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RETRACTED ARTICLE: The Clinical Implications of Human Telomerase Reverse Transcriptase Expression in Grade and Prognosis of Gliomas: a Systematic Review and Meta-analysis

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This article was retracted on 12 May 2017

Abstract

Human telomerase reverse transcriptase (hTERT), a ribonucleoprotein, is reported as an important complex, which is required for stability of DNA molecular structure at the rear of the chromosome. Until now, hTERT has been linked to cell immortalization and tumorigenesis. A couple of articles have been published about the telomerase function in the gliomas; however, these results are conflicting in some degree. Thus, it is crucial to perform a meta-analysis to identify their real actions. We included eligible articles, and estimated odds ratios (ORs) with 95 % confidence intervals (95 % CIs). In our meta-analysis, all 15 eligible articles included 932 patients. Results from 10 studies on WHO grade showed that high hTERT gene or protein expression in glioma tissues was obviously related to high WHO grade (III + IV) (OR 2.45, 95 % CI 1.92–3.13; p = 0.000). What is more, hTERT expression was not associated with old age (OR 0.91, 95 % CI 0.72–1.16; p = 0.448) as well as gender (OR 1.06, 95 % CI 0.82–1.37; p = 0.664). Importantly, hTERT expression was significantly associated with 5-year overall survival (OS; n = 3; hazard ratio (HR) 2.25, 95 % CI 1.36–3.70; p = 0.002) of glioma patients. No heterogeneity was found in all studies. In conclusion, this meta-analysis suggests that hTERT is significantly associated with high glioma grade and poor 5-year overall survival, and pathological test of hTERT mRNA and protein in glioma tissues should be suggested as criteria of glioma grade in the clinical practice.

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Acknowledgments

This study was supported by Science and Technology Project of Shandong Province Academy of Medical Sciences (2013015). We greatly thank other members in Yang Lab for valuable suggestions and writing.

Conflict of Interest

The authors state that there are no conflicts of interest to disclose.

Ethical Statement

This study was granted by the Ethical Committee of Shandong Academy of Medical Sciences.

Author information

Authors and Affiliations

  1. Dean’s Office, Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan, Shandong, China

    Jing Li & Bin Feng

  2. Department of Special Inspection, Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan, Shandong, China

    Huiying Li

  3. The Sixth Department of Intern Medicine, Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan, Shandong, China

    Jihong Liu

  4. Department of Pathology, Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan, Shandong, China

    Man Feng & Xiangshan Yang

  5. Department of Nursing, Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan, Shandong, China

    Baoyu Lv

  6. Department of Gynecology, Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan, Shandong, China

    Shaomei Cheng

Authors
  1. Jing Li
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  2. Huiying Li
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  3. Jihong Liu
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  4. Bin Feng
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  5. Man Feng
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  7. Shaomei Cheng
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  8. Xiangshan Yang
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Corresponding author

Correspondence to Xiangshan Yang.

Additional information

This article has been retracted at the request of the Editor-in-Chief and the Publisher per the Committee on Publication Ethics guidelines. There is strong reason to believe that the peer review process was compromised and the authors have plagiarized parts from various articles.

An erratum to this article is available at http://dx.doi.org/10.1007/s12035-017-0603-6.

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Li, J., Li, H., Liu, J. et al. RETRACTED ARTICLE: The Clinical Implications of Human Telomerase Reverse Transcriptase Expression in Grade and Prognosis of Gliomas: a Systematic Review and Meta-analysis. Mol Neurobiol 53, 2887–2893 (2016). https://doi.org/10.1007/s12035-015-9170-x

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  • DOI: https://doi.org/10.1007/s12035-015-9170-x

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