Abstract
In this study, we examined and validated how common variants contribute to susceptibility to chronic obstructive pulmonary disease (COPD) in the Han Chinese population. Here, we genotyped 18 nucleotide polymorphisms and evaluated their association with COPD using chi-square test and genetic model analysis (246 COPD patients and 350 controls), and found three SNPs that might cause a predisposition to COPD. Both rs3025030 and rs3025033 are located on chromosome 6 in VEGF-A. We found one risk allele ‘C’ from rs3025030 and another ‘G’ from rs3025033 using the log-additive model (OR 1.40; 95% CI 1.05–5.96; P = 0.022), (OR 1.38; 95% CI 1.03–1.84; P = 0.03). We also found another risk allele ‘A’ of rs9296092 in gene region ZBTB9-BAK1 by the allele model (OR 2.63; 95% CI 1.27–5.45; P = 0.0078), (adjusted OR 3.53; 95% CI 1.12–11.11; P = 0.031). We found a risk haplotype ‘CG’ associated with the risk of COPD (OR 1.39; 95% CI 1.04–1.86; P=0.028). Our results when compared with previous studies showed significant association between VEGF-A polymorphism and COPD. We also identified rs9296092 as a risk factor for COPD.
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Acknowledgements
This work was supported by the National Natural Science Foundation of China (no. 81160008). It is our great honour to express heartfelt thanks to all the patients and individuals for their participation. We are grateful to the clinicians and other hospital staff who contributed to the blood samples and data collection for this study.
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Ding Y., Niu H., Li Y., He P., Li Q., Ouyang Y., Li M., Hu Z., Zhong Y., Sun P. and Jin T. 2016 Polymorphisms in VEGF-Aare associated with COPD risk in the Chinese population from Hainan province. J. Genet. 95, xx–xx
Yipeng Ding and Huan Niu contributed equally to this work.
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DING, Y., NIU, H., LI, Y. et al. Polymorphisms in VEGF-A are associated with COPD risk in the Chinese population from Hainan province. J Genet 95, 151–156 (2016). https://doi.org/10.1007/s12041-016-0627-0
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DOI: https://doi.org/10.1007/s12041-016-0627-0