholar 

  21. Lumsden AB, Eaves FF 3rd, Ofenloch JC, Jordan WD. Subcutaneous, video-assisted saphenous vein harvest: report of the first 30 cases. Cardiovasc Surg. 1996;4:771–6.

    Article  CAS  PubMed  Google Scholar 

  22. Dacey LJ, Braxton JH Jr, Kramer RS, et al. Long-term outcomes of endoscopic vein harvesting after coronary artery bypass grafting. Circulation. 2011;123:147–53.

    Article  PubMed  Google Scholar 

  23. Soni MK, Williams L, Raja SG. Use of endoscopic vein harvesting (EVH) during coronary artery bypass grafting in United Kingdom: the EVH survey. Int J Surg. 2019;69:146–51.

    Article  PubMed  Google Scholar 

  24. Lawrie GM, Weilbacher DE, Henry PD. Endothelium-dependent relaxation in human saphenous vein grafts. Effects of preparation and clinicopathologic correlations. J Thorac Cardiovasc Surg. 1990;100:612–20.

  25. Lamm P, Juchem G, Milz S, Reichart B. Continuous graft perfusion: optimizing the quality of saphenous vein grafts. Heart Surg Forum. 2002;5:S355-61.

    PubMed  Google Scholar 

  26. Zerkowski HR, Knocks M, Konerding MA, et al. Endothelial damage of the venous graft in CABG. Influence of solutions used for storage and rinsing on endothelial function. Eur J Cardiothorac Surg. 1993; 7: 376–82.

  27. Chester AH, O’Neil GS, Tadjakarimi S, Borland JA, Yacoub MH. Effect of peri-operative storage solution on the vascular reactivity of the human saphenous vein. Eur J Cardiothorac Surg. 1993;7:399–404.

    Article  CAS  PubMed  Google Scholar 

  28. Catinella FP, Cunningham JN Jr, Srungaram RK, et al. The factors influencing early patency of coronary artery bypass vein grafts: correlation of angiographic and ultrastructural findings. J Thorac Cardiovasc Surg. 1982;83:686–700.

    Article  CAS  PubMed  Google Scholar 

  29. Santoli E, Di Mattia D, Boldorini R, Mingoli A, Tosoni A, Santoli C. University of Wisconsin solution and human saphenous vein graft preservation: preliminary anatomic report. Eur J Cardiothorac Surg. 1993;7:548–52.

    Article  CAS  PubMed  Google Scholar 

  30. Kulik A, Ruel M, Jneid H, et al. Secondary prevention after coronary artery bypass graft surgery: a scientific statement from the American Heart Association. Circulation. 2015;131:927–64.

    Article  PubMed  Google Scholar 

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Correspondence to Lokeswara Rao Sajja.

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Ethical committee approval

This study complies with the principles of the Declaration of Helsinki and was approved by the institutional ethics committee dated 29 Oct. 2022 with the reference no.: SH/RS/IEC/2021– 2022/1012.

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The authors declare that there is no conflict of interest.

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The need for informed consent from the patient was waived off as this study does not involve patients’ participation.

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Sajja, L.R., Kamtam, D.N., Sreeramula, S.K. et al. Current practice of saphenous vein graft harvesting in coronary artery bypass graft surgery: an Indian survey. Indian J Thorac Cardiovasc Surg 39, 115–124 (2023). https://doi.org/10.1007/s12055-022-01441-z

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