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Metal-free, an effective and one-pot protocol for the reductive amination of aldehydes using glycerol as a green solvent

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Abstract

A novel, green, catalyst-free, and efficient method has been developed for the one-pot reductive amination of carbonyl compounds using sodium borohydride. This method has performed reductive amination on various functionalized amines and aldehydes, including aliphatic, aromatic, and heteroaromatic compounds. The reductive amination of the carbonyl compounds occurred in a single step without any side reaction. The key benefits of this technique included its easiness, greener protocol, quick transformation, variety of substrates, high yield, metal-free, and solvent recyclability. This helps to make the procedure practical, affordable, and biodegradable.

Graphical abstract

A novel, green, catalyst-free, and efficient method has been developed for one-pot reductive amination of carbonyl compounds using sodium borohydride. This method has performed reductive amination on various functionalized amines and aldehydes, including aliphatic, aromatic, and hetero-aromatic ones. The reductive amination of the carbonyl compounds occurred in a single step without any side reaction. The key benefits of this technique included its easiness, greener protocol, quick transformation, variety of substrates, outstanding yield, metal-free, and solvent recyclability. This helps to make the procedure practical, affordable, and biodegradable. In this work, we studied electron-donating, electron-withdrawing, aliphatic, heterocyclic, and chiral amines used in the reaction.

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Acknowledgements

We thank the Department of Chemistry, School of Chemical Engineering and Physical Science, Lovely Professional University, Phagwara-144411, Punjab, India. The authors, Shripad M. Patil and Ashwini Bedre thank the Principal, Dada Patil Mahavidyalaya, Karjat, for supporting this research work financially (Seed money project 2022). The author Vilas B Gade thanks the Principal, Arts, Science and Commerce College, Mokhada, Dist: Palghar, for providing constant support and encouragement.

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Authors and Affiliations

  1. School of Chemical Engineering and Physical Science, Lovely Professional University, Phagwara, Punjab, 144 411, India

    Shripad M Patil

  2. Savitribai Phule Pune University, Dada Patil Mahavidyalaya, Karjat, Maharashtra, 414 401, India

    Shripad M Patil & Ashwini V Bedre

  3. Department of Chemistry, Rayat Shikshan Sanstha’s, Arts, Science and Commerce College, Mokhada, Palghar, Maharashtra, 401 604, India

    Vilas B Gade

  4. Department of Chemistry, M. V. P. Samaj’s, Arts, Commerce and Science College, Tryambakeshwar, Nashik, Maharashtra, 422 212, India

    Manohar K Jopale

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  1. Shripad M Patil
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Patil, S.M., Bedre, A.V., Gade, V.B. et al. Metal-free, an effective and one-pot protocol for the reductive amination of aldehydes using glycerol as a green solvent. J Chem Sci 135, 50 (2023). https://doi.org/10.1007/s12039-023-02172-3

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  • DOI: https://doi.org/10.1007/s12039-023-02172-3

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