Abstract
One-pot synthesis of isoindole fused quinazolin 4-ones via intramolecular 1,3 hydride transfer in the presence of acid catalyst has been described. Substrate scope and mechanistic insights were investigated. Substituents on the amide side have a negligible influence on the key step and therefore the method have wide scope for accessing various bicyclic core structure.
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Acknowledgements
Authors are thankful to the SERB New Delhi, (EMR/2014/000542) and Jadavpur University, Kolkata for financial support. Special thanks to Dr. P. Mahata, Department of Chemistry, JU for his kind support for solving crystal structure.
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Mondal, M.A., Mondal, S. & Khan, A.A. A mechanistic insight into the acid catalyzed, one-pot synthesis of isoindole-fused quinazolin 4-ones. J Chem Sci 132, 63 (2020). https://doi.org/10.1007/s12039-020-01768-3
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DOI: https://doi.org/10.1007/s12039-020-01768-3