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Polyacrylic-conjugated polyamidoamine G4.0 dendrimer as a potential nanocarrier for effective delivery of cisplatin

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Abstract

Platinum complexes have paid much attention to develop new drugs for cancer therapy due to its inhibitory activity against cancerous cell growth. In the study, the strategically programming cationic PAMAM G4.0 with carboxylate motifs was introduced as a delivery platform for cisplatin. Partial amino groups on the surface of PAMAM G4.0 had coupled with active carboxylate groups on polyacrylic acid (PAA) in order to reduce the remaining problem of cationic dendrimer and improve delivery effectiveness of aquated cisplatin. Our results show that the full cationic PAMAM G4.0 was toxic against both breast cancer (MCF7) and human dermal fibroblast (HuDF) cell lines at 100 ppm concentration. In the contract, the PAA-conjugated PAMAM G4.0 significantly improved their cytocompatibility of the cationic dendrimer. In addition, the modified PAMAM dendrimers G4.0 showed high affinity with the aquated cisplatin due to the presence of abundant carboxylic groups. Notably, the aquated cisplatin-complexed PAA-G4.0 showed 2.94-folded reduction in the toxicity against NCI H460 in comparison to free cisplatin drugs. Hence, the G4.0-PAA/aquated cisplatin nano-complex may become a promising versatile strategy for improving antitumour efficacy and reducing the side effects of platinum-based drugs.

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Acknowledgements

This research was funded by Thu Dau Mot University, under grant number 487/HD-NCKHPTCN. We are grateful to the group of Department of Genetics, Faculty of Biology, University of Science, for providing cancer cell line (MCF7 cells and NCI H460 cells) and human fibroblast cells (HuDF).

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Authors and Affiliations

  1. German Vietnamese Technology Center, HCMC University of Food Industry, Ho Chi Minh City, 700000, Vietnam

    Ngoc Hoa Nguyen

  2. Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Ho Chi Minh City, 700000, Vietnam

    Ngoc Hoa Nguyen, Le Hang Dang, Cuu Khoa Nguyen & Ngoc Quyen Tran

  3. Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City, 700000, Vietnam

    Le Hang Dang, Phuong Doan, Cuu Khoa Nguyen & Ngoc Quyen Tran

  4. School of Biomedical Engineering, International University, National Universities in HCMC, HCMC, 700000, Vietnam

    Chan Khon Huynh & Ngoc Quyen Tran

  5. Department of Natural Science, Thu Dau Mot University, Thu Dau Mot, Binh Duong Province, Vietnam

    Bich Tram Nguyen

  6. Center for Research and Technology Transfer, Vietnam Academy of Science and Technology, Hanoi, Vietnam

    Ngoc Tung Nguyen

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  1. Ngoc Hoa Nguyen
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  2. Le Hang Dang
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Correspondence to Ngoc Quyen Tran.

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Nguyen, N.H., Dang, L.H., Doan, P. et al. Polyacrylic-conjugated polyamidoamine G4.0 dendrimer as a potential nanocarrier for effective delivery of cisplatin. Bull Mater Sci 44, 87 (2021). https://doi.org/10.1007/s12034-021-02382-w

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  • DOI: https://doi.org/10.1007/s12034-021-02382-w

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