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Transcriptomic Analysis Reveals Sex-Dependent Expression Patterns in the Basolateral Amygdala of Dominant and Subordinate Animals After Acute Social Conflict

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Abstract

The basolateral amygdala (BLA) is a critical nucleus mediating behavioral responses after exposure to acute social conflict. Male and female Syrian hamsters both readily establish a stable dominant-subordinate relationship among same-sex conspecifics, and the goal of the current study was to determine potential underlying genetic mechanisms in the BLA facilitating the establishment of social hierarchy. We sequenced the BLA transcriptomes of dominant, subordinate, and socially neutral males and females, and using de novo assembly techniques and gene network analyses, we compared these transcriptomes across social status within each sex. Our results revealed 499 transcripts that were differentially expressed in the BLA across both males and females and 138 distinct gene networks. Surprisingly, we found that there was virtually no overlap in the transcript changes or in gene network patterns in males and females of the same social status. These results suggest that, although males and females reliably engage in similar social behaviors to establish social dominance, the molecular mechanisms in the BLA by which these statuses are obtained and maintained are distinct.

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Acknowledgements

The authors gratefully acknowledge Dr. James C. Walton, Alisa Norvelle, M.S., and Georgia State University’s Research Solutions and High Performance Computing Group for their expert assistance. The authors would also like to thank Reed A. Gilbert, Atit A. Patel, and Dr. Brittany M. Thompson for their technical assistance. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or Georgia State University.

Funding

This project was supported by NIH RO1MH062044 to KLH, Georgia State University Brains and Behavior Seed Grant to KLH, Georgia State University Dissertation Grant to KEM, Brains and Behavior Fellowships to KEM, DMS, and AMR, Honeycutt Fellowships to KEM and AMR, and a Next Generation Postdoctoral Fellowship from the Center for Behavioral Neuroscience to LQB.

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  1. Neuroscience Institute, Georgia State University, 161 Jesse Hill Jr. Drive, Atlanta, GA, 30303, USA

    Katharine E. McCann, David M. Sinkiewicz, Anna M. Rosenhauer, Linda Q. Beach & Kim L. Huhman

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  1. Katharine E. McCann
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  2. David M. Sinkiewicz
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Correspondence to Kim L. Huhman.

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All procedures and protocols were approved by the Georgia State University Institutional Animal Care and Use Committee and are in accordance with the standards outlined in the National Institutes of Health Guide for Care and Use of Laboratory Animals.

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McCann, K.E., Sinkiewicz, D.M., Rosenhauer, A.M. et al. Transcriptomic Analysis Reveals Sex-Dependent Expression Patterns in the Basolateral Amygdala of Dominant and Subordinate Animals After Acute Social Conflict. Mol Neurobiol 56, 3768–3779 (2019). https://doi.org/10.1007/s12035-018-1339-7

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