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Fabrication of chitosan microparticles loaded in chitosan and poly(vinyl alcohol) scaffolds for tissue engineering application

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Abstract

In recent decades, the use of microparticle-mediated drug delivery is widely applied in the field of biomedical application. Here, we report the new dressing material with ciprofloxacin-loaded chitosan microparticle (CMP) impregnated in chitosan (CH) and poly(vinyl alcohol) (PVA) scaffold for effective delivery of drug in a sustained manner to the wound site. Moreover, the peculiar physiochemical and structural properties of the CH–CMP scaffold has proved better tensile strength and excellent swelling to achieve 82% of drug release. In vitro biocompatibility was done for both scaffold using NIH 3T3 fibroblasts and human keratinocytes (HaCaT) cell lines. In vitro fluorescent activity showed distinct biocompatibility with good cell adhesion and proliferation. However, the CH–CMP scaffold showed best result to act as promising biomaterial in effective drug delivery in tissue engineering.

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Acknowledgements

We acknowledge CSIR-CLRI for providing the funds and infrastructure to carry out this study. Financial support from CSIR under Translational Project OLP-09/TRP is acknowledged. We sincerely thank the Director, Centre for Nanoscience and Technology, Anna University, for helping us in availing the SEM facility.

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Authors and Affiliations

  1. Bioproducts Lab, CSIR-Central Leather Research Institute, Chennai, 600020, India

    B R Srinivas Murthy, Giriprasath Ramanathan & Uma Tirichurapalli Sivagnanam

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  1. B R Srinivas Murthy
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  2. Giriprasath Ramanathan
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  3. Uma Tirichurapalli Sivagnanam
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Correspondence to Uma Tirichurapalli Sivagnanam.

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Murthy, B.R.S., Ramanathan, G. & Sivagnanam, U.T. Fabrication of chitosan microparticles loaded in chitosan and poly(vinyl alcohol) scaffolds for tissue engineering application. Bull Mater Sci 40, 645–653 (2017). https://doi.org/10.1007/s12034-017-1428-7

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