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Synthesis and phosphatase activity of a Cobalt(II) phenanthroline complex

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Abstract

A mononuclear cobalt(II) complex, [\(\hbox {Co}\hbox {(phen)}_{2}\hbox {Cl}_{2}\)], (phen = 1,10-phenanthroline) has been synthesized and structurally characterized by different spectroscopic methods including single crystal X-ray structural study. X-ray crystal structural analysis revealed that the cobalt(II) complex crystallizes in a monoclinic system with C2 / c space group and exists in cis-configuration in its crystalline state. Room temperature magnetic measurement accounts for 3e paramagnetism and indicates high spin cobalt(II) in the solid state. The cobalt(II) complex has been evaluated as a functional model for phosphatase enzyme by using 4-nitrophenylphosphate (PNPP) as a standard substrate in aqueous DMF medium. This mononuclear cobalt(II) complex exhibits good hydrolytic phosphoester cleavage efficiency with \(k_{\mathrm{cat}}\) value of \(3.78\times 10^{2}\hbox {h}^{-1}\).

Graphical Abstract

SYNOPSIS The cobalt(II) complex of phenanthroline exhibits good catalytic activity towards 4-nitrophenylphosphate (PNPP) as a standard substrate in aqueous DMF medium with \(k_{\mathrm{cat}}\) value of \(3.78\times 10^{2} \hbox { h}^{-1}\).

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Acknowledgements

BB gratefully acknowledges the Science & Engineering Research Board (SERB), a statutory body under Department of Science and Technology (DST), New Delhi for financial support under the FAST TRACK SCHEME for YOUNG SCIENTIST (No. SB/FT/CS-088/2013 dtd. 21/05/2014). ARC and HRY thank IISER Mohali for XtaLab mini diffractometer facility. HRY thanks IISER Mohali for senior research fellowship. This research work is dedicated to Dr. Pradeepta Guptaray, Principal, Dum Dum Motijheel College, Kolkata 700 074, West Bengal, India for remaining a constant source of inspiration.

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  1. Bhaskar Biswas

    Present address: Department of Chemistry, Surendranath College, 24/2 Mahatma Gandhi Road, Kolkata, West Bengal, 700 009, India

Authors and Affiliations

  1. Department of Chemistry, Raghunathpur College, Purulia, West Bengal, 723 133, India

    Mamoni Garai, Dhananjay Dey & Bhaskar Biswas

  2. Department of Chemical Sciences, Indian Institute of Science Education and Research Mohali, Sector 81, S. A. S. Nagar, Manauli, P.O., Mohali, Punjab, 140 306, India

    Hare Ram Yadav & Angshuman Roy Choudhury

  3. Department of Chemistry, National Institute of Technology, Mahatma Gandhi Avenue, Durgapur, West Bengal, 713 209, India

    Milan Maji

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Garai, M., Dey, D., Yadav, H.R. et al. Synthesis and phosphatase activity of a Cobalt(II) phenanthroline complex. J Chem Sci 129, 1513–1520 (2017). https://doi.org/10.1007/s12039-017-1355-6

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