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Stealth cross-linked polymeric nanoparticles for passive drug targeting: a combination of molecular docking and comprehensive in vitro assay

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Abstract

Till date, several studies have reported magnetic drug targeting as well as passive drug delivery. In this study, the passive characteristic of PEGylated carriers with a neutral surface charge rather than chitosan (CS)-based nanoparticles (NPs) with a positive charge was proved using molecular docking. The complete and without flaw stealth CS-coated magnetic NPs (mNPs) loaded with an anticancer drug for intravenous drug delivery were prepared using a modified ionic-crosslinking method. The physicochemical properties of the prepared magnetic-CS NPs were characterized in detail. The transmission electron micrographs of NPs showed an uniform particle morphology with an average diameter of smaller than 10 nm. The average IC50 values of the drug in PEGylated NPs for MCF-7 and PC-12 cells were 44 and 72 µM, respectively. The fabricated stealth NPs can increase the cytotoxicity and cell permeability of formulation that may release the entire drug in targeted shape to objective tissues that were firstly proved by molecular docking. This strategy showed a reduction in uptaking of mNPs by the reticuloendothelial system, which indeed increases the concentration of therapeutic agent(s) in the target site.

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Acknowledgements

We express our sincere thanks to the deputy of Iran National Science Foundation (INSF) of the presidency of the Islamic Republic of Iran, vice presidency for science and technology under the Project 91003523.

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Authors and Affiliations

  1. Department of Applied Chemistry, Faculty of Chemistry, Razi University, Kermanshah, 6714414971, Iran

    ABBAS HEMATI AZANDARYANI & SOHEILA KASHANIAN

  2. Nano Drug Delivery Research Center, Kermanshah University of Medical Sciences, Kermanshah, 6715847141, Iran

    ABBAS HEMATI AZANDARYANI, SOHEILA KASHANIAN, MOHSEN SHAHLAEI & SAJAD MORADI

  3. Department of Medical Biotechnology, School of Medicine, College of Medicine and Public Health, Flinders University, Bedford Park, SA, 5042, Australia

    YADOLLAH BAHRAMI

  4. Department of Pharmacognosy and Pharmaceutical Biotechnology, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, 6714415153, Iran

    YADOLLAH BAHRAMI

  5. Molecular Biology Research Centre, Kermanshah University of Medical Sciences, Kermanshah, 6714415185, Iran

    YADOLLAH BAHRAMI

  6. Department of Pharmaceutics, Faculty of Pharmacy, Hamedan University of Medical Sciences, Hamedan, 6517838678, Iran

    KATAYOUN DERAKHSHANDEH

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  1. ABBAS HEMATI AZANDARYANI
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Correspondence to SOHEILA KASHANIAN.

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HEMATI AZANDARYANI, A., KASHANIAN, S., BAHRAMI, Y. et al. Stealth cross-linked polymeric nanoparticles for passive drug targeting: a combination of molecular docking and comprehensive in vitro assay. Bull Mater Sci 43, 232 (2020). https://doi.org/10.1007/s12034-020-02166-8

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  • DOI: https://doi.org/10.1007/s12034-020-02166-8

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