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Transplantation of Human Chorion-Derived Cholinergic Progenitor Cells: a Novel Treatment for Neurological Disorders

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A Correction to this article was published on 26 April 2018

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Abstract

A neurological disorder is any disorder or abnormality in the nervous system. Among different neurological disorders, Alzheimer’s disease (AD) is recognized as the sixth leading cause of death globally. Considerable research has been conducted to find pioneer treatments for this devastating disorder among which cell therapy has attracted remarkable attentions over the last decade. Up to now, targeted differentiation into specific desirable cell types has remained a major obstacle to clinical application of cell therapy. Also, potential risks including uncontrolled growth of stem cells could be disastrous. In our novel protocol, we used basal forebrain cholinergic progenitor cells (BFCN) derived from human chorion-derived mesenchymal stem cells (hC-MSCs) which made it possible to obtain high-quality population of cholinergic neurons and in vivo in much shorter time period than previous established methods. Remarkably, the transplanted progenitors fully differentiated to cholinergic neurons which in turn integrated in higher cortical networks of host brains, resulting in significant improvement in cognitive assessments. This method may have profound implications in cell therapies for any other neurodegenerative disorders.

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  • 26 April 2018

    The original version of this article unfortunately contained mistake in the affiliation. Affiliation 1 should be read as “Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran”. The original article has been corrected.

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Acknowledgements

This work was carried out within the framework of a collaborative project (Project Grant No. 94-02-30-25922) by the School of Medicine, Iran University of Medical Sciences, (Project Grant No. REP209) council for stem cell sciences and technologies (Presidency of the Islamic Republic of Iran, vice-presidency for science and technology), and Iran National Science Foundation (INSF).

Author information

Author notes

  1. Alireza Mohammadi and Ali Maleki-Jamshid contributed equally to this work.

Authors and Affiliations

  1. Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

    Alireza Mohammadi

  2. Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

    Ali Maleki-Jamshid, Mansoureh Soleimani, Mehrdad Bakhtiari & Mohammad Taghi Joghataei

  3. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran

    Ali Maleki-Jamshid, Peiman Brouki Milan, Arash Rahmani, Mansoureh Soleimani, Mehrdad Bakhtiari, Faezeh Faghihi, Mohammad Taghi Joghataei & Masoud Mozafari

  4. Department of Neuroscience, School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran

    Ali Maleki-Jamshid & Mohammad Taghi Joghataei

  5. Department of Genetics, Faculty of Biological Sciences, Shahid Beheshti University, Tehran, Iran

    Davood Sanooghi

  6. Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran

    Peiman Brouki Milan & Masoud Mozafari

  7. Mental Health Research Center, Tehran Institute of Psychiatry- School of Behavioral and Sciences Mental Health, Iran University of Medical Sciences, Tehran, Iran

    Arash Rahmani

  8. School of Engineering, Design and Technology-Medical Engineering, University of Bradford, Bradford, West Yorkshire, UK

    Farshid Sefat

  9. Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran

    Koorosh Shahpasand

  10. Physiology Research Center and Department of Physiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran

    Rafie Belali

  11. Neurosciences Institute and Department of Biology, College of Sciences, University of Texas at San Antonio, San Antonio, TX, USA

    George Perry

  12. Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), PO Box 14155-4777, Tehran, Iran

    Masoud Mozafari

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  1. Alireza Mohammadi
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  2. Ali Maleki-Jamshid
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Corresponding authors

Correspondence to Faezeh Faghihi, Mohammad Taghi Joghataei, George Perry or Masoud Mozafari.

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The authors declare that they have no conflict of interest.

Additional information

The original version of this article was revised: Affiliation 1 should be read as “Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran”.

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Mohammadi, A., Maleki-Jamshid, A., Sanooghi, D. et al. Transplantation of Human Chorion-Derived Cholinergic Progenitor Cells: a Novel Treatment for Neurological Disorders. Mol Neurobiol 56, 307–318 (2019). https://doi.org/10.1007/s12035-018-0968-1

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