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Neuronal Activity-Induced Sterol Regulatory Element Binding Protein-1 (SREBP1) is Disrupted in Dysbindin-Null Mice—Potential Link to Cognitive Impairment in Schizophrenia

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Abstract

Schizophrenia is a chronic debilitating neuropsychiatric disorder that affects about 1 % of the population. Dystrobrevin-binding protein 1 (DTNBP1 or dysbindin) is one of the Research Domain Constructs (RDoC) associated with cognition and is significantly reduced in the brain of schizophrenia patients. To further understand the molecular underpinnings of pathogenesis of schizophrenia, we have performed microarray analyses of the hippocampi from dysbindin knockout mice, and found that genes involved in the lipogenic pathway are suppressed. Moreover, we discovered that maturation of a master transcriptional regulator for lipid synthesis, sterol regulatory element binding protein-1 (SREBP1) is induced by neuronal activity, and is required for induction of the immediate early gene ARC (activity-regulated cytoskeleton-associated protein), necessary for synaptic plasticity and memory. We found that nuclear SREBP1 is dramatically reduced in dysbindin-1 knockout mice and postmortem brain tissues from human patients with schizophrenia. Furthermore, activity-dependent maturation of SREBP1 as well as ARC expression were attenuated in dysbindin-1 knockout mice, and these deficits were restored by an atypical antipsychotic drug, clozapine. Together, results indicate an important role of dysbindin-1 in neuronal activity induced SREBP1 and ARC, which could be related to cognitive deficits in schizophrenia.

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Acknowledgments

We thank Ms. Hui-Jen Lye and Ms. Sau-Yeen Loke for help with microarray analyses. This work was supported by the National Research Foundation, National Medical Research Council and National University Health System, Singapore (WYO) and by HD026979, MH079614, and DK084336 (SFK).

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Authors and Affiliations

  1. Department of Psychiatry, Center for Neurobiology and Behavior, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA

    Yong Chen, Sookhee Bang, Mary F. McMullen, Hala Kazi, Konrad Talbot, Greg Carlson, Steven E. Arnold & Sangwon F. Kim

  2. Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA

    Sangwon F. Kim

  3. Department of Anatomy and Neurobiology Research Programme, National University of Singapore, Singapore, 119260, Singapore

    Mei-Xuan Ho & Wei-Yi Ong

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  1. Yong Chen
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Chen, Y., Bang, S., McMullen, M.F. et al. Neuronal Activity-Induced Sterol Regulatory Element Binding Protein-1 (SREBP1) is Disrupted in Dysbindin-Null Mice—Potential Link to Cognitive Impairment in Schizophrenia. Mol Neurobiol 54, 1699–1709 (2017). https://doi.org/10.1007/s12035-016-9773-x

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