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A review on transition-metal mediated synthesis of quinolines

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Abstract

Quinoline is one of the important class of heterocyclic compounds which have gained considerable importance because of its high pharmaceutical efficacy and broad range of biological activities such as anti-cancer, anti-malarial, anti-microbial and anti-asthmatic. As a consequence, the desire for new versatile and efficient route for the synthesis of quinoline scaffolds remains an active and growing area of interest both in academia and industry. However, developments of transition-metal catalyzed synthetic methods have witnessed a dominant position over the past few years for the synthesis of diverse range of complex heterocyclics containing quinoline scaffolds. This review specifically provides an overview of the literature available on the transition–metal catalyzed synthetic methodologies for the synthesis of polysubstituted quinoline derivatives.

Graphical Abstract

Synopsis This review presents a systematic and comprehensive literature survey on the transition metal catalyzed synthesis of polysubstituted quinolines: A versatile building block of several biologically significant heterocycles and natural products.

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Acknowledgements

R. S. thanks SMVD University for fellowship.

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Authors and Affiliations

  1. Synthetic Organic Chemistry Lab., Faculty of Sciences, Shri Mata Vaishno Devi University, Katra, Jammu and Kashmir, 182 320, India

    Rashmi Sharma, Parteek Kour & Anil Kumar

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  1. Rashmi Sharma
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  2. Parteek Kour
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  3. Anil Kumar
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Correspondence to Anil Kumar.

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Special Section on Transition Metal Catalyzed Synthesis of Medicinally Relevant Molecules

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Sharma, R., Kour, P. & Kumar, A. A review on transition-metal mediated synthesis of quinolines. J Chem Sci 130, 73 (2018). https://doi.org/10.1007/s12039-018-1466-8

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